CFAR, the Core Facility for Aged Rodents, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR will continue to serve the needs of Pepper Center investigators through four Specific Aims. (1) CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease. (2) CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock;(b) calorically restricted UM-HET3 mice;and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pitl dw mutation. Mice from these colonies will be provided to faculty members working on PESC and RCDC research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds. (3) CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new fourway cross suitable for studies of late-life hearing loss, and a CAG-repeat knock-in mouse to study the timing of age-dependent motor neuron disease. (4) To nurture new rodent-based research initiatives through Core Development Projects. In the first year two such projects will be supported, one to develop instrumentation for assessment of age-dependent changes in balance and vestibular function, and the other to use calorically restricted and dwarf mice to evaluate the role of aging and anti-aging interventions in skin cell proliferation and pro-neoplastic transformation. The CFAR director will also play a role in helping to develop and design RCDC and PESC projects that make use of rodent models.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Li, Weiquan; Miller, Richard A (2015) Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J Gerontol A Biol Sci Med Sci 70:263-72
Min, Lillian; Mazzurco, Lauren; Gure, Tanya R et al. (2015) Longitudinal functional recovery after geriatric cardiac surgery. J Surg Res 194:25-33
Park, Hwan-Woo; Park, Haeli; Ro, Seung-Hyun et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5:4233
Min, Lillian; Reuben, David; Karlamangla, Arun et al. (2014) Abbreviated care-process quality indicator sets linked with survival and functional status benefit in older adults under ambulatory care. J Am Geriatr Soc 62:1442-50
Ro, Seung-Hyun; Nam, Myeongjin; Jang, Insook et al. (2014) Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A 111:7849-54
Mody, Lona; Juthani-Mehta, Manisha (2014) Urinary tract infections in older women: a clinical review. JAMA 311:844-54
Nicklett, Emily J; Taylor, Robert Joseph (2014) Racial/Ethnic predictors of falls among older adults: the health and retirement study. J Aging Health 26:1060-75
Rao, Krishna (2014) Measuring the impact of Clostridium difficile Infection with the NAP1 strain on severity and mortality. Clin Infect Dis 59:1193-4
Rao, Krishna; Young, Vincent B; Aronoff, David M (2014) Fecal microbiota therapy: ready for prime time? Infect Control Hosp Epidemiol 35:28-30
Tillou, Areti; Kelley-Quon, Lorraine; Burruss, Sigrid et al. (2014) Long-term postinjury functional recovery: outcomes of geriatric consultation. JAMA Surg 149:83-9

Showing the most recent 10 out of 137 publications