The specific aims of the UTMB Claude Pepper Older Americans Independence Center (OAIC) are to: 1) provide core support to funded translational research by UTMB investigators on muscle function and functional recovery in older adults;2) Stimulate the growth of additional interdisciplinary translational research projects to improve muscle function and functional recovery in older adults by: a) funding pilot project research to generate preliminary data in promising new areas of investigation and b) funding developmental projects to develop innovative technologies;3) Train future leaders in research in the mechanisms, prevention and treatment of muscle dysfunction and disability in older adults;4) Recruit established investigators with expertise relevant to muscle function and functional recovery in older adults into interdisciplinary translational research related to the OAIC focusi and 5) Foster collaborations between UTMB investigators and investigators at other OAIC and other institutions on studies of muscle function and functional recovery in older adults. The theme for the next cycle of our OAIC is: Translating Biological Mechanisms of Muscle Growth and Loss to Improve Function and Recovery in Older Adults. Our focus is on translating basic discoveries on the mechanisms of muscle loss and re-growth with aging to clinical practice to promote functional recovery and prevent disability in older adults. Observational sutidies will provide crucial information for selecting appropriate in-hospital, post-discharge, and long-term outcomes for inclusion in clinical trials of geriatric patient populations. Our general hypothesis is that aging induces mild but significant changes in muscle biology and function that progressively lead to muscle loss and predispose to potentially catastrophic declines in muscle mass and function during bouts of acute illness. We also hypothesize that anabolic interventions involving exercise/rehabilitation, amino acid/protein supplementation and hormonal or other pharmacological treatment can prevent the age- and disease-induced muscle loss and reduce the risk of

Public Health Relevance

We seek, during the next cycle, to 1) identify predictors of physical function and recovery from illness in hospitalized geriatric patients;2) identify potential treatments to improve function and accelerate recovery;3) determine the efficacy of the identified treatments in clinical trials in geriatric patients;and 4) increase the number of junior and senior investigators involved in geriatric research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024832-10
Application #
8696970
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (A1))
Program Officer
Eldadah, Basil A
Project Start
2005-06-15
Project End
2015-04-30
Budget Start
2014-08-01
Budget End
2015-04-30
Support Year
10
Fiscal Year
2014
Total Cost
$1,056,639
Indirect Cost
$366,025
Name
University of Texas Medical Br Galveston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Fry, Christopher S; Johnson, Darren L; Ireland, Mary Lloyd et al. (2017) ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle. J Orthop Res 35:1876-1885
Goodwin, James S; Salameh, Habeeb; Zhou, Jie et al. (2017) Association of Hospitalist Years of Experience With Mortality in the Hospitalized Medicare Population. JAMA Intern Med :
Chao, Tony; Porter, Craig; Herndon, David N et al. (2017) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc :
Krishnan, Shilpa; Pappadis, Monique R; Weller, Susan C et al. (2017) Needs of Stroke Survivors as Perceived by Their Caregivers: A Scoping Review. Am J Phys Med Rehabil 96:487-505
Nam, Sanggon; Snih, Soham Al; Markides, Kyriakos (2017) The Effects of Chronic Medical Conditions and Obesity on Self-Reported Disability in Older Mexican Americans. Tex Public Health J 69:12-15
Graber, Ted G; Borack, Michael S; Reidy, Paul T et al. (2017) Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle. Nutr Metab (Lond) 14:35
Reidy, Paul T; Fry, Christopher S; Igbinigie, Sherry et al. (2017) Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training. Med Sci Sports Exerc 49:1197-1208
Li, Shuang; Middleton, Addie; Ottenbacher, Kenneth J et al. (2017) Trajectories Over the First Year of Long-Term Care Nursing Home Residence. J Am Med Dir Assoc :
Teppala, Srinivas; Ottenbacher, Kenneth J; Eschbach, Karl et al. (2017) Variation in Functional Status After Hip Fracture: Facility and Regional Influence on Mobility and Self-Care. J Gerontol A Biol Sci Med Sci 72:1376-1382
Swartz, Maria C; Lewis, Zakkoyya H; Lyons, Elizabeth J et al. (2017) Effect of Home- and Community-Based Physical Activity Interventions on Physical Function Among Cancer Survivors: A Systematic Review and Meta-Analysis. Arch Phys Med Rehabil 98:1652-1665

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