The Leadership/Administrative Core (LAC) will have responsibility for the overall direction and operation of the Older Americans Independence Center. Our proposed center consists of a Research Career Development Core, a Pilot/Exploratory Studies Core, and two Research Cores, the Analysis Core and the Biological Studies Core;all under the direction ofthe Leadership/Administrative Core. Each of the cores will have an internal management and decision-making structure and will be granted considerable autonomy for internal research and financial operations. The primary coordinating unit will be the Internal Operating Committee as the central decision making body to successfully lead the new Center. This approach will have maximal impact on fostering geriatrics research and training in a dynamic, multidisciplinary environment. The LAC will provide the leadership necessary to harness and direct the creative energy of this complex research activity. The Core will have input from, and interaction with, key members of other units of the Medical Center, the University, and the Durham VA and will rely on two panels. Independent Review Panel and External Advisory Committee for expertise and direction in selection of future projects, pilots and junior faculty awardees. The specific goals ofthe LAC are: (1) To assure overall coordination, integration, and administration of the Duke Pepper OAIC;(2) To assure integration with other affiliated programs, e.g.. Center for the Study of Aging, the Hartford Center of Excellence, Durham VA Geriatric Research, Education and Clinical Center, Duke Translational Medicine Institute, Alzheimer's Disease Research Center, Aging Center T-32 Post-Doctoral Training program, and others.;(3) To assure efficient and appropriate use of core facilities by investigators and programs;(4) To plan and develop funding strategies for cores and support of projects;and (5) To plan and coordinate future core activities and integrate Duke Pepper OAIC activities with new programs established at Duke Medical Center.
The collective body of scientific advances in the field of aging will have considerable public impact by: (1) enhancing our understanding of multiple pathways to functional decline, (2) examining potential interventions that have potential to reverse or ameliorate functional decline, and (3) training promising new investigators who will continue to pursue clinical, basic and translational advances in the study of aging.
|Anderson, Kristin A; Madsen, Andreas S; Olsen, Christian A et al. (2017) Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio. Biochim Biophys Acta 1858:991-998|
|Hatcher, Courtney C; Collins, Amber T; Kim, Sophia Y et al. (2017) Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage. J Biomech 55:18-26|
|Schaefer, Jonathan D; Scult, Matthew A; Caspi, Avshalom et al. (2017) Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Dev Psychopathol :1-15|
|Gray, Shelly L; Hart, Laura A; Perera, Subashan et al. (2017) Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults. J Am Geriatr Soc :|
|Hall, Rasheeda K (2017) Reply to: Comment on: ""Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care"". J Am Geriatr Soc 65:880|
|AbouAssi, Hiba; Connelly, Margery A; Bateman, Lori A et al. (2017) Does a lack of physical activity explain the rheumatoid arthritis lipid profile? Lipids Health Dis 16:39|
|Hsueh, M-F; Kraus, V B; Önnerfjord, P (2017) Cartilage matrix remodelling differs by disease state and joint type. Eur Cell Mater 34:70-82|
|Colón-Emeric, Cathleen S; Corazzini, Kirsten; McConnell, Eleanor et al. (2017) Study of Individualization and Bias in Nursing Home Fall Prevention Practices. J Am Geriatr Soc 65:815-821|
|Belsky, Daniel W; Caspi, Avshalom; Cohen, Harvey J et al. (2017) Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell 16:644-651|
|Yin, Z; Fei, Z; Qiu, C et al. (2017) Dietary Diversity and Cognitive Function among Elderly People: A Population-Based Study. J Nutr Health Aging 21:1089-1094|
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