The Duke Older Americans Independence Center (OAIC) is structured to (1) enhance and support research and (2) research career development In aging research through its Core resources. The central theme of our OAIC is to understand and modify the multiple pathways of functional decline. The OAIC is based in the Duke Center for the Study of Aging and Human Development, an all-university program with strong multidisciplinary affiliated programs such as the Durham VA GRECC, the Hartford Center of Excellence, the Duke Institute for Genomic Sciences and Policy, the Duke Translational Medicine Institute, the Duke Center for Living, and the Stedman Nutrition and Metabolism Center. This rich milieu includes 130 faculty as Senior Fellows of the Aging Center and over 25 million dollars of research germane to the goals of the OAIC. The Duke OAIC will support three resource cores which have evolved from prior OAIC support: (1) an Analysis Core, (2) a Biochemical Pathways Core, and a (3) Metabolomics Core. Several externally funded NIH, VA or industry-sponsored grants, with relevant study aims and study populations will receive support from these cores.
New specific aims relevant to our Center theme will be added for each external project. Data from these studies (interventional and cohort) will be added to a common database that includes data from our prior funding periods. This extends our research capabilities and allows us to develop new ideas for investigation. The Research Career Development Core and the Pilot/Exploratory Studies Core will facilitate career development and enhancement of research capabilities with established post-doctoral Research and Geriatric Training Programs and participation in the Duke OAIC Research Seminar Series, the Data Integration Working Group, the Pilot Studies workshop, the Pepper Scholars program, and access as needed to a Functional Measurement Resource group. The cores are seamlessly integrated and work closely to develop young trainees and research projects by interactions from concept through completion of proposed work. During the first year, three pilot projects, two development projects, and three junior faculty will be supported. Subsequent support for career development, pilot projects, and development will be selected on a competitive basis using criteria clearly defined in the OAIC guidelines. A Leadership and Administrative Core will direct and coordinate OAIC activities to ensure continued integration of center activities.
The public impact will be a significant advancement in the basic understanding of the multiple factors that contribute to functional decline, and the enhancement of interventions directed at improving the overall quality of life of older adults.
|Lee, Richard H; Pearson, Megan; Lyles, Kenneth W et al. (2016) Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture. Rural Remote Health 16:3440|
|Cher, Wei Liang; Utturkar, Gangadhar M; Spritzer, Charles E et al. (2016) An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity. J Biomech 49:3026-3030|
|Schaefer, Jonathan D; Caspi, Avshalom; Belsky, Daniel W et al. (2016) Enduring Mental Health: Prevalence and Prediction. J Abnorm Psychol :|
|Belsky, Daniel W; Moffitt, Terrie E; Corcoran, David L et al. (2016) The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. Psychol Sci 27:957-72|
|Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243|
|Bartlett, David B; Connelly, Margery A; AbouAssi, Hiba et al. (2016) A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. Arthritis Res Ther 18:86|
|Hsueh, Ming-Feng; Khabut, Areej; KjellstrÃ¶m, Sven et al. (2016) Elucidating the Molecular Composition of Cartilage by Proteomics. J Proteome Res 15:374-88|
|Dungan, Jennifer R; Qin, Xuejun; Horne, Benjamin D et al. (2016) Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS One 11:e0154856|
|Whitson, Heather E; Duan-Porter, Wei; Schmader, Kenneth E et al. (2016) Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. J Gerontol A Biol Sci Med Sci 71:489-95|
|Porter Starr, Kathryn N; Pieper, Carl F; Orenduff, Melissa C et al. (2016) Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1369-75|
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