RCS The Metabolomics Core (RCS) has developed a diverse set of complementary metabolomics technologies that provide a rare combination of broad coverage and analytical precision, and deploys these tools in scientific and clinical collaborations that focus on metabolic signatures associated with functional decline in aging. The Duke Stedman Center's metabolomics core has been an integral component ofthe Duke's Pepper Older Americans Independence Center (OAIC) for the past 7 years and is now enhanced as an independent core. The metabolomics core is well known for its work in applying targeted mass-spectrometry (MS)-based metabolic profiling for understanding of disease and biological mechanisms. The Core will provide this analytic expertise to Pepper projects. Supported projects include: Pilot Projects (one in Year 1), Pepper Research Career Development awardees (two in Years 1-3), External Projects (five in Years 1-5), and future pilot and career development projects as they are selected and initiated. Ofthe external projects, one will characterize metabolomics biomarkers related to successful aging through the lifespan, and three interventional projects will critically address the modifiability of pertinent metabolites with treatments aimed at improving function (weight loss, protein supplements, exercise). Importantly, the lab has also developed and applied non-targeted gas chromatography (GC)/MS methods to obtain broader surveys of metabolic changes in biological systems. Use of non-targeted GC/MS allows measurement of analytes that are not included in the targeted modules, and thereby represents a tool for discovery and hypothesis formulation. Through activities of RC3, we propose to expand the scope ofthe targeted methods and have proposed two development projects that have evolved from our research in aging, thereby providing more powerful tools to support our work. It is also important to note that the RC3 team has recently engaged with other Pepper Centers, thereby forming important collaborative connections between the Duke Pepper OAIC and those groups. Success of RC3 will be highly innovative, because it will provide """"""""one-stop shopping"""""""" access to comprehensive targeted (quantitative) and non-targeted (discovery) metabolomics tools via a single portal. Importantly, faculty and staff associated with this core are highly experienced in metabolic research, and will assist Duke's Pepper OAIC faculty and fellows with study design and interpretation, thus ensuring a maximally productive interaction of users with this core.

Public Health Relevance

The Metabolomics Core provides analytic tools to help elucidate metabolic signatures underlying age-related functional decline. In common with the Biochemical Pathways Core (RC2), the goal is to identify and validate biomarkers that predict risk for functional decline and to monitor the efficacy of interventions targeted toward improving physical function, metabolic health, and longevity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG028716-08
Application #
8673966
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$84,813
Indirect Cost
$30,792
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lee, Richard H; Pearson, Megan; Lyles, Kenneth W et al. (2016) Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture. Rural Remote Health 16:3440
Cher, Wei Liang; Utturkar, Gangadhar M; Spritzer, Charles E et al. (2016) An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity. J Biomech 49:3026-3030
Schaefer, Jonathan D; Caspi, Avshalom; Belsky, Daniel W et al. (2016) Enduring Mental Health: Prevalence and Prediction. J Abnorm Psychol :
Belsky, Daniel W; Moffitt, Terrie E; Corcoran, David L et al. (2016) The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. Psychol Sci 27:957-72
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243
Bartlett, David B; Connelly, Margery A; AbouAssi, Hiba et al. (2016) A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. Arthritis Res Ther 18:86
Hsueh, Ming-Feng; Khabut, Areej; Kjellström, Sven et al. (2016) Elucidating the Molecular Composition of Cartilage by Proteomics. J Proteome Res 15:374-88
Dungan, Jennifer R; Qin, Xuejun; Horne, Benjamin D et al. (2016) Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS One 11:e0154856
Whitson, Heather E; Duan-Porter, Wei; Schmader, Kenneth E et al. (2016) Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. J Gerontol A Biol Sci Med Sci 71:489-95
Porter Starr, Kathryn N; Pieper, Carl F; Orenduff, Melissa C et al. (2016) Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1369-75

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