LAC The Leadership and Administrative Core (LAC) will have responsibility for the overall direction and operation of the Older Americans Independence Center. Our proposed center consists of a Research Career Development Core, a Pilot/Exploratory Studies Core, and three Resource Cores;the Analysis Core, the Biochemical Pathways Core and the Metabolomics Core, all under the direction ofthe Leadership and Administrative Core. Each ofthe cores will have an internal management and decision-making structure while at the same time being highly integrated functionally with the other cores. The primary coordinating unit will be the Internal Operating Committee as the central decision making body to successfully lead the new Center. This approach will have maximal impact on fostering geriatrics research and training in a dynamic, multidisciplinary environment. The LAC will provide the leadership necessary to harness and direct the creative energy of this complex research activity. The LAC administratively supports a Research Seminar Series, a Data Integration Working Group and a Functional Measurement Resource Panel. The Core will have input from, and interaction with, key members of other units of the Medical Center, the University, and the Durham VA and will rely on two panels, Independent Review Panel and External Advisory Board for expertise and direction in selection of future projects, pilots and junior faculty awardees. The specific goals ofthe LAC are: (1) To assure overall coordination, integration, and administration ofthe Duke Pepper OAIC including oversight of data safety and monitoring of studies;(2) To assure integration with other affiliated programs, e.g.. Center for the Study of Aging, the Hartford Center of Excellence, Durham VA Geriatric Research, Education and Clinical Center, Duke Translational Medicine Institute, Alzheimer's Disease Research Center, Aging Center T-32 Post-Doctoral Training program, and others.;(3) To assure efficient and appropriate use of core facilities by investigators and programs;(4) To plan and develop funding strategies for cores and support of projects;and (5) To plan and coordinate future core activities and integrate Duke Pepper OAIC activities with new programs established at Duke Medical Center.

Public Health Relevance

;The collective body of scientific advances in the field of aging will have considerable public impact by: (1) enhancing our understanding of multiple pathways to functional decline, (2) examining potential interventions that have potential to reverse or ameliorate functional decline, and (3) training promising new investigators who will continue to pursue clinical, basic and translational advances in the study of aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028716-09
Application #
8695264
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
$100,230
Indirect Cost
$36,389
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lee, Richard H; Pearson, Megan; Lyles, Kenneth W et al. (2016) Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture. Rural Remote Health 16:3440
Cher, Wei Liang; Utturkar, Gangadhar M; Spritzer, Charles E et al. (2016) An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity. J Biomech 49:3026-3030
Schaefer, Jonathan D; Caspi, Avshalom; Belsky, Daniel W et al. (2016) Enduring Mental Health: Prevalence and Prediction. J Abnorm Psychol :
Belsky, Daniel W; Moffitt, Terrie E; Corcoran, David L et al. (2016) The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. Psychol Sci 27:957-72
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243
Bartlett, David B; Connelly, Margery A; AbouAssi, Hiba et al. (2016) A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. Arthritis Res Ther 18:86
Hsueh, Ming-Feng; Khabut, Areej; Kjellström, Sven et al. (2016) Elucidating the Molecular Composition of Cartilage by Proteomics. J Proteome Res 15:374-88
Dungan, Jennifer R; Qin, Xuejun; Horne, Benjamin D et al. (2016) Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS One 11:e0154856
Whitson, Heather E; Duan-Porter, Wei; Schmader, Kenneth E et al. (2016) Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. J Gerontol A Biol Sci Med Sci 71:489-95
Porter Starr, Kathryn N; Pieper, Carl F; Orenduff, Melissa C et al. (2016) Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1369-75

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