The principal goal of the Pilot/Exploratory Studies Core (PESC) is to foster high-quality, innovative, investigator-initiated research """"""""Translational Research on Cardiac and Skeletal Muscle Dysfunction in Aging and Disease"""""""". Such studies may be designed to prevent and/or treat morbidity and mortality associated with cardiac and skeletal muscle weakness and its sequelae. This will be achieved by funding pilot and exploratory studies that have the highest potential In terms of generating data, resulting in influential publications, and culminating in extramural funding. Such studies are thus deemed likely to advance the careers of promising scientists entering this field. Activities of the PESC will contribute to the overall goals of the Arkansas Older Americans Independence Center (OAiC) by strengthening research programs that focus on aging cardiac and skeletal muscle weakness and nutrition as one of the key interventions. By offering pilot grant support and strong mentoring opportunities, the PESC will provide a valuable mechanism for junior investigators to overcome the initial hurdles to securing research funds and to help propel their careers in research intended to improve outcomes for older adults. It will also help us to attract senior investigators from other disciplines to the intersection of research on striated muscle (both cardiac and skeletal) and nutrient supplementation. We are fortunate to have received ten excellent proposals, both from senior, internationally recognized scientists, who are poised to enter this area of investigation, and from exceptional young investigators starting on their career goals. Martin Hauer-Jensen, MD, PhD, an outstanding clinical researcher at the University of Arkansas for Medical Sciences (UAMS), exemplifies the first category;he has proposed to study the physiological basis for restoration of skeletal muscle mass and strength following arginine supplementation in human subjects. Two junior-faculty researchers were also selected: Anna Csiszar, MD, PhD, of the University of Oklahoma, will investigate the effects of arginine supplementation on cardiac and skeletal muscle function in rodents, and Sharda Singh, PhD (UAMS), proposes to study the metabolic changes underlying sarcopenia and ectopic fat accumulation in skeletal and cardiac muscle of aging mice. These three proposals were selected by the Internal Review and Executive Committee members from UAMS and OUHSC. This proposal review committee was guided by the same selection criteria presented in this proposal: high quality of proposed science, translational potential, congruence with the goals of the Arkansas OAIC, likelihood that PESC support will lead to extramural funding, and full utilization of cores RC1, RC2 and RC3.

Public Health Relevance

The PESC will contribute to the overall goals of the Arkansas OAIC, by strengthening programs that focus on translational research in geriatrics and muscle maintenance or repair. By offering pilot grant support and strong mentoring opportunities, the PESC will provide a valuable mechanism for junior investigators to overcome the initial hurdles to securing research funds and help propel their careers in translational research on cardiac and skeletal muscle dysfunction In aging and disease. It will also help us attract senior Investigators and further accelerate the pace of research in these areas.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
1P30AG028718-01A2
Application #
8206061
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$239,169
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Ashpole, Nicole M; Logan, Sreemathi; Yabluchanskiy, Andriy et al. (2017) IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience 39:129-145
Tarantini, Stefano; Tran, Cam Ha T; Gordon, Grant R et al. (2017) Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Exp Gerontol 94:52-58
Pereira, Sónia G; Moura, João; Carvalho, Eugénia et al. (2017) Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies. Front Microbiol 8:1791
George, Masil; Azhar, Gohar; Pangle, Amanda et al. (2017) Feasibility of Conducting a 6-month long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure. J Physiother Phys Rehabil 2:
Hamarsland, Håvard; Nordengen, Anne Lene; Nyvik Aas, Sigve et al. (2017) Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. J Int Soc Sports Nutr 14:43
Moura, João; Rodrigues, João; Gonçalves, Marta et al. (2017) Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol 14:758-769
Burgeiro, Ana; Cerqueira, Manuela G; Varela-Rodríguez, Bárbara M et al. (2017) Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients 9:
Kim, Il-Young; Schutzler, Scott E; Azhar, Gohar et al. (2017) Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial. BMC Nutr 3:
Zhang, Xiaomin; Azhar, Gohar; Wei, Jeanne Y (2017) SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. PLoS One 12:e0190011
Podlutsky, Andrej; Valcarcel-Ares, Marta Noa; Yancey, Krysta et al. (2017) The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer. Geroscience 39:147-160

Showing the most recent 10 out of 73 publications