Our mission for the Research Career Development Core (RCDC) of the Arkansas OIAC is to develop junior investigators to become the next generation of leaders in geriatric/gerontologic research.
We aim to accomplish this mission by creating a training program for clinician scientists and talented young investigators who are interested in efforts to better understand cardiac and skeletal muscle dysfunction in aging and disease. This training program will provide selected trainees with partial salary support, travel, individually tailored course work, grant-writing instruction, career mentoring and consultation, didactic training, networking with established investigators, and regular evaluation of their research learning experience. The trainees will have access to infrastructural support?laboratories, office space, computers, interview and/or clinical research rooms, administrative support, statistical assistance, and grant writers?all available at the Donald W. Reynolds Institute on Aging (lOA) and elsewhere on the UAMS campus. Our goal is to offer a well integrated training and mentoring program within a research-intensive environment that nurtures and promotes talented junior faculty as they acquire and refine the skills that are necessary to assume research independence and future academic leadership, i.e., research study design, proposal development and execution, writing for scientific publications, professionalism and leadership training, and the to translate their research findings into effective and successful future interventions.
Specific aims of the RCDC are as follows:
Specific Aim 1. Recruit postdoctoral fellows, junior faculty, and/or midlevel investigators who are interested in aging research within the center theme, to become independent investigators and our future academic leaders in geriatrics and gerontology.
Specific Aim 2. Provide programmatic support to allow each trainee to develop research expertise and continue training and education in aging research.
Specific Aim 3. Provide mentoring to foster career development with regular evaluation of progress.
Specific Aim 4. Provide for each trainee the advice and guidance needed to tailor individual-specific educational and research experiences that are most appropriate for each person's background.
Specific Aim 5. Provide access to the complete array of equipment and facilities available in the lOA, the Arkansas OAIC, and other research facilities throughout our campus, including the NIH-funded CCTR.
impact of this project is to discover new ways to improve and prevent the typical agerelated progressive loss of strength and reserve of the heart and skeletal muscle in the elderiy, changes which are associated with significant morbidity and mortality as well as an enormous economic burden for the nation.
|Zhang, Xiaomin; Williams, Emmanuel D; Azhar, Gohar et al. (2016) Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? Exp Gerontol 82:150-9|
|Alagpulinsa, David A; Ayyadevara, Srinivas; Yaccoby, Shmuel et al. (2016) A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther 15:241-50|
|Kim, Il-Young; Schutzler, Scott; Schrader, Amy et al. (2016) The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. Am J Physiol Endocrinol Metab 310:E73-80|
|Carvalho, Eugenia; Lopaschuk, Gary D; BÃ¸rsheim, Elisabet et al. (2016) Reply to Katlandur, Ozbek, and Keser. Am J Physiol Endocrinol Metab 310:E863|
|Baum, Jamie I; Kim, Il-Young; Wolfe, Robert R (2016) Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients 8:|
|Deak, Ferenc; Freeman, Willard M; Ungvari, Zoltan et al. (2016) Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment. J Gerontol A Biol Sci Med Sci 71:13-20|
|Tarantini, Stefano; Giles, Cory B; Wren, Jonathan D et al. (2016) IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr) 38:239-258|
|Perry Jr, Richard A; Brown, Lemuel A; Lee, David E et al. (2016) Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. Mech Ageing Dev 157:7-16|
|Tarantini, Stefano; Tucsek, Zsuzsanna; Valcarcel-Ares, M Noa et al. (2016) Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr) 38:273-289|
|Penthala, Narsimha Reddy; Yadlapalli, Jaishankar K B; Parkin, Sean et al. (2016) Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallogr E Crystallogr Commun 72:652-5|
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