The theme of the Arkansas OAIC at UAMS is """"""""Translational research on cardiac and skeletal muscle dysfunction in aging and disease."""""""" The main goals of the Arkansas OAIC are 1) To promote research that will both provide a mechanistic understanding of the basis for declining skeletal muscle function and myocardial performance with advancing age and translate what is learned from those studies to intervention studies that will ultimately affect nutritional recommendations and standard of care in the elderly; 2) To introduce state-of-the-art methodologies for studying protein metabolism to better enable basic molecular-based studies to ultimately translate the findings to the performance of clinical trials aimed at improving outcomes in elderly individuals; 3) use novel nutritional interventions in the prevention and treatment of cardiac and skeletal muscle weakness; 4) To train a new generation of geriatricians and gerontologists in improving functional independence of older Americans through therapeutic nutritional interventions. These goals will be achieved via the following Specific Aims.
Specific Aim 1. Provide scientific, intellectual, and innovation leadership among UAMS investigators.
Specific Aim 2. Stimulate translation between basic and clinical research through collaboration and interaction among investigators to improve our understanding of mechanisms contributing to declining skeletal muscle function and myocardial performance with age. Interventions will include, but not be limited to, therapeutic nutrient supplementation.
Specific Aim 3. Stimulate incorporation of emerging technologies and novel methods and approaches in analyzing protein metabolism and nutritional interventions for cardiac and skeletal muscle weakness.
Specific Aim 4. Serve as a source of advice and collaboration to other institutions (especially OUHSC and other OAICs) regarding technology and expertise in the center theme of the proposal and facilitate multi- and interdisciplinary strategies.
Specific Aim 5. Provide career development for future research leaders by increasing the recruitment of young and established investigators In aging, while emphasizing recruitment of minorities to UAMS.
Specific Aim 6. Expand the research outreach to maximally include minority representation in all studies. This OAIC would help translate innovative muscle research to improve care, including for the rural elderly.

Public Health Relevance

This research will broaden our understanding of weakness of the cardiac and skeletal muscles that occurs as a result of aging or age-related diseases. We will also design methods to prevent and treat this weakness with nutrient supplementation, therapeutic nutrition and/or other interventions and improve the cardiac and skeletal muscle health of seniors. This OAIC will be instrumental in training the next generation of researchers in translational aging research to improve the functional independence of older Americans.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
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University of Arkansas for Medical Sciences
Other Clinical Sciences
Schools of Medicine
Little Rock
United States
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Yu, Li-Rong; Cao, Zhijun; Makhoul, Issam et al. (2018) Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Exp Biol Med (Maywood) 243:248-255
Coker, Robert H; Wolfe, Robert R (2018) Weight Loss Strategies in the Elderly: A Clinical Conundrum. Obesity (Silver Spring) 26:22-28
Fonseca, Ana Catarina R G; Carvalho, Eugénia; Eriksson, Jan W et al. (2018) Calcineurin is an important factor involved in glucose uptake in human adipocytes. Mol Cell Biochem 445:157-168
George, Masil; Azhar, Gohar; Pangle, Amanda et al. (2017) Feasibility of Conducting a 6-month long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure. J Physiother Phys Rehabil 2:
Tarantini, Stefano; Tran, Cam Ha T; Gordon, Grant R et al. (2017) Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Exp Gerontol 94:52-58
Hamarsland, Håvard; Nordengen, Anne Lene; Nyvik Aas, Sigve et al. (2017) Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. J Int Soc Sports Nutr 14:43
Moura, João; Rodrigues, João; Gonçalves, Marta et al. (2017) Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol 14:758-769
Burgeiro, Ana; Cerqueira, Manuela G; Varela-Rodríguez, Bárbara M et al. (2017) Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients 9:
Tarantini, Stefano; Valcarcel-Ares, Noa M; Yabluchanskiy, Andriy et al. (2017) Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell 16:469-479
Zhang, Xiaomin; Azhar, Gohar; Wei, Jeanne Y (2017) SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. PLoS One 12:e0190011

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