The overall goal of the proposed Arkansas Older Americans Independence Center (OAIC) is to promote the translation of basic and physiological research on cardiac and skeletal muscle dysfunction in aging and disease to clinically relevant outcomes that ultimately have a positive influence on the standard of care. A particular emphasis will be nutritional approaches to ameliorating the physiological impact of changes in muscle metabolism. The fundamental strategy centers on determining the metabolic basis for observed catabolic responses in order to design and test approaches to counteract these responses. Stable isotope tracer methodology is uniquely suited to advance this overall goal of the Arkansas OAIC. Stable isotope tracer methodology can be used in the most basic in vitro studies and in small animal studies to quantify metabolic reactions, and the same methodology can be extended to human studies. A number of clinical outcome studies have validated the success of acute tracer studies of muscle metabolism in predicting longterm outcomes (e.g., references. 1,2). Consequently, the Analytical Core's primary goal will be to support the performance of stable isotope tracer experiments, including sample and data analysis, and to continue to develop new methodologies, as needed, to support studies related to therapeutic nutrition and aging, with particular emphasis on issues related to skeletal and cardiac muscle dysfunction associated with aging and/or congestive heart failure (CHF), including the condition of cardiac cachexia. We will also actively train investigators on stable isotope tracer methodology.

Public Health Relevance

Quantification of metabolic rates by the use of stable isotope tracer methods can be accomplished in a matter of a few hours in human subjects. These studies enable the development of new approaches which can subsequently be tested in long-term outcome studies. Thus stable isotope tracer methodology can serve as the cornerstone in translating basic metabolic research into practical approaches of value to the general population of aging individuals.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
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University of Arkansas for Medical Sciences
Little Rock
United States
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Abraham, Rtika R; Girotra, Mohit; Wei, Jeanne Y et al. (2015) Is short-term percutaneous endoscopic gastrostomy tube placement beneficial in acutely ill cognitively intact elderly patients? A proposed decision-making algorithm. Geriatr Gerontol Int 15:572-8
Zhang, Xiaomin; Azhar, Gohar; Rogers, Steven C et al. (2014) Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice. BMC Cell Biol 15:32
Deutz, Nicolaas E; Wolfe, Robert R (2013) Is there a maximal anabolic response to protein intake with a meal? Clin Nutr 32:309-13
Zhang, Xiao-jun; Wang, Lijian; Tuvdendorj, Demidmaa et al. (2013) Acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis. Metabolism 62:44-51
Mendiratta, Priya; Wei, Jeanne Y; Gomez, Alberto et al. (2013) Cardiopulmonary resuscitation requiring extracorporeal membrane oxygenation in the elderly: a review of the Extracorporeal Life Support Organization registry. ASAIO J 59:211-5
Rogers, Steven C; Zhang, Xiaomin; Azhar, Gohar et al. (2013) Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase. J Gerontol A Biol Sci Med Sci 68:1469-81
Zhang, Xiaomin; Azhar, Gohar; Wei, Jeanne Y (2012) The expression of microRNA and microRNA clusters in the aging heart. PLoS One 7:e34688