The overall goal of the proposed Arkansas Older Americans Independence Center (OAIC) is to promote the translation of basic and physiological research on cardiac and skeletal muscle dysfunction in aging and disease to clinically relevant outcomes that ultimately have a positive influence on the standard of care. A particular emphasis will be nutritional approaches to ameliorating the physiological impact of changes in muscle metabolism. The fundamental strategy centers on determining the metabolic basis for observed catabolic responses in order to design and test approaches to counteract these responses. Stable isotope tracer methodology is uniquely suited to advance this overall goal of the Arkansas OAIC. Stable isotope tracer methodology can be used in the most basic in vitro studies and in small animal studies to quantify metabolic reactions, and the same methodology can be extended to human studies. A number of clinical outcome studies have validated the success of acute tracer studies of muscle metabolism in predicting longterm outcomes (e.g., references. 1,2). Consequently, the Analytical Core's primary goal will be to support the performance of stable isotope tracer experiments, including sample and data analysis, and to continue to develop new methodologies, as needed, to support studies related to therapeutic nutrition and aging, with particular emphasis on issues related to skeletal and cardiac muscle dysfunction associated with aging and/or congestive heart failure (CHF), including the condition of cardiac cachexia. We will also actively train investigators on stable isotope tracer methodology.

Public Health Relevance

Quantification of metabolic rates by the use of stable isotope tracer methods can be accomplished in a matter of a few hours in human subjects. These studies enable the development of new approaches which can subsequently be tested in long-term outcome studies. Thus stable isotope tracer methodology can serve as the cornerstone in translating basic metabolic research into practical approaches of value to the general population of aging individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028718-04
Application #
8726257
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Zhang, Xiaomin; Williams, Emmanuel D; Azhar, Gohar et al. (2016) Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? Exp Gerontol 82:150-9
Alagpulinsa, David A; Ayyadevara, Srinivas; Yaccoby, Shmuel et al. (2016) A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther 15:241-50
Kim, Il-Young; Schutzler, Scott; Schrader, Amy et al. (2016) The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. Am J Physiol Endocrinol Metab 310:E73-80
Carvalho, Eugenia; Lopaschuk, Gary D; Børsheim, Elisabet et al. (2016) Reply to Katlandur, Ozbek, and Keser. Am J Physiol Endocrinol Metab 310:E863
Baum, Jamie I; Kim, Il-Young; Wolfe, Robert R (2016) Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients 8:
Deak, Ferenc; Freeman, Willard M; Ungvari, Zoltan et al. (2016) Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment. J Gerontol A Biol Sci Med Sci 71:13-20
Tarantini, Stefano; Giles, Cory B; Wren, Jonathan D et al. (2016) IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr) 38:239-258
Perry Jr, Richard A; Brown, Lemuel A; Lee, David E et al. (2016) Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. Mech Ageing Dev 157:7-16
Tarantini, Stefano; Tucsek, Zsuzsanna; Valcarcel-Ares, M Noa et al. (2016) Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr) 38:273-289
Penthala, Narsimha Reddy; Yadlapalli, Jaishankar K B; Parkin, Sean et al. (2016) Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallogr E Crystallogr Commun 72:652-5

Showing the most recent 10 out of 62 publications