The Biostatistics and Data Management Core (RC3) is one of four resource cores in the OAIC at the University of Florida. The mission ofthe UF OAIC is (1) to assess the risk factors and better understand the biological mechanisms of physical disability in older adults, (2) to develop and test effective prevention therapies, and (3) to educate and train new investigators in research on aging and disability, while developing their leadership qualities. The Biostatistics and Data Management Core is a key cog in the interaction between scientists from many disciplines to accomplish this mission. The core functions as both a data analysis resource and as a data coordinating center, involved in constructing data collection forms and managing the data (including quality control) for the studies conducted within the OAIC. In this capacity, the core maintains and updates the registry for the Recruitment, Adherence, and Retention Core (RC4) and tracks all research conducted within the OAIC with a web tracking system. The core is involved in all phases of these studies including initial study design and sample size calculations pre-proposal, randomization, and state-of-the-art statistical analyses once the data are completed. For study designs and data for which currently methodology is lacking, the core has the expertise to develop new state of the art methodology to perform correct and appropriate analyses of data collected in the Center. The Biostatistics and Data Management Core also is involved in preparation of manuscripts for dissemination within the research community. Finally, the Core serves as a key resource to the Junior Scholars of the Research Career Development Core (RCDC), providing consulting services and periodic special interest training topics, such as research methods, power analysis, analysis of incomplete data, principles of data management, and analysis of longitudinal data.
The core ensures proper and efficient designs and analyses for all studies conducted to examine sarcopenia and aging. In addition, the core provides the interface to the UF&Shands research data repository which can be invaluable for recruiting, generating research hypotheses, and pilot studies. The core also provides essential training for junior investigators and Pepper Scholars on research design and statistical methods and analyses.
|Chun, Sung Kook; Go, Kristina; Yang, Ming-Jim et al. (2016) Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicol Res 32:35-46|
|Loftus, Tyler J; Brakenridge, Scott C; Moore, Frederick A et al. (2016) Routine surveillance cholangiography following percutaneous cholecystostomy delays drain removal and cholecystectomy. J Trauma Acute Care Surg :|
|(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222|
|Loftus, Tyler J; Jordan, Janeen R; Croft, Chasen A et al. (2016) Temporary abdominal closure for trauma and intra-abdominal sepsis: different patients, different outcomes. J Trauma Acute Care Surg :|
|Mankowski, Robert T; Ahmed, Shakeel; Beaver, Thomas et al. (2016) Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study. J Transl Med 14:305|
|Valiani, Vincenzo; Gao, Shiyao; Chen, Zhiguo et al. (2016) In-Hospital Mobility Variations Across Primary Diagnoses Among Older Adults. J Am Med Dir Assoc 17:465.e1-8|
|Lopez, Maria-Cecilia; Efron, Philip A; Ozrazgat-Baslanti, Tezcan et al. (2016) Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock. J Trauma Acute Care Surg 81:478-85|
|Bryant, Andrew J; Carrick, Ryan P; McConaha, Melinda E et al. (2016) Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 310:L249-62|
|Valiani, Vincenzo; Corbett, Duane B; Knaggs, Jeffrey D et al. (2016) Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue. J Gerontol A Biol Sci Med Sci 71:1444-1450|
|Flores-Toro, Joseph A; Go, Kristina L; Leeuwenburgh, Christiaan et al. (2016) Autophagy in the liver: cell's cannibalism and beyond. Arch Pharm Res 39:1050-61|
Showing the most recent 10 out of 438 publications