The mission of the University of Florida Older Americans Independence Center (OAIC) is to assess the risk factors of physical disability in older adults, develop and test effective prevention therapies, and train new investigators in research on aging and disability, while developing their leadership qualities. Our strategy is to attract studies and investigators from diverse behavioral, clinical, and basic science disciplines towards research on aging that is focused on a common research theme, and this, in turn, allows us to accomplish our mission. The theme, "sarcopenia and prevention of disability", is pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, and epidemiology. This research theme addresses the general goal of the OAIC program, namely, to increase scientific knowledge that leads to better ways to maintain or restore independence of older persons. Our research objectives are to (1) assess, using translational research (between basic and clinical disciplines) multiple factors such as biological, co-morbid, psychosocial, and behavioral that contribute to sarcopenia, physical function decline, and progression to disability and (2) develop and reliably test in clinical and pre-clinical studies interventions that target sarcopenia, in order to prevent, delay or recover the age-related declines in physical function and the progression to disability. To address these objectives the proposed OAIC includes the following integrated cores, which support investigators. Junior Scholars, infrastructure, and services: the Leadership and Administrative Core, the Research Career Development Core, the Pilot / Exploratory Studies Core, the Clinical Translational Research Core, the Metabolism and Biomarkers Core, the Biostatistics and Data Management Core, and the Recruitment, Adherence and Retention Core. We train Junior Scholars and support external studies, research development projects, and pilot/exploratory studies. A major strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects and investigators that address one common research theme to be explored through the whole spectrum of biomedical investigation.

Public Health Relevance

Better knowledge of the etiologic factors leading to disability and developing efficacious and effective interventions to avert disability will have a major impact on practicing evidence based geriatric medicine and public health.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Florida
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Sink, Kaycee M; Espeland, Mark A; Rushing, Julia et al. (2014) The LIFE Cognition Study: design and baseline characteristics. Clin Interv Aging 9:1425-36
Anton, Stephen D; Embry, Chelsea; Marsiske, Michael et al. (2014) Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study. Exp Gerontol 57:181-7
Clark, David J; Reid, Kieran F; Patten, Carolynn et al. (2014) Does quadriceps neuromuscular activation capability explain walking speed in older men and women? Exp Gerontol 55:49-53
Buford, Thomas W; Anton, Stephen D (2014) Resveratrol as a supplement to exercise training: friend or foe? J Physiol 592:551-2
Cruz-Almeida, Yenisel; Black, Mieniecia L; Christou, Evangelos A et al. (2014) Site-specific differences in the association between plantar tactile perception and mobility function in older adults. Front Aging Neurosci 6:68
Gentile, Lori F; Nacionales, Dina C; Lopez, M Cecilia et al. (2014) Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol 192:3156-65
Vaz Fragoso, Carlos A; Miller, Michael E; Fielding, Roger A et al. (2014) Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc 62:1064-72
Martin, A Daniel; Joseph, Anna-Marie; Beaver, Thomas M et al. (2014) Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Crit Care Med 42:e152-6
Anton, Stephen D (2014) Can non-nutritive sweeteners enhance outcomes of weight loss interventions? Obesity (Silver Spring) 22:1413-4
Vaz Fragoso, Carlos A; Hsu, Fang-Chi; Brinkley, Tina et al. (2014) Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. J Am Med Dir Assoc 15:665-70

Showing the most recent 10 out of 130 publications