PROJECT SUIWMARY The Clinical Translational Resource Core (RC 1) is a key resource for the University of Florida (UF) Older Americans Independence Center (OAIC), providing the infrastructure and expertise for conduding clinical and pre-clinical research across the spedrum of translational investigation. Its primary goal is to encourage and facilitate clinical translational research focused on sarcopenia and disability prevention. The RCI has four Specific Aims: ? Aim 1: To promote and facilitate translation from pre-clinical research and pilot studies into clinical trials in older persons. ? Aim 2: To promote and facilitate the development of pharmacologic, nutritional and behavioral interventions to prevent sarcopenia, and improve physical function and quality of life of older adults. ? Aim 3: To utilize existing data sets and stored biological specimens for secondary analyses to inform and support future clinical trials. ? Aim 4: To provide the research infrastructure, resources, and intellectual environment to facilitate translational research related to sarcopenia and disability prevention. The RCI provides infrastructure and personnel (including UOl and R01 funded investigators) to support the development and implementation of pre-clinical research, pharmacologic, nutritional and behavioral interventions, and observational studies addressing factors contributing to sarcopenia and implications for functional decline and disability. Integrated with the UF Clinical Translational Science Institute (CTSI) as its Aging Clinical Research Unit (Aging CRU) and building on close collaborations with other OAIC cores, the RCI will support pilot/exploratory projects, developmental projects, and external projects. The Core will also provide senior level Investigators with established track records as mentors for career development to lead each of these goals, providing expertise and promoting a rich environment for junior faculty research and senior faculty collaboration.
Age-related decline in physical function and related costs of health care and services pose a major challenge for an aging society. While public health principles encourage evidence -based preventive activities for acute and chronic disease, to date there is no conclusive evidence supporting the efficacy of an intervention to prevent or reverse physical disability in older persons. Research conducted through the UF OAIC seeks to address this gap through its focus on sarcopenia and disability prevention: to improve our understanding of age-related changes in muscle structure and function, explore their impact on fundional impairment and physical disability, as well as develop and test interventions targeting sarcopenia to prevent or reverse impairment, disability, and loss of independence in older populations. The Clinical Translational Resource Core (RCI) builds on pre-clinical, clinical, and epidemiologic research findings to develop and test interventions in pilot/exploratory projects and Phase 2 and 3 clinical trials and takes advantage of ongoing clinical studies to promote translation into basic/mechanistic studies.
|Brakenridge, Scott C; Efron, Philip A; Stortz, Julie A et al. (2018) The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients. J Trauma Acute Care Surg 85:247-255|
|Shenkman, Elizabeth; Hurt, Myra; Hogan, William et al. (2018) OneFlorida Clinical Research Consortium: Linking a Clinical and Translational Science Institute With a Community-Based Distributive Medical Education Model. Acad Med 93:451-455|
|Hernandez, Abbi R; Hernandez, Caesar M; Campos, Keila et al. (2018) A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus. Front Aging Neurosci 10:391|
|Liu, Xinyue; Carney, Paul R; Bussing, Regina et al. (2018) Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy. J Child Adolesc Psychopharmacol 28:111-116|
|Dahodwala, Nabila; Shah, Krunal; He, Ying et al. (2018) Sex disparities in access to caregiving in Parkinson disease. Neurology 90:e48-e54|
|Buford, Thomas W; Manini, Todd M; Kairalla, John A et al. (2018) Mitochondrial DNA Sequence Variants Associated With Blood Pressure Among 2 Cohorts of Older Adults. J Am Heart Assoc 7:e010009|
|Rillamas-Sun, Eileen; LaMonte, Michael J; Evenson, Kelly R et al. (2018) The Influence of Physical Activity and Sedentary Behavior on Living to Age 85 Years Without Disease and Disability in Older Women. J Gerontol A Biol Sci Med Sci 73:1525-1531|
|Chen, Haiying; Rejeski, W Jack; Gill, Thomas M et al. (2018) A Comparison of Self-report Indices of Major Mobility Disability to Failure on the 400-m Walk Test: The LIFE Study. J Gerontol A Biol Sci Med Sci 73:513-518|
|Bihorac, Azra; Ozrazgat-Baslanti, Tezcan; Ebadi, Ashkan et al. (2018) MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery. Ann Surg :|
|Ravyts, Scott G; Dzierzewski, Joseph M; Grah, Stephanie C et al. (2018) Sleep and Pain in Mid- to Late-Life: An Exploration of Day-to-Day Pain Inconsistency. Clin Gerontol 41:123-129|
Showing the most recent 10 out of 1197 publications