The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons' physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: ?mobility and prevention of disability.? Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC's general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: ? Leadership and Administrative Core; ? Research Education Core; ? Pilot/Exploratory Studies Core; ? Clinical Research Core; ? Metabolism and Translational Science Core; ? Biostatistics Core; and ? Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.
Better knowledge of the factors leading to optimizing mobility and developing efficacious and effective interventions to avert disability will have a major impact on practicing evidence-based geriatric medicine and public health.
|Guirgis, Faheem W; Dodani, Sunita; Moldawer, Lyle et al. (2017) Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation. Shock 48:539-544|
|Cruz-Almeida, Yenisel; Aguirre, Maria; Sorenson, Heather et al. (2017) Age differences in salivary markers of inflammation in response to experimental pain: does venipuncture matter? J Pain Res 10:2365-2372|
|Dhillon, Jess-Karan S; Riffe, Cara; Moore, Brenda D et al. (2017) A novel panel of ?-synuclein antibodies reveal distinctive staining profiles in synucleinopathies. PLoS One 12:e0184731|
|Layne, Andrew S; Krehbiel, Lisa M; Mankowski, Robert T et al. (2017) Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial. Contemp Clin Trials Commun 6:58-63|
|Evon, Donna M; Golin, Carol E; Stewart, Paul et al. (2017) Patient engagement and study design of PROP UP: A multi-site patient-centered prospective observational study of patients undergoing hepatitis C treatment. Contemp Clin Trials 57:58-68|
|Raymond, Steven L; López, María Cecilia; Baker, Henry V et al. (2017) Unique transcriptomic response to sepsis is observed among patients of different age groups. PLoS One 12:e0184159|
|Alamo, Ines G; Kannan, Kolenkode B; Loftus, Tyler J et al. (2017) Severe trauma and chronic stress activates extramedullary erythropoiesis. J Trauma Acute Care Surg 83:144-150|
|Millar, Jessica K; Kannan, Kolenkode B; Loftus, Tyler J et al. (2017) Persistent injury-associated anemia: the role of the bone marrow microenvironment. J Surg Res 214:240-246|
|Roy, Cindy N; Snyder, Peter J; Stephens-Shields, Alisa J et al. (2017) Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial. JAMA Intern Med 177:480-490|
|Loftus, Tyler J; Jordan, Janeen R; Croft, Chasen A et al. (2017) Characterization of hypoalbuminemia following temporary abdominal closure. J Trauma Acute Care Surg 83:650-656|
Showing the most recent 10 out of 917 publications