The Clinical Research Core (RC1) is key to the success of the University of Florida (UF) Older Americans Independence Center (OAIC). The RC1 provides the resources and expertise for conducting clinical research across the spectrum of investigation of clinical trials as well as observational studies of risk and outcomes related to mobility and the prevention of disability. Its primary goal is to encourage and facilitate clinical translational research in this area. The RC1 has three Specific Aims:
Aim 1 : Provide the resources and intellectual environment to facilitate clinical research, team science, and OAIC Junior Scholars' education related to mobility and the prevention of disability.
Aim 2 : Promote and facilitate the translation of preclinical and pilot studies into clinical trials in older persons.
Aim 3 : Improve our understanding of behavioral, cognitive, and physiological factors that may affect responses to interventions designed to improve mobility and prevent disability in older adults. The RC1 functions as the central hub to which the expertise, data and products of all OAIC cores converge to produce research projects ranging from pilot/ exploratory and developmental projects, to larger Phase II, III, and IV efficacy and effectiveness trials related to mobility and prevention of disability.The RC1 provides resources and personnel (including U01- and R01-funded investigators) to support the development and implementation of clinical trials. These include pharmacologic, nutritional, and behavioral interventions, and observational studies of the causes of mobility impairment in older adults and the implications for functional decline and disability. Building on close collaborations with other OAIC cores, the RC1 will support pilot/exploratory projects, developmental projects, and external projects. In addition, senior-level investigators with established track record will serve as career-development mentors to lead these projects, provide expertise, and promote a rich environment for junior-faculty research as well as senior-faculty collaboration.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Florida
Domestic Higher Education
United States
Zip Code
Chun, Sung Kook; Go, Kristina; Yang, Ming-Jim et al. (2016) Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicol Res 32:35-46
Loftus, Tyler J; Brakenridge, Scott C; Moore, Frederick A et al. (2016) Routine surveillance cholangiography following percutaneous cholecystostomy delays drain removal and cholecystectomy. J Trauma Acute Care Surg :
(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
Loftus, Tyler J; Jordan, Janeen R; Croft, Chasen A et al. (2016) Temporary abdominal closure for trauma and intra-abdominal sepsis: different patients, different outcomes. J Trauma Acute Care Surg :
Valiani, Vincenzo; Gao, Shiyao; Chen, Zhiguo et al. (2016) In-Hospital Mobility Variations Across Primary Diagnoses Among Older Adults. J Am Med Dir Assoc 17:465.e1-8
Mankowski, Robert T; Ahmed, Shakeel; Beaver, Thomas et al. (2016) Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study. J Transl Med 14:305
Bryant, Andrew J; Carrick, Ryan P; McConaha, Melinda E et al. (2016) Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 310:L249-62
Lopez, Maria-Cecilia; Efron, Philip A; Ozrazgat-Baslanti, Tezcan et al. (2016) Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock. J Trauma Acute Care Surg 81:478-85
Flores-Toro, Joseph A; Go, Kristina L; Leeuwenburgh, Christiaan et al. (2016) Autophagy in the liver: cell's cannibalism and beyond. Arch Pharm Res 39:1050-61
Valiani, Vincenzo; Corbett, Duane B; Knaggs, Jeffrey D et al. (2016) Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue. J Gerontol A Biol Sci Med Sci 71:1444-1450

Showing the most recent 10 out of 438 publications