RC-2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, metabolic syndrome, and acute events related to disability, such as stroke and hip fracture, occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The central hypothesis of RC-2 is that exercisefocused rehabilitation including aerobic and resistive training can improve multiple physiological systems in older, mobility limited individuals leading to improved functional performance, reduced cardiometabolic risk, and prevention of functional decline. This core focuses on the following specific aims: 1) To provide study support, mentor and train OAIC scholars, junior faculty and OAIC researchers in the performance of applied exercise physiology and tissue mechanisms research relevant to exercise-based restoration of function and prevention of functional declines in older people with chronic disabling diseases; 2) To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive medical research in aging and disability across the UM-OAIC pilot projects, RCDC Scholars'research and external NIH and VA funded research. We have combined two cores from our prior Pepper Centers into one more comprehensive core in this application that integrates bench and clinical research at the whole body and tissue level. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15 years. This core works synergistically with the other cores and research working groups to contribute to our fundamental understanding of the mechanisms by which exercise rehabilitation restores function, reduces metabolic risk and prevents functional decline in disabled individuals, as well as the mechanisms by which exercise rehabilitation enhances physical function and tissue metabolism.

Public Health Relevance

RC-2 will enhance efforts by UM-OAIC investigators to determine the whole body and tissue mechanisms by which exercise rehabilitation strategies enhance function and recovery in older adults with medical comorbidities and translate these exercise rehabilitation interventions into the community and clinical practice. The ultimate goal is having these new rehabilitation paradigms become part of the standard of care to increase independence in older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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University of Maryland Baltimore
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Kwon, Ivy; Bharmal, Nazleen; Choi, Sarah et al. (2016) Older Ethnic Minority Women's Perceptions of Stroke Prevention and Walking. Womens Health Issues 26:80-6
Loane, David J; Kumar, Alok (2016) Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol 275 Pt 3:316-27
Woytowicz, Elizabeth J; Rietschel, Jeremy C; Goodman, Ronald N et al. (2016) Determining Levels of Upper Extremity Movement Impairment by Applying a Cluster Analysis to the Fugl-Meyer Assessment of the Upper Extremity in Chronic Stroke. Arch Phys Med Rehabil :
Ryan, Alice S; Ivey, Frederick M; Serra, Monica C et al. (2016) Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors. Arch Phys Med Rehabil :
Anderson, Dennis E; Quinn, Emily; Parker, Emily et al. (2016) Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults. J Gerontol A Biol Sci Med Sci 71:811-6
Sanses, Tatiana V D; Schiltz, Nicholas K; Couri, Bruna M et al. (2016) Functional status in older women diagnosed with pelvic organ prolapse. Am J Obstet Gynecol 214:613.e1-7
Barton, Joseph E; Graci, Valentina; Hafer-Macko, Charlene et al. (2016) Dynamic Balanced Reach: A Temporal and Spectral Analysis Across Increasing Performance Demands. J Biomech Eng 138:
Resnick, Barbara; Beaupre, Lauren; McGilton, Katherine S et al. (2016) Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review. J Am Med Dir Assoc 17:200-5
Sacco, Paul; Smith, Cristan A; Harrington, Donna et al. (2016) Feasibility and Utility of Experience Sampling to Assess Alcohol Consumption Among Older Adults. J Appl Gerontol 35:106-20
Baxter, B Timothy; Matsumura, Jon; Curci, John et al. (2016) Non-invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT): Design of a Phase IIb, placebo-controlled, double-blind, randomized clinical trial of doxycycline for the reduction of growth of small abdominal aortic aneurysm. Contemp Clin Trials 48:91-8

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