The Mobility Function and Neuromotor Plasticity Core (RC-3) provides expertise and investigator resources to assess the multi-system neuromotor, blomeehanical, and motor behavioral factors affecting functional movement performance. RC-3 will assist and train RCDC Scholars and OAIC investigators in the design of novel rehabilitation interventions, conduct and interpretation of quantitative movement performance outcomes that are coupled to methodologies delineating the mechanisms of brain plasticity to advance the neuroscientific basis of functional recovery in older people with functional limitations. The Core supports: 1) a development project that examines the hypothesis that stabilizing responses to balance disturbances due to volitional movements primarily engage predictive and motor planning processes involving cortical and subcortical brain areas, while responses to reflexive balance disturbances due to unexpected external events primarily engage sensory feedback in the brainstem and spinal cord;2) a PES that decodes the cortical electrophyslology of gait in stroke and older controls to characterize the dynamic neuromotor plasticity of locomotion, and another that investigates effects of split belt treadmill on locomotor re-learning after stroke;and 3) RCDC Scholar who will be mentoring in biomechanics, EEG and neuroimaging methodologies to study mechanisms of balance and mobility dysfunction in older people. RC-3 collaborates across OAIC cores in nresearch working groups to advance the next generation of interventions to the community that will enhance mobility function in older adults with chronic disability. It performs quality controlled tests of gait, balance, postural control, upper limb activities, and functional tasks (Toolbox) that characterize the processes of neuromotor control and plasticity that underlie motor learning and exercise derived functional gains across OAIC interventions. During the last 5 years, RC-3 provided core services to five PES, one DP and 6 external projects, mentored 2 RCDC Scholars and advanced testing methodology in neuromotor control and neuroimaging as well as developing new intervention methodologies.

Public Health Relevance

Deterioration in multi-system motor functions affecting whole-body movement peri'ormance is a primary cause of mobility disability and loss of functional independence in older Americans that can be prevented and restored with rehabilitation interventions.The MFNP advances the conduct and mechanistic understanding of motor learning and exercise-based rehabilitation research focused on restoring and maintaining mnbilitv function of older neonle with reduce associated morbidity and mortality.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
United States
Zip Code
Kwon, Ivy; Bharmal, Nazleen; Choi, Sarah et al. (2016) Older Ethnic Minority Women's Perceptions of Stroke Prevention and Walking. Womens Health Issues 26:80-6
Loane, David J; Kumar, Alok (2016) Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol 275 Pt 3:316-27
Woytowicz, Elizabeth J; Rietschel, Jeremy C; Goodman, Ronald N et al. (2016) Determining Levels of Upper Extremity Movement Impairment by Applying a Cluster Analysis to the Fugl-Meyer Assessment of the Upper Extremity in Chronic Stroke. Arch Phys Med Rehabil :
Ryan, Alice S; Ivey, Frederick M; Serra, Monica C et al. (2016) Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors. Arch Phys Med Rehabil :
Anderson, Dennis E; Quinn, Emily; Parker, Emily et al. (2016) Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults. J Gerontol A Biol Sci Med Sci 71:811-6
Sanses, Tatiana V D; Schiltz, Nicholas K; Couri, Bruna M et al. (2016) Functional status in older women diagnosed with pelvic organ prolapse. Am J Obstet Gynecol 214:613.e1-7
Barton, Joseph E; Graci, Valentina; Hafer-Macko, Charlene et al. (2016) Dynamic Balanced Reach: A Temporal and Spectral Analysis Across Increasing Performance Demands. J Biomech Eng 138:
Resnick, Barbara; Beaupre, Lauren; McGilton, Katherine S et al. (2016) Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review. J Am Med Dir Assoc 17:200-5
Sacco, Paul; Smith, Cristan A; Harrington, Donna et al. (2016) Feasibility and Utility of Experience Sampling to Assess Alcohol Consumption Among Older Adults. J Appl Gerontol 35:106-20
Baxter, B Timothy; Matsumura, Jon; Curci, John et al. (2016) Non-invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT): Design of a Phase IIb, placebo-controlled, double-blind, randomized clinical trial of doxycycline for the reduction of growth of small abdominal aortic aneurysm. Contemp Clin Trials 48:91-8

Showing the most recent 10 out of 276 publications