RC-2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, metabolic syndrome, and acute events related to disability, such as stroke and hip fracture, occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The central hypothesis of RC-2 is that exercisefocused rehabilitation including aerobic and resistive training can improve multiple physiological systems in older, mobility limited individuals leading to improved functional performance, reduced cardiometabolic risk, and prevention of functional decline. This core focuses on the following specific aims: 1) To provide study support, mentor and train OAIC scholars, junior faculty and OAIC researchers in the performance of applied exercise physiology and tissue mechanisms research relevant to exercise-based restoration of function and prevention of functional declines in older people with chronic disabling diseases; 2) To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive medical research in aging and disability across the UM-OAIC pilot projects, RCDC Scholars'research and external NIH and VA funded research. We have combined two cores from our prior Pepper Centers into one more comprehensive core in this application that integrates bench and clinical research at the whole body and tissue level. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15 years. This core works synergistically with the other cores and research working groups to contribute to our fundamental understanding of the mechanisms by which exercise rehabilitation restores function, reduces metabolic risk and prevents functional decline in disabled individuals, as well as the mechanisms by which exercise rehabilitation enhances physical function and tissue metabolism.

Public Health Relevance

RC-2 will enhance efforts by UM-OAIC investigators to determine the whole body and tissue mechanisms by which exercise rehabilitation strategies enhance function and recovery in older adults with medical comorbidities and translate these exercise rehabilitation interventions into the community and clinical practice. The ultimate goal is having these new rehabilitation paradigms become part of the standard of care to increase independence in older adults.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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University of Maryland Baltimore
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Stookey, Alyssa D; Katzel, Leslie I; Steinbrenner, Gregory et al. (2014) The short physical performance battery as a predictor of functional capacity after stroke. J Stroke Cerebrovasc Dis 23:130-5
Barton, Joseph E; Sorkin, John D (2014) Design and evaluation of prosthetic shoulder controller. J Rehabil Res Dev 51:711-26
Addison, Odessa; Young, Patricia; Inacio, Mario et al. (2014) Hip but not thigh intramuscular adipose tissue is associated with poor balance and increased temporal gait variability in older adults. Curr Aging Sci 7:137-43
Prior, Steven J; Ryan, Alice S; Stevenson, Troy G et al. (2014) Metabolic inflexibility during submaximal aerobic exercise is associated with glucose intolerance in obese older adults. Obesity (Silver Spring) 22:451-7
Landers-Ramos, Rian Q; Jenkins, Nathan T; Spangenburg, Espen E et al. (2014) Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men. Eur J Appl Physiol 114:1377-84
Ge, Shealinna; Ryan, Alice S (2014) Zinc-?2-glycoprotein expression in adipose tissue of obese postmenopausal women before and after weight loss and exercise + weight loss. Metabolism 63:995-9
Inacio, Mario; Ryan, Alice S; Bair, Woei-Nan et al. (2014) Gluteal muscle composition differentiates fallers from non-fallers in community dwelling older adults. BMC Geriatr 14:37
Verceles, Avelino C; Corwin, Douglas S; Afshar, Majid et al. (2014) Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med 40:1124-31
Koldobskiy, Dafna; Diaz-Abad, Montserrat; Scharf, Steven M et al. (2014) Long-term acute care patients weaning from prolonged mechanical ventilation maintain circadian rhythm. Respir Care 59:518-24
Prior, Steven J; Blumenthal, Jacob B; Katzel, Leslie I et al. (2014) Increased skeletal muscle capillarization after aerobic exercise training and weight loss improves insulin sensitivity in adults with IGT. Diabetes Care 37:1469-75

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