The goal of the Pilot/Exploratory Studies Core (PESC) is to promote innovative multidisciplinary research focused on the mechanisms underlying disability, recovery and prevention in older persons and the functional and clinical responses to rehabilitation. The PESC manages the process of promotion, application, review, award and monitoring for Pilot and Exploratory Studies (PES). Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. The priori 5-year history of outstanding research productivity and academic accomplishments of pilot investigators attests to our excellent environment, mentors and academic resources in support of PES. This OAIC has made 58 pilot grant awards since its inception in 1994. Success of PESC is demonstrated by the 23 pilots funded in the 2000-2005 OAIC for $460,000 that have yielded over $2.8 million in extramural funding. During the last 5 years, PESC invested $371,000 in 16 pilot studies that have to date generated 25 publications and ~ $2.9 million in extramural funding. PESC funding and mentorship of junior faculty and others in the conduct of PES's is essential to improve the rehabilitation outcomes and recovery of older people with chronic disabling diseases and advance the field of exercisebased rehabilitation with new academic leaders. Proposed first year pilot studies include PES-1: Improving walking symmetry and functional mobility in stroke survivors with split-belt treadmill training;PES-2: Aerobic exercise to improve regulation of EPCs and vascular function in T2DM;PES-3: Effects of Vitamin D Repletion (D) with and without Multicomponent Lifestyle Exercise Training (MLife) on Muscle Function, Inflammation and Glucose Metabolism in D Deficient OlderAdults;PES-4: Resistance Training (RT) and Protein (Pro) Supplementation to Improve Muscle Physiology and Reduce Fatigue in Breast Cancer Survivors;PES-5: A High-Density Electroencephalography (EEG) Neural Decoding Study of Dynamical Cortical Mapping of Gait in Humans After Stroke.

Public Health Relevance

PES's are essential to stimulate new interdisciplinary collaborations and to attract new and established investigators from relevant disciplines to study rehabilitation science, human physiology, neuropsychology and metabolism- related research. They will contribute to the fulfillment of Healthy People for older Americans to prevent the progression of chronic disease and disability with aging and enhance the functinnal indepedence of older people with progressive disability.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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University of Maryland Baltimore
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Kwon, Ivy; Bharmal, Nazleen; Choi, Sarah et al. (2016) Older Ethnic Minority Women's Perceptions of Stroke Prevention and Walking. Womens Health Issues 26:80-6
Loane, David J; Kumar, Alok (2016) Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol 275 Pt 3:316-27
Woytowicz, Elizabeth J; Rietschel, Jeremy C; Goodman, Ronald N et al. (2016) Determining Levels of Upper Extremity Movement Impairment by Applying a Cluster Analysis to the Fugl-Meyer Assessment of the Upper Extremity in Chronic Stroke. Arch Phys Med Rehabil :
Ryan, Alice S; Ivey, Frederick M; Serra, Monica C et al. (2016) Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors. Arch Phys Med Rehabil :
Anderson, Dennis E; Quinn, Emily; Parker, Emily et al. (2016) Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults. J Gerontol A Biol Sci Med Sci 71:811-6
Sanses, Tatiana V D; Schiltz, Nicholas K; Couri, Bruna M et al. (2016) Functional status in older women diagnosed with pelvic organ prolapse. Am J Obstet Gynecol 214:613.e1-7
Barton, Joseph E; Graci, Valentina; Hafer-Macko, Charlene et al. (2016) Dynamic Balanced Reach: A Temporal and Spectral Analysis Across Increasing Performance Demands. J Biomech Eng 138:
Resnick, Barbara; Beaupre, Lauren; McGilton, Katherine S et al. (2016) Rehabilitation Interventions for Older Individuals With Cognitive Impairment Post-Hip Fracture: A Systematic Review. J Am Med Dir Assoc 17:200-5
Sacco, Paul; Smith, Cristan A; Harrington, Donna et al. (2016) Feasibility and Utility of Experience Sampling to Assess Alcohol Consumption Among Older Adults. J Appl Gerontol 35:106-20
Baxter, B Timothy; Matsumura, Jon; Curci, John et al. (2016) Non-invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT): Design of a Phase IIb, placebo-controlled, double-blind, randomized clinical trial of doxycycline for the reduction of growth of small abdominal aortic aneurysm. Contemp Clin Trials 48:91-8

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