The goal of the Pilot/Exploratory Studies Core (PESC) is to promote innovative multidisciplinary research focused on the mechanisms underlying disability, recovery and prevention in older persons and the functional and clinical responses to rehabilitation. The PESC manages the process of promotion, application, review, award and monitoring for Pilot and Exploratory Studies (PES). Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. The priori 5-year history of outstanding research productivity and academic accomplishments of pilot investigators attests to our excellent environment, mentors and academic resources in support of PES. This OAIC has made 58 pilot grant awards since its inception in 1994. Success of PESC is demonstrated by the 23 pilots funded in the 2000-2005 OAIC for $460,000 that have yielded over $2.8 million in extramural funding. During the last 5 years, PESC invested $371,000 in 16 pilot studies that have to date generated 25 publications and ~ $2.9 million in extramural funding. PESC funding and mentorship of junior faculty and others in the conduct of PES's is essential to improve the rehabilitation outcomes and recovery of older people with chronic disabling diseases and advance the field of exercisebased rehabilitation with new academic leaders. Proposed first year pilot studies include PES-1: Improving walking symmetry and functional mobility in stroke survivors with split-belt treadmill training;PES-2: Aerobic exercise to improve regulation of EPCs and vascular function in T2DM;PES-3: Effects of Vitamin D Repletion (D) with and without Multicomponent Lifestyle Exercise Training (MLife) on Muscle Function, Inflammation and Glucose Metabolism in D Deficient OlderAdults;PES-4: Resistance Training (RT) and Protein (Pro) Supplementation to Improve Muscle Physiology and Reduce Fatigue in Breast Cancer Survivors;PES-5: A High-Density Electroencephalography (EEG) Neural Decoding Study of Dynamical Cortical Mapping of Gait in Humans After Stroke.

Public Health Relevance

PES's are essential to stimulate new interdisciplinary collaborations and to attract new and established investigators from relevant disciplines to study rehabilitation science, human physiology, neuropsychology and metabolism- related research. They will contribute to the fulfillment of Healthy People for older Americans to prevent the progression of chronic disease and disability with aging and enhance the functinnal indepedence of older people with progressive disability.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8)
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University of Maryland Baltimore
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Ritzel, Rodney M; Doran, Sarah J; Barrett, James P et al. (2018) Chronic Alterations in Systemic Immune Function after Traumatic Brain Injury. J Neurotrauma 35:1419-1436
Rathbun, A M; Magaziner, J; Shardell, M D et al. (2018) Older men who sustain a hip fracture experience greater declines in bone mineral density at the contralateral hip than non-fractured comparators. Osteoporos Int 29:365-373
Addison, Odessa; Kundi, Rishi; Ryan, Alice S et al. (2018) Clinical relevance of the modified physical performance test versus the short physical performance battery for detecting mobility impairments in older men with peripheral arterial disease. Disabil Rehabil 40:3081-3085
Yimgang, Doris P; Sorkin, John D; Evans, Charles F et al. (2018) Angiotensin converting enzyme inhibitors and interstage failure in infants with hypoplastic left heart syndrome. Congenit Heart Dis 13:533-540
Salimi, Shabnam; Shardell, Michelle; Miller, Ram et al. (2018) Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption, and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies. J Bone Miner Res 33:1649-1656
Ryan, Alice S; Serra, Monica C; Goldberg, Andrew P (2018) Metabolic Benefits of Prior Weight Loss with and without Exercise on Subsequent 6-Month Weight Regain. Obesity (Silver Spring) 26:37-44
Verceles, Avelino C; Wells, Chris L; Sorkin, John D et al. (2018) A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home. J Crit Care 47:204-210
Addison, Odessa; Prior, Steven J; Kundi, Rishi et al. (2018) Sarcopenia in Peripheral Arterial Disease: Prevalence and Effect on Functional Status. Arch Phys Med Rehabil 99:623-628
Serra, Monica C; Ryan, Alice S; Ortmeyer, Heidi K et al. (2018) Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors. Menopause 25:211-216
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961

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