The goal of the Pilot/Exploratory Studies Core (PESC) is to promote innovative multidisciplinary research focused on the mechanisms underlying disability, recovery and prevention in older persons and the functional and clinical responses to rehabilitation. The PESC manages the process of promotion, application, review, award and monitoring for Pilot and Exploratory Studies (PES). Priorities for awards include relevance to the OAIC theme, potential for independent funding, new multidisciplinary collaboration and translational potential. The priori 5-year history of outstanding research productivity and academic accomplishments of pilot investigators attests to our excellent environment, mentors and academic resources in support of PES. This OAIC has made 58 pilot grant awards since its inception in 1994. Success of PESC is demonstrated by the 23 pilots funded in the 2000-2005 OAIC for $460,000 that have yielded over $2.8 million in extramural funding. During the last 5 years, PESC invested $371,000 in 16 pilot studies that have to date generated 25 publications and ~ $2.9 million in extramural funding. PESC funding and mentorship of junior faculty and others in the conduct of PES's is essential to improve the rehabilitation outcomes and recovery of older people with chronic disabling diseases and advance the field of exercisebased rehabilitation with new academic leaders. Proposed first year pilot studies include PES-1: Improving walking symmetry and functional mobility in stroke survivors with split-belt treadmill training;PES-2: Aerobic exercise to improve regulation of EPCs and vascular function in T2DM;PES-3: Effects of Vitamin D Repletion (D) with and without Multicomponent Lifestyle Exercise Training (MLife) on Muscle Function, Inflammation and Glucose Metabolism in D Deficient OlderAdults;PES-4: Resistance Training (RT) and Protein (Pro) Supplementation to Improve Muscle Physiology and Reduce Fatigue in Breast Cancer Survivors;PES-5: A High-Density Electroencephalography (EEG) Neural Decoding Study of Dynamical Cortical Mapping of Gait in Humans After Stroke.

Public Health Relevance

PES's are essential to stimulate new interdisciplinary collaborations and to attract new and established investigators from relevant disciplines to study rehabilitation science, human physiology, neuropsychology and metabolism- related research. They will contribute to the fulfillment of Healthy People for older Americans to prevent the progression of chronic disease and disability with aging and enhance the functinnal indepedence of older people with progressive disability.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG028747-09
Application #
8688860
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
$218,353
Indirect Cost
$72,784
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Serra, Monica C; Ryan, Alice S; Ortmeyer, Heidi K et al. (2018) Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors. Menopause 25:211-216
Miller, Michael E; Magaziner, Jay; Marsh, Anthony P et al. (2018) Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations. J Am Geriatr Soc 66:954-961
Quinn, Charlene Connolly; Butler, Erin C; Swasey, Krystal K et al. (2018) Mobile Diabetes Intervention Study of Patient Engagement and Impact on Blood Glucose: Mixed Methods Analysis. JMIR Mhealth Uhealth 6:e31
Beaupre, Lauren A; Wai, Eugene K; Hoover, Donald R et al. (2018) A comparison of outcomes between Canada and the United States in patients recovering from hip fracture repair: secondary analysis of the FOCUS trial. Int J Qual Health Care 30:97-103
Rathbun, Alan M; Shardell, Michelle D; Stuart, Elizabeth A et al. (2018) Persistence of depressive symptoms and gait speed recovery in older adults after hip fracture. Int J Geriatr Psychiatry 33:875-882
Oursler, Krisann K; Sorkin, John D; Ryan, Alice S et al. (2018) A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV. PLoS One 13:e0198855
Verceles, Avelino C; Bhatti, Waqas (2018) The Ethical Concerns of Seeking Consent from Critically Ill, Mechanically Ventilated Patients for Research - A Matter of Possessing Capacity or Surrogate Insight. Clin Ethics 13:107-111
Leiter, Nikita; Motta, Melissa; Reed, Robert M et al. (2018) Numeracy and Interpretation of Prognostic Estimates in Intracerebral Hemorrhage Among Surrogate Decision Makers in the Neurologic ICU. Crit Care Med 46:264-271
Blanco, Natalia; Johnson, J Kristie; Sorkin, John D et al. (2018) Transmission of resistant Gram-negative bacteria to healthcare personnel gowns and gloves during care of residents in community-based nursing facilities. Infect Control Hosp Epidemiol 39:1425-1430
Spanakis, Elias K; Levitt, David L; Siddiqui, Tariq et al. (2018) The Effect of Continuous Glucose Monitoring in Preventing Inpatient Hypoglycemia in General Wards: The Glucose Telemetry System. J Diabetes Sci Technol 12:20-25

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