Remarkable progress in genomic research is leading to a complete map of the building blocks of biology. Knowledge of this map is, in turn, fueling the study of gene regulation, where proteins often regulate their own production or that of other proteins in a complex web of interactions. An important challenge in post-genomic aging research will be the dissection and analysis of the complex gene regulatory networks involved in aging processes and function promoting anabolic therapies, and the deduction of phenotypic cellular responses from the structure and behavior of such networks. The implications of the underlying logic of genetic networks are difficult to deduce through experimental techniques alone, and successful approaches will, in many cases, involve the union of new experiments and computational modeling techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG031679-05
Application #
8378991
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$74,568
Indirect Cost
$19,491
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Travison, Thomas G; Vesper, Hubert W; Orwoll, Eric et al. (2017) Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe. J Clin Endocrinol Metab 102:1161-1173
Roy, Cindy N; Snyder, Peter J; Stephens-Shields, Alisa J et al. (2017) Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial. JAMA Intern Med 177:480-490
Mankowski, Robert T; Anton, Stephen D; Axtell, Robert et al. (2017) Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. J Am Geriatr Soc 65:2251-2256
Storer, Thomas W; Basaria, Shehzad; Traustadottir, Tinna et al. (2017) Effects of Testosterone Supplementation for 3 Years on Muscle Performance and Physical Function in Older Men. J Clin Endocrinol Metab 102:583-593
Santanasto, Adam J; Glynn, Nancy W; Lovato, Laura C et al. (2017) Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility. J Am Geriatr Soc 65:1427-1433
Fielding, Roger A; Guralnik, Jack M; King, Abby C et al. (2017) Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial. PLoS One 12:e0182155
Kritchevsky, Stephen B; Lovato, Laura; Handing, Elizabeth P et al. (2017) Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial. Obesity (Silver Spring) 25:1199-1205
Chen, Haiying; Ambrosius, Walter T; Murphy, Terrence E et al. (2017) Imputation of Gait Speed for Noncompleters in the 400-Meter Walk: Application to the Lifestyle Interventions for Elders Study. J Am Geriatr Soc 65:2566-2571
Snyder, Peter J; Kopperdahl, David L; Stephens-Shields, Alisa J et al. (2017) Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial. JAMA Intern Med 177:471-479
Wanigatunga, Amal A; Tudor-Locke, Catrine; Axtell, Robert S et al. (2017) Effects of a Long-Term Physical Activity Program on Activity Patterns in Older Adults. Med Sci Sports Exerc 49:2167-2175

Showing the most recent 10 out of 165 publications