The Data Management and Statistics (DMS) Core (Core C) will provide support for The University of Kansas Alzheimer's Disease Core Center (KU ADCC). The DMS Core personnel are faculty and staff of the Department of Biostatistics with the training and experience to support the research needs investigators that will utilized the KU ADCC. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective, we will utilize our web-based Comprehensive Research Information System, or CRIS. We will also support Alzheimer's Disease research by providing statistical expertise for projects that utilize the KU ADCC. Thus, the DMS Core has the following specific aims.
Aim 1 : Develop Data and Information Management and Monitoring Systems. We will provide support systems to KU ADCC cores and research projects. We will provide data to investigators and to the National Alzheimer's Disease Coordinating Center.
Aim 2 : Provide Statistical Expertise for ADCC Projects. The DMS Core will support the design, statistical oversight, and analysis of study data for KU ADCC projects. This will include participation in study presentations and publications. When needed, the DMS Core will also develop novel statistical methodology to ensure the appropriate characterization of study data.
Aim 3 : Provide a Liaison between Cores with Other Cores and Research Projects. Much of the activity in and with the KU ADCC will involve data collected by the KU ADCC, data management, information management, and/or statistical support. This intersection of the DMS Core across the KU ADCC make it a natural liaison for core-to-core and core-to-investigator activities.
In most research, proper data management and use of statistics are critical to the proper interpretation of study results. The Data Management and Statistics Core (Core C) strives to: provide the highest quality, cutting-edge study design;perform accurate power and sample size calculations;conduct appropriate analyses of data;and provide the data management and informatics support to aid in Alzheimer's research.
|Wilkins, Heather M; Swerdlow, Russell H (2016) Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease. Curr Top Med Chem 16:849-57|
|LoBue, Christian; Denney, David; Hynan, Linda S et al. (2016) Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. J Alzheimers Dis 51:727-36|
|Dardis, A; Zampieri, S; Canterini, S et al. (2016) Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C. Acta Neuropathol Commun 4:52|
|Lai, Dongbing; Xu, Huiping; Koller, Daniel et al. (2016) A MULTIVARIATE FINITE MIXTURE LATENT TRAJECTORY MODEL WITH APPLICATION TO DEMENTIA STUDIES. J Appl Stat 43:2503-2523|
|Ahmed, Ali Bani; Cirstea, Carmen M (2016) Positive Effect of Impairment-Oriented Training on N-Acetylaspartate Levels of Ipsilesional Motor Cortex in Subcortical Stroke: A Case Study. Int J Phys Med Rehabil 4:|
|Day, Gregory S; Musiek, Erik S; Roe, Catherine M et al. (2016) Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol 73:1125-32|
|Ronquillo, Jay Geronimo; Baer, Merritt Rachel; Lester, William T (2016) Sex-specific patterns and differences in dementia and Alzheimer's disease using informatics approaches. J Women Aging 28:403-11|
|Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90|
|Wilkins, Heather M; Koppel, Scott; Carl, Steven M et al. (2016) Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure. J Neurochem 137:76-87|
|Besser, Lilah M; Alosco, Michael L; Ramirez Gomez, Liliana et al. (2016) Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol 75:955-962|
Showing the most recent 10 out of 173 publications