The Data Management and Statistics (DMS) Core (Core C) will provide support for The University of Kansas Alzheimer's Disease Core Center (KU ADCC). The DMS Core personnel are faculty and staff of the Department of Biostatistics with the training and experience to support the research needs investigators that will utilized the KU ADCC. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective, we will utilize our web-based Comprehensive Research Information System, or CRIS. We will also support Alzheimer's Disease research by providing statistical expertise for projects that utilize the KU ADCC. Thus, the DMS Core has the following specific aims.
Aim 1 : Develop Data and Information Management and Monitoring Systems. We will provide support systems to KU ADCC cores and research projects. We will provide data to investigators and to the National Alzheimer's Disease Coordinating Center.
Aim 2 : Provide Statistical Expertise for ADCC Projects. The DMS Core will support the design, statistical oversight, and analysis of study data for KU ADCC projects. This will include participation in study presentations and publications. When needed, the DMS Core will also develop novel statistical methodology to ensure the appropriate characterization of study data.
Aim 3 : Provide a Liaison between Cores with Other Cores and Research Projects. Much of the activity in and with the KU ADCC will involve data collected by the KU ADCC, data management, information management, and/or statistical support. This intersection of the DMS Core across the KU ADCC make it a natural liaison for core-to-core and core-to-investigator activities.

Public Health Relevance

In most research, proper data management and use of statistics are critical to the proper interpretation of study results. The Data Management and Statistics Core (Core C) strives to: provide the highest quality, cutting-edge study design;perform accurate power and sample size calculations;conduct appropriate analyses of data;and provide the data management and informatics support to aid in Alzheimer's research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG035982-03
Application #
8501215
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$157,211
Indirect Cost
$52,403
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Alosco, Michael L; Duskin, Jonathan; Besser, Lilah M et al. (2017) Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis 57:953-968
Grill, Joshua D; Apostolova, Liana G; Bullain, Szofia et al. (2017) Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther 9:35
Pandya, Seema Y; Lacritz, Laura H; Weiner, Myron F et al. (2017) Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition. Dement Geriatr Cogn Disord 43:204-214
Katsumata, Yuriko; Nelson, Peter T; Ellingson, Sally R et al. (2017) Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging 53:193.e17-193.e25
Wilkins, Heather M; Koppel, Scott J; Bothwell, Rebecca et al. (2017) Platelet cytochrome oxidase and citrate synthase activities in APOE ?4 carrier and non-carrier Alzheimer's disease patients. Redox Biol 12:828-832
Wilkins, Heather M; Weidling, Ian W; Ji, Yan et al. (2017) Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration. Front Immunol 8:508
Fu, Xian; Adams, Zachary; Liu, Rui et al. (2017) Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea. MBio 8:
Manley, Sharon J; Liu, Wen; Welch, Danny R (2017) The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation. J Mol Med (Berl) 95:951-963
Jutkowitz, Eric; MacLehose, Richard F; Gaugler, Joseph E et al. (2017) Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients. J Gerontol A Biol Sci Med Sci 72:251-258
Kim, Julia; Schweizer, Tom A; Fischer, Corinne E et al. (2017) The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer's Disease. J Alzheimers Dis 55:381-389

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