The Data Management and Statistics (DMS) Core (Core C) will provide support for The University of Kansas Alzheimer's Disease Core Center (KU ADCC). The DMS Core personnel are faculty and staff of the Department of Biostatistics with the training and experience to support the research needs investigators that will utilized the KU ADCC. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective, we will utilize our web-based Comprehensive Research Information System, or CRIS. We will also support Alzheimer's Disease research by providing statistical expertise for projects that utilize the KU ADCC. Thus, the DMS Core has the following specific aims.
Aim 1 : Develop Data and Information Management and Monitoring Systems. We will provide support systems to KU ADCC cores and research projects. We will provide data to investigators and to the National Alzheimer's Disease Coordinating Center.
Aim 2 : Provide Statistical Expertise for ADCC Projects. The DMS Core will support the design, statistical oversight, and analysis of study data for KU ADCC projects. This will include participation in study presentations and publications. When needed, the DMS Core will also develop novel statistical methodology to ensure the appropriate characterization of study data.
Aim 3 : Provide a Liaison between Cores with Other Cores and Research Projects. Much of the activity in and with the KU ADCC will involve data collected by the KU ADCC, data management, information management, and/or statistical support. This intersection of the DMS Core across the KU ADCC make it a natural liaison for core-to-core and core-to-investigator activities.

Public Health Relevance

In most research, proper data management and use of statistics are critical to the proper interpretation of study results. The Data Management and Statistics Core (Core C) strives to: provide the highest quality, cutting-edge study design;perform accurate power and sample size calculations;conduct appropriate analyses of data;and provide the data management and informatics support to aid in Alzheimer's research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kansas
Kansas City
United States
Zip Code
Kim, Jieun; Choi, In-Young; Dong, Yafeng et al. (2015) Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: A longitudinal diffusion tensor imaging and T2 mapping study. J Magn Reson Imaging 42:658-65
Vidoni, Eric D; Burns, Jeffrey M (2015) Exercise programmes for older people with dementia may have an effect on cognitive function and activities of daily living, but studies give inconsistent results. Evid Based Nurs 18:4
Selfridge, J Eva; Wilkins, Heather M; E, Lezi et al. (2015) Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr 47:11-Jan
Gras, Laura Z; Kanaan, Saddam F; McDowd, Joan M et al. (2015) Balance and gait of adults with very mild Alzheimer disease. J Geriatr Phys Ther 38:7-Jan
Vangavaragu, Jhansi Rani; Valasani, Koteswara Rao; Fang, Du et al. (2014) Determination of small molecule ABAD inhibitors crossing blood-brain barrier and pharmacokinetics. J Alzheimers Dis 42:333-44
Harris, Janna L; Yeh, Hung-Wen; Swerdlow, Russell H et al. (2014) High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol Aging 35:1686-94
Gan, Xueqi; Huang, Shengbin; Wu, Long et al. (2014) Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell. Biochim Biophys Acta 1842:220-31
Morris, Jill K; Honea, Robyn A; Vidoni, Eric D et al. (2014) Is Alzheimer's disease a systemic disease? Biochim Biophys Acta 1842:1340-9
Esteves, A Raquel; Swerdlow, Russell H; Cardoso, Sandra M (2014) LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis. Exp Neurol 261:206-16
Jiang, Lei; Bechtel, Misty D; Bean, Jennifer L et al. (2014) Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase. Biochim Biophys Acta 1838:1255-65

Showing the most recent 10 out of 56 publications