The overall goal of the University of Kansas Alzheimer's Disease Core Center (KU ADCC) Neuromaging Core is to enhance the neuroimaging infrastructure and facilitate increased research in aging and Alzheimer's disease for researchers at the University of Kansas and nearby institutions. The Neuroimaging Core builds on the established resources of the (i) KU Hoglund Brain Imaging Center that brings together, in a specialized research building, a unique array of human (3 Tesla) and animal (9.4 Tesla) MRI and cortical (151 channel) and fetal (83 channel) magnetoencephalography (MEG), and the (ii) KU Hospital that provides positron emission tomography as well as a strong faculty of imaging scientists with outstanding experience across the modalities. Accordingly, the Neuroimaging Core is ideally resourced to support current and future investigators who use imaging as a research tool. This goal will be achieved through three specific aims that provide (i) state-of-the-art imaging facilities and professional neuroimaging support, (ii) advanced education in imaging sciences and (iii) novel imaging approaches to AD investigators of the University of Kansas, the state of Kansas, and the Kansas City metropolitan area.
The Specific Aims of the KU ADCC Neuroimaging Core are Aim 1. Provide an integrated imaging environment with advanced scientific support and subsidized scans for AD research Aim 2. Provide advanced training, and education in imaging for ADCC investigators.
Aim 3. Develop novel imaging techniques for studies in AD.

Public Health Relevance

Neuroimaging provides a non-invasive means to measure structure and function of the living human brain. The Neuroimaging Core will support scientists investigating Alzheimer's and other neurodegenerative diseases of aging by providing access to state-of-the-art imaging, education and training in imaging modalities, and novel imaging methods.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG035982-03
Application #
8501218
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$75,228
Indirect Cost
$25,075
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Kim, Jieun; Choi, In-Young; Dong, Yafeng et al. (2015) Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: A longitudinal diffusion tensor imaging and T2 mapping study. J Magn Reson Imaging 42:658-65
Vidoni, Eric D; Burns, Jeffrey M (2015) Exercise programmes for older people with dementia may have an effect on cognitive function and activities of daily living, but studies give inconsistent results. Evid Based Nurs 18:4
Selfridge, J Eva; Wilkins, Heather M; E, Lezi et al. (2015) Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr 47:11-Jan
Gras, Laura Z; Kanaan, Saddam F; McDowd, Joan M et al. (2015) Balance and gait of adults with very mild Alzheimer disease. J Geriatr Phys Ther 38:7-Jan
Vangavaragu, Jhansi Rani; Valasani, Koteswara Rao; Fang, Du et al. (2014) Determination of small molecule ABAD inhibitors crossing blood-brain barrier and pharmacokinetics. J Alzheimers Dis 42:333-44
Harris, Janna L; Yeh, Hung-Wen; Swerdlow, Russell H et al. (2014) High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol Aging 35:1686-94
Gan, Xueqi; Huang, Shengbin; Wu, Long et al. (2014) Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell. Biochim Biophys Acta 1842:220-31
Morris, Jill K; Honea, Robyn A; Vidoni, Eric D et al. (2014) Is Alzheimer's disease a systemic disease? Biochim Biophys Acta 1842:1340-9
Esteves, A Raquel; Swerdlow, Russell H; Cardoso, Sandra M (2014) LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis. Exp Neurol 261:206-16
Jiang, Lei; Bechtel, Misty D; Bean, Jennifer L et al. (2014) Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase. Biochim Biophys Acta 1838:1255-65

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