The overall goal of the Clinical Core is to provide University of Kansas (KU) Alzheimer's Disease Core Center (ADCC) investigators with access to a well-characterized cohort of research participants with and without dementia. The Clinical Core will continue to emphasize recruiting nondemented individuals and those in the earliest symptomatic stages of AD, including mild cognitive impairment (MCI). This overall goal will be met by the following specific aims:
Aim 1. Maintain an active cohort of nondemented, mild cognitive impairment (MCI) and AD subjects to support cross-sectional and longitudinal studies.
Aim 2. Support and encourage collaborative interdisciplinary studies on AD and aging by providing data, biological specimens, and clinical research infrastructure, expertise and support to approved investigators and national data sharing initiatives (i.e., NACC). The initiation of the Clinical Core in 2004 (previously known as the Alzheimer and Memory Program) has stimulated the growth of AD and aging research at KU. In six years, the program has significantly broadened the base of AD investigators by stimulating collaborative studies, providing a training environment for the next generation of AD investigators, and by attracting new faculty to the campus. The Clinical Core has developed essential infrastructure and participant recruitment capabilities that directly supports the research efforts of faculty members in the Schools of Medicine, Allied Health, and Nursing. The research and training foundation of the Clinical Core will provide KU investigators with the infrastructure to build on this history and pursue the novel role of metabolic dysfunction in neurodegeneration and aging.
With the aging population, age-related disorders such as dementia are rising in prevalence at an unprecedented rate. Prompting and supporting clinical and translational research into neurodegenerative disorders may lead to important prevention and treatment strategies.
|Kim, Jieun; Choi, In-Young; Dong, Yafeng et al. (2015) Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: A longitudinal diffusion tensor imaging and T2 mapping study. J Magn Reson Imaging 42:658-65|
|Vidoni, Eric D; Burns, Jeffrey M (2015) Exercise programmes for older people with dementia may have an effect on cognitive function and activities of daily living, but studies give inconsistent results. Evid Based Nurs 18:4|
|Selfridge, J Eva; Wilkins, Heather M; E, Lezi et al. (2015) Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr 47:11-Jan|
|Gras, Laura Z; Kanaan, Saddam F; McDowd, Joan M et al. (2015) Balance and gait of adults with very mild Alzheimer disease. J Geriatr Phys Ther 38:7-Jan|
|Vangavaragu, Jhansi Rani; Valasani, Koteswara Rao; Fang, Du et al. (2014) Determination of small molecule ABAD inhibitors crossing blood-brain barrier and pharmacokinetics. J Alzheimers Dis 42:333-44|
|Harris, Janna L; Yeh, Hung-Wen; Swerdlow, Russell H et al. (2014) High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol Aging 35:1686-94|
|Gan, Xueqi; Huang, Shengbin; Wu, Long et al. (2014) Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell. Biochim Biophys Acta 1842:220-31|
|Morris, Jill K; Honea, Robyn A; Vidoni, Eric D et al. (2014) Is Alzheimer's disease a systemic disease? Biochim Biophys Acta 1842:1340-9|
|Esteves, A Raquel; Swerdlow, Russell H; Cardoso, Sandra M (2014) LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis. Exp Neurol 261:206-16|
|Jiang, Lei; Bechtel, Misty D; Bean, Jennifer L et al. (2014) Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase. Biochim Biophys Acta 1838:1255-65|
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