Human genetic research has made remarkable progress in understanding the underlying genetic architecture of numerous human genetic traits. The underlying genetic lesions for thousands of Mendelian traits have now been identified and hundreds of associations with common polymorphisms have now been described using genome-wide association studies (GWAS). Among these successes are numerous traits of aging, including dementia, Parkinson disease, macular degeneration, and successful aging, to name just a few. However, these studies have just begun the job of describing in detail the genetic architecture of traits of aging, as even for the intensively studied dementias, only a minority of the risk architecture has been described. The goal of this P30 Core application is to support the recruitment and start-up activities of a new tenure track faculty member in the Vanderbilt University School of Medicine. The focus of this individual's research will be the neurogenetics of aging, with a further focus on human genetics. They will have an appointment within the Division of Human Genomics (DHG), Department of Molecular Physiology and Biophysics in the School of Medicine, Vanderbilt University. They will also be appointed as an Investigator within the Center for Human Genetics Research (CHGR), the primary location for their research activities. They will have access to superlative core resources, collaborations and mentoring. Our goal is to identify and recruit an outstanding candidate who will complement the current expertise within the DHG and the CHGR and perform ground-breaking research in the neurogenetics of aging. To achieve this goal, we specifically propose to recruit internationally to identify a large pool of qualified applicants, select the best possible candidate, provide start-up resources and a collaborative atmosphere, and provide exemplary mentoring to guide this individual through their first years as a faculty member.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG036445-02
Application #
7935396
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (O5))
Program Officer
Miller, Marilyn
Project Start
2009-09-30
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$490,000
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-150
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
Vega, Jennifer N; Hohman, Timothy J; Pryweller, Jennifer R et al. (2015) Resting-State Functional Connectivity in Individuals with Down Syndrome and Williams Syndrome Compared with Typically Developing Controls. Brain Connect 5:461-75
Hohman, Timothy J; Koran, Mary Ellen I; Thornton-Wells, Tricia A et al. (2014) Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Alzheimers Dement 10:637-645.e1
Hohman, Timothy J; Koran, Mary Ellen I; Thornton-Wells, Tricia A et al. (2014) Genetic variation modifies risk for neurodegeneration based on biomarker status. Front Aging Neurosci 6:183
Koran, Mary Ellen I; Hohman, Timothy J; Meda, Shashwath A et al. (2014) Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. J Alzheimers Dis 38:145-54
Koran, Mary Ellen I; Hohman, Timothy J; Thornton-Wells, Tricia A (2014) Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Hum Genet 133:85-93
Hohman, Timothy J; Koran, Mary Ellen I; Thornton-Wells, Tricia A et al. (2014) Interactions between GSK3? and amyloid genes explain variance in amyloid burden. Neurobiol Aging 35:460-5
Bruehl, Stephen; Denton, Jerod S; Lonergan, Daniel et al. (2013) Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes. Pain 154:2853-9
Samuels, David C; Li, Chun; Li, Bingshan et al. (2013) Recurrent tissue-specific mtDNA mutations are common in humans. PLoS Genet 9:e1003929

Showing the most recent 10 out of 13 publications