The overarching goal ofthe Research Design and Analysis Core (RDAC) is to provide OAIC investigators access to statistical services at all stages of the research lifecycle. By establishing a central hub of statistical expertise, the RDAC will ensure smooth delivery of statistical knowledge and rigor across the spectrum of scientific research at the OAIC. This will improve the quality of OAIC research studies, help nurture trainees, facilitate Interdisciplinary research groups, and ultimately enhance research on prediction, characterization, and outcomes of late-life disability, especially in vulnerable populations. The RDAC will promote wider use of state of the art statistical practice, lower barriers of access to basic statistical services to all research groups including trainees, provide access to specialized statistical resources (such as state ofthe art prognostic model development, complex longitudinal and latent class analysis, and causal inference methods), and develop statistical procedures targeted to solving problems in aging research, and more specifically to challenges that commonly arise in research on disability and function. We propose to accomplish this goal through the following specific aims: (1) to establish a central hub of statistical expertise;(2) to participate in the design of new studies and grant applications;(3) to promote adoption of state-of-the art prognostic modeling techniques and statistical methodology in aging research;(4) to provide data analysis services to aging researchers;(5) to collaborate in the preparation of research manuscripts;(6) to build connections between OAIC and quantitative researchers;and (7) to oversee a developmental project on statistical methods and software for validating the prognostic model building process.

Public Health Relevance

Researchers on late-life disability In vulnerable populations are confronted by an array of statistical challenges. By providing resources directly and pro-actively addressing these challenges, the Research Design and Analysis Core will greatly enhance the quality ofthe research by OAIC investigators.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Peralta, Carmen A; McClure, Leslie A; Scherzer, Rebecca et al. (2016) Effect of Intensive Versus Usual Blood Pressure Control on Kidney Function Among Individuals With Prior Lacunar Stroke: A Post Hoc Analysis of the Secondary Prevention of Small Subcortical Strokes (SPS3) Randomized Trial. Circulation 133:584-91
Gardner, Raquel C; Hess, Christopher P; Brus-Ramer, Marcel et al. (2016) Cavum Septum Pellucidum in Retired American Pro-Football Players. J Neurotrauma 33:157-61
Lee, Christopher Thomas; Guzman, David; Ponath, Claudia et al. (2016) Residential patterns in older homeless adults: Results of a cluster analysis. Soc Sci Med 153:131-40
John, Malcolm D; Greene, Meredith; Hessol, Nancy A et al. (2016) Geriatric Assessments and Association With VACS Index Among HIV-Infected Older Adults in San Francisco. J Acquir Immune Defic Syndr 72:534-41
Flatt, Jason D; Williams, Brie A; Barnes, Deborah et al. (2016) Post-traumatic stress disorder symptoms and associated health and social vulnerabilities in older jail inmates. Aging Ment Health :1-7
Samoylova, Mariya L; Covinsky, Kenneth E; Haftek, Marta et al. (2016) Disability in Patients with End-Stage Liver Disease: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study. Liver Transpl :
Barnhart, Caroline; McClymont, Keelan; Smith, Alex K et al. (2016) ""Everyone else gets ice cream here more often than I do--It burns me up""--Perspectives on Diabetes Care from Nursing Home Residents and their Doctors. BMC Geriatr 16:28
Lai, Jennifer C (2016) Defining the threshold for too sick for transplant. Curr Opin Organ Transplant 21:127-32
Pavasini, Rita; Guralnik, Jack; Brown, Justin C et al. (2016) Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis. BMC Med 14:215
Lai, Jennifer C; Volk, Michael L; Strasburg, Debra et al. (2016) Performance-Based Measures Associate With Frailty in Patients With End-Stage Liver Disease. Transplantation 100:2656-2660

Showing the most recent 10 out of 105 publications