The proposed UW CFAR is organized around 6 core units: Administration (including information transfer/publications and research training); clinical and molecular retrovirology; immunology, clinical research; biostatistics and epidemiology (including International AIDS Research and AIDS Registry); and non- human primate research. Two additional core units, behavioral sciences research and radiological imaging research, are envisioned via separate funding in future years. Over 75 faculty staff investigators of the proposed CFAR participate in active or pending research grants directly related to AIDS, HIV, or SIV and many of these also have other active grants in closely related fields such as non-primate retrovirology, molecular/cellular immunology, and other STDs. Ten distinct AIDS related themes have been identified, many involving parallel research in humans and non-human primates. The proposed CFAR would help coordinate this research to ensure efficient use of primates in research most relevant to human infection. Six active and two pending institutional post-doctoral research or clinical training grants at the UW are AIDS related. The process of planning this proposal has helped to coordinate the new allocations of 7450 sq. ft. of lab space to basic research on HIV and SIV. The CFAR would fund alteration, renovation, and equipping of a portion of these labs on the UW campus and at Fred Hutchinson Cancer Research Center. Planning for relocation of the HMC AIDS Clinic and the NIAID ACTU is already funded and underway. The CFAR would fund creation and co-location of a CFAR Clinical Research unit, including clinical and epidemiologic research trainees at the same site as the AIDS clinic and ACTU.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027757-04
Application #
3101065
Study Section
Special Emphasis Panel (SRC (41))
Project Start
1988-09-30
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Fredericksen, Rob J; Mayer, Kenneth H; Gibbons, Laura E et al. (2018) Development and Content Validation of a Patient-Reported Sexual Risk Measure for Use in Primary Care. J Gen Intern Med 33:1661-1668
Wilson, Kate S; Wanje, George; Masese, Linnet et al. (2018) A Prospective Cohort Study of Fertility Desire, Unprotected Sex, and Detectable Viral Load in HIV-Positive Female Sex Workers in Mombasa, Kenya. J Acquir Immune Defic Syndr 78:276-282
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Gómez, Laurén A; Crowell, Claudia S; Njuguna, Irene et al. (2018) Improved Neurodevelopment After Initiation of Antiretroviral Therapy in Human Immunodeficiency Virus-infected Children. Pediatr Infect Dis J 37:916-922
Ikoma, Minako; Gantt, Soren; Casper, Corey et al. (2018) KSHV oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite. PLoS One 13:e0192659
Lohman-Payne, Barbara; Gabriel, Benjamin; Park, Sangshin et al. (2018) HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort. Clin Transl Med 7:26
McGrath, Christine J; Singa, Benson; Langat, Agnes et al. (2018) Non-disclosure to male partners and incomplete PMTCT regimens associated with higher risk of mother-to-child HIV transmission: a national survey in Kenya. AIDS Care 30:765-773
Thomson, Kerry A; Dhanireddy, Shireesha; Andrasik, Michele et al. (2018) Fertility desires and preferences for safer conception strategies among people receiving care for HIV at a publicly-funded clinic in Seattle, WA. AIDS Care 30:121-129
Stone, Mars; Bainbridge, John; Sanchez, Ana M et al. (2018) Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates. J Clin Microbiol 56:

Showing the most recent 10 out of 1275 publications