CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert WCoombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine & Medicine; Co-Director, Tuofu Zhu,M.D., Ph.D., Associate Professor, Department of Laboratory Medicine.SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED.The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational andinterdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection byproviding and developing HIV virology laboratory support and services for CFAR investigators. This purposewill be accomplished by providing virological markers of disease progression and regression andmaintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, toserological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIVshedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virologicallaboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which aremajor themes of the UW CFAR proposal.The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratoryinclude: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664; Al-32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005); HIV-1 shedding,transmission and tropism (AI-38518; R21 pending); Evolution of HIV-1 variants in semen and blood (Al-32885, AI-35539); Virological and host determinants of HIV-1 shedding in semen (DK-49477); Effect offemale genital tract infection on HIV-1 shedding and evolution (HD40540); Effect of mucosal inflammationand HSV on HIV shedding (AI-4798; CFAR/CIPRA programs); Lymphoctye adhesion and HIV activation inthe lung (RO1-HL083481); Mycobacterium infection and host defense (K08-HL03577); Pathogenesis of HIVenv and vaccines (AI-47086; AI-065328; HD-38653); and HIV CNS infection and dementia (R21-MH63647).
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