This application for renewal of the UW/FHCRC CFAR includes the University of Washington, Fred Hutchinson Cancer Research Center, Seattle BioMed, and Seattle Children's Hospital, Foundation and Research Institute, and international partner institutions. Our CFAR has over 560 faculty, pre- and postdoctoral trainees, and research scientists. Matching financial support for our CFAR from partner institutions equals 35% of CFAR Direct Costs. The highly interdisciplinary CFAR membership represents 12 of the 16 UW Schools and Colleges and all five FHCRC Divisions. Annual external HIV/AIDS research, training, and service program funding to our four CFAR partners currently exceeds $362 million, including $160 million for 148 awards from six of seven CFAR co-sponsoring NIH institutes, OAR and the Fogarty Center. This warrants effective coordination and communication by the CFAR to optimize the return on investment. Strategic research priorities for the future are (1) Prevent New HIV Infections;(2) Improve HIV Disease Outcomes;(3) Expand Basic Science Discovery Research;and (4) Reduce HIV-Related Health Disparities. To achieve these aims, our goals are (1) Develop a New Generation of Young Innovative HIV/AIDS Researchers;and (2) Provide infrastructure, resources, and incentives for Sustainable Interdisciplinary Translational Science. Ten proposed Cores (three new or completely restructured) and three new Scientific Working Groups (SWGs) emphasize (1) Clinical, Epidemiology, Health Services, and Health Economics Research;(2) Socio- Behavioral and Prevention Research;and (3) Basic Discovery Research, including Retrovirology, Immunology, and Molecular Profiling/Computational Biology. Each Core has individual-level and population-level components, domestic and international components, and collaborations within and external to our CFAR. For the twenty-sixth year of the UW/FHCRC CFAR, we will continue to be innovative. A multi-stage Strategic planning process led to: (1) Merging current Clinical Research and Clinical Retrovirology Cores to improve efficiency and reduce costs;(2) Replacing the Computational Biology Core with a new Molecular Profiling and Computational Biology Core that synergizes FHCRC and UW strengths;(3) Creating an AIDS-Associated Infections and Malignancies Core from a successful SWG;and (4) Launching three new SWGs to build upon strong UW/FHCRC programs for research on Substance Abuse and HIV/STI;Implementation Science;and Curative Therapies for HIV. Cross-CFAR Cores (Administration, Developmental, Biometrics, and International) will support and interact with every Core. The CFAR will support and provide added value for future local, national and international HIV/AIDS research priorities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027757-26
Application #
8489472
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Program Officer
Namkung, Ann S
Project Start
1997-03-01
Project End
2018-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
26
Fiscal Year
2013
Total Cost
$5,254,390
Indirect Cost
$1,407,185
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Dombrowski, Julia C; Carey, James W; Pitts, Nicole et al. (2016) HIV provider and patient perspectives on the Development of a Health Department ""Data to Care"" Program: a qualitative study. BMC Public Health 16:491
Wang, Kerong; Chen, Wei-Ti; Zhang, Lin et al. (2016) Facilitators of and barriers to HIV self-management: Perspectives of HIV-positive women in China. Appl Nurs Res 32:91-97
Dross, Sandra E; Munson, Paul V; Kim, Se Eun et al. (2016) Kinetics of Myeloid-Derived Suppressor Cell Frequency and Function during Simian Immunodeficiency Virus Infection, Combination Antiretroviral Therapy, and Treatment Interruption. J Immunol :
Yang, Cui; Crane, Heidi M; Cropsey, Karen et al. (2016) Implementation of Computer-delivered Brief Alcohol Intervention in HIV Clinical Settings: Who Agrees to Participate? J Addict Res Ther 7:
Kohler, Pamela K; Tippett Barr, Beth A; Kangʼombe, Anderson et al. (2016) Safety, Feasibility, and Acceptability of the PrePex Device for Adult Male Circumcision in Malawi. J Acquir Immune Defic Syndr 72 Suppl 1:S49-55
Hien, Ha Thuc Ai; Thanh, Tran Tan; Thu, Nguyen Thi Mai et al. (2016) Development and evaluation of a real-time polymerase chain reaction assay for the rapid detection of Talaromyces marneffei MP1 gene in human plasma. Mycoses :
Levine, Molly; Beck, Ingrid; Styrchak, Sheila et al. (2016) Comparison of Matrix-Based and Filter Paper-Based Systems for Transport of Plasma for HIV-1 RNA Quantification and Amplicon Preparation for Genotyping. J Clin Microbiol 54:1899-901
Kerani, Roxanne P; Herbeck, Joshua T; Buskin, Susan E et al. (2016) Evidence of Local HIV Transmission in the African Community of King County, Washington. J Immigr Minor Health :
Wilson, Kate S; Wanje, George; Yuhas, Krista et al. (2016) A Prospective Study of Intimate Partner Violence as a Risk Factor for Detectable Plasma Viral Load in HIV-Positive Women Engaged in Transactional Sex in Mombasa, Kenya. AIDS Behav 20:2065-77
Akullian, Adam N; Mukose, Aggrey; Levine, Gillian A et al. (2016) People living with HIV travel farther to access healthcare: a population-based geographic analysis from rural Uganda. J Int AIDS Soc 19:20171

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