The need for observational HIV clinical research to complement the invaluable information provided by randomized controlled trials has grown tremendously, which is why we established the CFAR Clinical Epidemiology and Health Services Research (CE&HSR) program at the University of Washington (UW) in 1997 and were among the first CFARs in the US to do so. The UW CE&HSR Core pioneered approaches to standardization, content, and integration of clinical HIV data required for HIV/AIDS research and has become a key engine for cohort-based health research locally, nationally, and internationally, which has had tremendous impact on the field and on the clinical care and outcomes of HIV-infected individuals. The UW/FHRC CFAR CE&HSR Core will address the following specific aims:
Aim 1. Facilitate Comparative Effectiveness Research to Improve HIV Disease Outcomes: promote and support HIV/AIDS clinical research comparing the effectiveness of treatment strategies for HIV-infected patients in routine clinical care, including the management of serious HIV-associated chronic diseases, such as cardiovascular, renal, and liver disease with the goal of improving HIV disease outcomes. The Core is forming Chronic Disease Study Groups to develop analysis plans for defining and validating data needed to conduct research in the areas of HIV-related pulmonary and neurological complications, cardiovascular, liver and metabolic diseases, and determining the impact of socio-behavioral conditions and HIV-related disparities on clinical outcomes. We will continue to train junior investigators and recruit investigators from other disciplines who are new to HIV research to collaborate in addressing emerging questions regarding HIV/AIDS.
Aim 2. Expand the UW HIV Information System (UWHIS): provide a wide range of research expertise and a comprehensive source of prospective, longitudinal patient data capturing rapidly changing HIV treatment and outcomes to support innovative interdisciplinary HIV/AIDS research. We will promote collaboration between clinician researchers, epidemiologists, biostatisticians, basic scientists, socio-behavioral and health services researchers using novel approaches to address the most pressing questions concerning HIV/AIDS treatment and prevention.
Aim 3. Facilitate Translational and Basic HIV Research: support translational and basic research aimed at defining the underlying pathogenesis of chronic inflammation in HIV and mechanisms leading to chronic end organ disease by expanding clinical specimens collected on the UW HIV Cohort tracked in the UWHIS linked to patient data and stored in the UW HIV Specimen

Public Health Relevance

One of the primary goals of the Clinical Epidemiology and Health Services Research Core is to provide to support for studies that will improve the clinical care and outcomes for HIV-infected individuals. This is accomplished by providing patients lists for study recruitment, clinical data linked to specimens for translational research, and analysis datasets for observational studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027757-26
Application #
8520677
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
26
Fiscal Year
2013
Total Cost
$186,249
Indirect Cost
$56,047
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Stekler, Joanne D; McKernan, Jennifer; Milne, Ross et al. (2015) Lack of resistance to integrase inhibitors among antiretroviral-naive subjects with primary HIV-1 infection, 2007-2013. Antivir Ther 20:77-80
Mohanraj, Rani; Jeyaseelan, Visalakshi; Kumar, Shuba et al. (2015) Cultural adaptation of the Brief COPE for persons living with HIV/AIDS in southern India. AIDS Behav 19:341-51
Mackelprang, Romel D; Bigham, Abigail W; Celum, Connie et al. (2014) Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans. J Infect Dis 209:1623-7
Gantt, Soren; Cattamanchi, Ashok; Krantz, Elizabeth et al. (2014) Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy. J Clin Virol 60:127-32
Slyker, Jennifer A; Casper, Corey; Tapia, Kenneth et al. (2014) Accelerated suppression of primary Epstein-Barr virus infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy. Clin Infect Dis 58:1333-7
Gerdts, Sarah E; Wagenaar, Bradley H; Micek, Mark A et al. (2014) Linkage to HIV care and antiretroviral therapy by HIV testing service type in Central Mozambique: a retrospective cohort study. J Acquir Immune Defic Syndr 66:e37-44
Liu, Yi; Rao, Ushnal; McClure, Jan et al. (2014) Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds. PLoS One 9:e94240
Puttkammer, Nancy H; Zeliadt, Steven B; Balan, Jean Gabriel et al. (2014) Before and after the earthquake: a case study of attrition from the HIV antiretroviral therapy program in Haiti. Glob Health Action 7:24572
Pantalone, David W; Huh, David; Nelson, Kimberly M et al. (2014) Prospective predictors of unprotected anal intercourse among HIV-seropositive men who have sex with men initiating antiretroviral therapy. AIDS Behav 18:78-87
Wagner, Thor A; McLaughlin, Sherry; Garg, Kavita et al. (2014) HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345:570-3

Showing the most recent 10 out of 552 publications