Cancer is increasingly recognized as an important complication of HIV infection, with -10% of HIV-infected persons expected to develop cancer at some point in their lifetime. For many HIV-associated malignancies (HIVAM), few good strategies for prevention or treatment exist. Seattle has developed an extraordinary community of researchers in both cancer and HIV, and over the last five years the AIDS-Associated Infections and Malignancies (AAlMs) Scientific Working Group has been highly successful in bringing together these research communities to address HIVAM. We now propose to expand the activities of the AAlMs group to become a Core in the UW/FHCRC CFAR, with three Specific Aims: 1) Enable studies of HIVAM through the development and deployment of assays for the molecular detection and quantification of viral oncogens;2) Facilitate the diagnosis of HIVAM, as well as detailed studies of HIVAM pathogenesis, in CFAR-affiliated HIV cohorts through the provision of a suite of molecular and immunohistochemical tumor assays;3) Disseminate data instruments to accurately identify and characterize cancer endpoints among HIV-infected persons participating in CFAR-affiliated research studies. To achieve these goals, we have assembled a group of international experts from the Fred Hutchinson Cancer Research Center and the University of Washington to serve on the Core's Steering Committee, leveraged the highly successful Molecular Diagnostics Laboratories in Seattle and Uganda, expanded core pathology diagnostic services offered by the Hutchinson Center and the Seattle Cancer Care Alliance, and utilized the expertise in data collection of the Statistical Center for HIV/AIDS Research &Prevention.
Cancer is a common complication of HIV infection, and better strategies for cancer prevention and treatment are needed. The AIDS-Associated Infections and Malignancies Core will facilitate innovative research in cancer among persons with HIV infection by offering investigators molecular, diagnostic and data tools to increase the scope, quantity and quality of cancer research in cohorts of HIV-infected individuals.
|Stekler, Joanne D; McKernan, Jennifer; Milne, Ross et al. (2015) Lack of resistance to integrase inhibitors among antiretroviral-naive subjects with primary HIV-1 infection, 2007-2013. Antivir Ther 20:77-80|
|Mohanraj, Rani; Jeyaseelan, Visalakshi; Kumar, Shuba et al. (2015) Cultural adaptation of the Brief COPE for persons living with HIV/AIDS in southern India. AIDS Behav 19:341-51|
|Mackelprang, Romel D; Bigham, Abigail W; Celum, Connie et al. (2014) Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans. J Infect Dis 209:1623-7|
|Gantt, Soren; Cattamanchi, Ashok; Krantz, Elizabeth et al. (2014) Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy. J Clin Virol 60:127-32|
|Slyker, Jennifer A; Casper, Corey; Tapia, Kenneth et al. (2014) Accelerated suppression of primary Epstein-Barr virus infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy. Clin Infect Dis 58:1333-7|
|Gerdts, Sarah E; Wagenaar, Bradley H; Micek, Mark A et al. (2014) Linkage to HIV care and antiretroviral therapy by HIV testing service type in Central Mozambique: a retrospective cohort study. J Acquir Immune Defic Syndr 66:e37-44|
|Liu, Yi; Rao, Ushnal; McClure, Jan et al. (2014) Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds. PLoS One 9:e94240|
|Puttkammer, Nancy H; Zeliadt, Steven B; Balan, Jean Gabriel et al. (2014) Before and after the earthquake: a case study of attrition from the HIV antiretroviral therapy program in Haiti. Glob Health Action 7:24572|
|Pantalone, David W; Huh, David; Nelson, Kimberly M et al. (2014) Prospective predictors of unprotected anal intercourse among HIV-seropositive men who have sex with men initiating antiretroviral therapy. AIDS Behav 18:78-87|
|Wagner, Thor A; McLaughlin, Sherry; Garg, Kavita et al. (2014) HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345:570-3|
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