Clinical investigation of HIV-induced disease requires the ability to study at-risk and HIV-infected human subjects. These clinical studies can span a broad spectrum including "bench to bedside" translational research, epidemiological and behavioral studies and implementation and dissemination science. The Clinical and Population Sciences Core is specifically dedicated to enabling translational research within the UCSF-GIVI CFAR. To achieve this goal, this Core pursues four specific aims including:
Aim 1 : To provide expertise in the clinical and population sciences related to HIV/AIDS research via consultation regarding the conception of research questions, study design, sources of data on human subjects, data management, biostatistical analysis, and interpretation of data;
Aim 2 : To manage unique prospective observational cohorts of HIV-infected subjects in both San Francisco (the SCOPE cohort) and Africa (the Uganda-based UARTO and ISS Clinic Cohorts) that provide basic and translational researches with a diverse array of biological specimens and data from subjects who are well-characterized in terms of epidemiologic, clinical, laboratory and behavioral parameters;
Aim 3 : To offer a platform for the efficient conduct of newly proposed prospective human subjects studies;
Aim 4 : To mentor early stage investigators in the conduct of research involving human subjects. Overall, the Clinical and Population Sciences Core provides multiple researchers with an efficient centralized resource that helps circumvent the substantial cost and time burden inherent in the complexity of human subjects research. Evidence of the utility of the Core's approach in the current funding cycle is evidenced by the fact that 251 users have accessed the core, 19,568 biological specimens have been distributed, and 108 papers have been published by Core users. In this proposed renewal, the Core's overall objectives remain unchanged, however activities and resources in the Core will be refined based on the new research initiatives being launched by UCSF-GIVI CFAR investigators.

Public Health Relevance

Scientific advances towards the prevention or cure of HIV infection requires direct research of human subjects infected with HIV or at risk for infection. However, research with human subjects is costly, time-consuming and subject to ethical constraints. To overcome these barriers, the Clinical and Population Sciences Core provides access to three different HIV-infected cohorts and advises interested investigators on the design and implementation of technically and ethically sound clinical...

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027763-21
Application #
8295381
Study Section
Special Emphasis Panel (ZAI1-RRS-A (J1))
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
21
Fiscal Year
2012
Total Cost
$381,411
Indirect Cost
$80,009
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mmeje, Okeoma; van der Poel, Sheryl; Workneh, Meklit et al. (2015) Achieving pregnancy safely: perspectives on timed vaginal insemination among HIV-serodiscordant couples and health-care providers in Kisumu, Kenya. AIDS Care 27:6-Oct
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Liu, Albert Y; Yang, Qiyun; Huang, Yong et al. (2014) Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP). PLoS One 9:e83736
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