The AIDS Specimen Bank (ASB) Core provides expertly collected and cryopreserved biological specimens, linked to detailed clinical information to enable multidisciplinary research bridging laboratory-based basic science with clinical, behavioral and epidemiological investigations. Successful translational research depends on access to high quality specimens thus great attention much be given to how cells are frozen and whether they remain stable with full functionality during storage. The ASB Core has provided this expertise to the UCSF-GIVI CFAR research community since the Center its establishment in 1987. The ASB Core remains crucial to the CFAR translational research effort and has sought to expand the range of services it provides, keeping pace with the innovative new experimental directions initiated by CFAR investigators. In the current grant cycle, ASB has banked 135,414 biological samples and distributed 157,707 samples to interested investigators. ASB also offers consultation and training to early-career investigators, research staff and other trainees regarding specimen choice and biorepository procedures to ensure that sensitive biological samples are properly handled following distribution and that they are appropriate for the planned laboratory assays. ASB has an outstanding reputation for never having lost a specimen due to freezer malfunction, earthquakes, or power outages. ASB's state of the art inventory system can also quickly locate a single cryovial among the bank's 25 ultra-low and 13 liquid nitrogen freezers. ASB continues to seek new methods to improve specimen viability during cyostorage through changes in processing and freezing. Based on surveys of the needs of UCSF-GIVI-CFAR investigators ASB will expand the type of specimens its processes and stores for basic and translational research. ASB will provide also provide its services to support all CFAR members including those based at either domestic or international sites.

Public Health Relevance

The AIDS Specimen Bank Core is committed to supporting the multidisciplinary research mission of the UCSF-GIVI CFAR by providing expertise in the collection, processing, cryopreservation and distribution of well-characterized biological specimens to interested CFAR investigators. The Core closely monitors specimen quality and is constantly exploring new technologies to improve and extend its services. The Core also provides training to interested individuals including scientists located at international sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027763-21
Application #
8295390
Study Section
Special Emphasis Panel (ZAI1-RRS-A (J1))
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
21
Fiscal Year
2012
Total Cost
$185,674
Indirect Cost
$80,009
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Chew, Glen M; Fujita, Tsuyoshi; Webb, Gabriela M et al. (2016) TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog 12:e1005349
Fernandez, Samantha G; Miranda, Jj L (2016) Bendamustine reactivates latent Epstein-Barr virus. Leuk Lymphoma 57:1208-10
John, Malcolm D; Greene, Meredith; Hessol, Nancy A et al. (2016) Geriatric Assessments and Association With VACS Index Among HIV-Infected Older Adults in San Francisco. J Acquir Immune Defic Syndr 72:534-41
Khoury, Gabriela; Anderson, Jenny L; Fromentin, Rémi et al. (2016) Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy. AIDS 30:1511-20
Sacha, Jonah B; Ndhlovu, Lishomwa C (2016) Strategies to target non-T-cell HIV reservoirs. Curr Opin HIV AIDS 11:376-82
Ramirez, Christina M; Sinclair, Elizabeth; Epling, Lorrie et al. (2016) Immunologic profiles distinguish aviremic HIV-infected adults. AIDS 30:1553-62
Musinguzi, Nicholas; Mocello, Rain A; Boum 2nd, Yap et al. (2016) Duration of Viral Suppression and Risk of Rebound Viremia with First-Line Antiretroviral Therapy in Rural Uganda. AIDS Behav :
Koss, Catherine A; Natureeba, Paul; Kwarisiima, Dalsone et al. (2016) Viral Suppression and Retention in Care up to 5 Years after Initiation of Lifelong ART during Pregnancy (Option B+) in Rural Uganda. J Acquir Immune Defic Syndr :
Shirakawa, Kotaro; Wang, Lan; Man, Na et al. (2016) Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife 5:
Gianella, Sara; Ginocchio, Christine C; Daar, Eric S et al. (2016) Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy. BMC Infect Dis 16:24

Showing the most recent 10 out of 1312 publications