Clinical invesfigafion of HIV-induced disease requires the ability to study at-risk and HIV-infected human subjects. These clinical studies can span a broad spectrum including """"""""bench to bedside"""""""" translafional research, epidemiological and behavioral studies and implementation and dissemination science. The Clinical and Population Sciences Core is specifically dedicated to enabling translational research within the UCSF-GIVI CFAR. To achieve this goal, this Core pursues four specific aims including:
Aim 1 : To provide expertise in the clinical and populafion sciences related to HIV/AIDS research via consultafion regarding the concepfion of research quesfions, study design, sources of data on human subjects, data management, biostatistical analysis, and interpretation of data;
Aim 2 : To manage unique prospective observational cohorts of HIV-infected subjects in both San Francisco (the SCOPE cohort) and Africa (the Uganda-based UARTO and ISS Clinic Cohorts) that provide basic and translational researches with a diverse array of biological specimens and data from subjects who are well-characterized in terms of epidemiologic, clinical, laboratory and behavioral parameters;
Aim 3 : To offer a platform for the efficient conduct of newly proposed prospective human subjects studies;
Aim 4 : To mentor early stage investigators in the conduct of research involving human subjects. Overall, the Clinical and Population Sciences Core provides mulfiple researchers with an efficient centralized resource that helps circumvent the substanfial cost and time burden inherent in the complexity of human subjects research. Evidence of the utility of the Core's approach in the current funding cycle is evidenced by the fact that 251 users have accessed the core, 19,568 biological specimens have been distributed, and 108 papers have been published by Core users. In this proposed renewal, the Core's overall objectives remain unchanged, however activities and resources in the Core will be refined based on the new research inifiatives being launched by UCSF-GIVI CFAR invesfigators. Specifically the SCOPE cohort will be expanded to address new quesfions in HIV.

Public Health Relevance

Scientific advances towards the prevention or cure of HIV infection requires direct research of human subjects infected with HIV or at risk for infection. However, research with human subjects is costly, time-consuming and subject to ethical constraints. To overcome these barriers, the Clinical and Population Sciences Core provides access to three different HIV-infected cohorts and advises interested investigators on the design and implementation of technically and ethically sound clinical...

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027763-23
Application #
8709970
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
23
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Flentje, Annesa; Kober, Kord M; Carrico, Adam W et al. (2018) Minority stress and leukocyte gene expression in sexual minority men living with treated HIV infection. Brain Behav Immun 70:335-345
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Ong, Jason J; Wu, Dan; Huang, Wenting et al. (2018) Pressured HIV testing ""in the name of love"": a mixed methods analysis of pressured HIV testing among men who have sex with men in China. J Int AIDS Soc 21:e25098
Scheer, Susan; Hsu, Ling; Schwarcz, Sandra et al. (2018) Trends in the San Francisco Human Immunodeficiency Virus Epidemic in the ""Getting to Zero"" Era. Clin Infect Dis 66:1027-1034
Kiniry, Brenna E; Li, Shengbin; Ganesh, Anupama et al. (2018) Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol 11:909-920
Ali, Ibraheem; Conrad, Ryan J; Verdin, Eric et al. (2018) Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev 118:1216-1252

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