UAB CFAR Mission: To support UAB and affiliated investigators in the conduct of multidisciplinary, cutting-edge research in the prevention, pathogenesis, therapeutics, clinical care, and psychosocial manifestations of HIV and related disorders in the United States and around the world. The UAB CFAR was established in 1988 as one of the original seven charter centers of a new NIH initiative. From the outset, the UAB CFAR has played a national and international leadership role in basic, translational, and clinical HIV/AIDS research. With seminal research discoveries spanning the gamut from HIV-1 viral dynamics to viral diversity to the zoonotic origins of HIV-1, and with translational therapeutics research leading to first-in-human trials, and ultimately FDA approval, of no fewer than 7 antiretroviral drugs, the UAB CFAR and its members have played an instrumental role in leading HIV/AIDS research efforts on a global scale for twenty years. Remarkably, with the exception of Dr. Eric Hunter who recently left the institution, the core scientific leadership of the UAB CFAR including Drs. Michael S. Saag (Experimental Therapeutics and current CFAR Director), Beatrice H. Hahn (Virus Discovery and current CFAR Co-Director), George M. Shaw (Viral Pathogenesis and current CFAR Associate Director), and Casey Morrow (Molecular Virology and current CFAR Associate Director and Developmental Core Leader), has remained intact since the inception of the UAB CFAR. This leadership group has spearheaded and nurtured a major HIV/AIDS research agenda for over twenty years and has fostered the recruitment and development of a new generation of HIV/AIDS investigators at UAB. What will become evident in this revised application is that the UAB CFAR continues to provide scientific leadership, programmatic coordination, essential research support services training in scientific methodologies, effective communication, targeted faculty recruitment, and linkages between investigators working in widely diverse areas of research in a manner that makes UAB HIV/AIDS research important today as it has been for the past twenty years

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-SV-A)
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University of Alabama Birmingham
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Bateman, Allen C; Chibwesha, Carla J; Parham, Groesbeck P (2015) Minimizing verification bias in cervical cancer screening of HIV-infected women. Int J Gynaecol Obstet 128:269-70
Miller, Michelle M; Akaronu, Nnenna; Thompson, Elizabeth M et al. (2015) Modulating DNA methylation in activated CD8+ T cells inhibits regulatory T cell-induced binding of Foxp3 to the CD8+ T Cell IL-2 promoter. J Immunol 194:990-8
Li, Jun; Hsu, Hui-Chen; Ding, Yana et al. (2014) Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis. Arthritis Rheumatol 66:2368-79
Mugavero, Michael J; Westfall, Andrew O; Cole, Stephen R et al. (2014) Beyond core indicators of retention in HIV care: missed clinic visits are independently associated with all-cause mortality. Clin Infect Dis 59:1471-9
Stevenson, Catherine; de la Rosa, Gonzalo; Anderson, Christopher S et al. (2014) Essential role of Elmo1 in Dock2-dependent lymphocyte migration. J Immunol 192:6062-70
Yuan, Furong; Yosef, Nejla; Lakshmana Reddy, Chetan et al. (2014) CCR2 gene deletion and pharmacologic blockade ameliorate a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. PLoS One 9:e90463
Parker, Ivana Kennedy; Roberts, Ladeidra Monet; Hansen, Laura et al. (2014) Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Ann Biomed Eng 42:1185-94
Huijbregts, Richard P H; Michel, Katherine G; Hel, Zdenek (2014) Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs. Contraception 90:123-9
Sarzotti-Kelsoe, Marcella; Daniell, Xiaoju; Todd, Christopher A et al. (2014) Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. J Immunol Methods 409:147-60
Li, Hao; Hsu, Hui-Chen; Wu, Qi et al. (2014) IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and ROR?t. Nat Commun 5:4259

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