UAB CFAR Mission: To support UAB and affiliated investigators in the conduct of multidisciplinary, cutting-edge research in the prevention, pathogenesis, therapeutics, clinical care, and psychosocial manifestations of HIV and related disorders in the United States and around the world. The UAB CFAR was established in 1988 as one of the original seven charter centers of a new NIH initiative. From the outset, the UAB CFAR has played a national and international leadership role in basic, translational, and clinical HIV/AIDS research. With seminal research discoveries spanning the gamut from HIV-1 viral dynamics to viral diversity to the zoonotic origins of HIV-1, and with translational therapeutics research leading to first-in-human trials, and ultimately FDA approval, of no fewer than 7 antiretroviral drugs, the UAB CFAR and its members have played an instrumental role in leading HIV/AIDS research efforts on a global scale for twenty years. Remarkably, with the exception of Dr. Eric Hunter who recently left the institution, the core scientific leadership of the UAB CFAR including Drs. Michael S. Saag (Experimental Therapeutics and current CFAR Director), Beatrice H. Hahn (Virus Discovery and current CFAR Co-Director), George M. Shaw (Viral Pathogenesis and current CFAR Associate Director), and Casey Morrow (Molecular Virology and current CFAR Associate Director and Developmental Core Leader), has remained intact since the inception of the UAB CFAR. This leadership group has spearheaded and nurtured a major HIV/AIDS research agenda for over twenty years and has fostered the recruitment and development of a new generation of HIV/AIDS investigators at UAB. What will become evident in this revised application is that the UAB CFAR continues to provide scientific leadership, programmatic coordination, essential research support services training in scientific methodologies, effective communication, targeted faculty recruitment, and linkages between investigators working in widely diverse areas of research in a manner that makes UAB HIV/AIDS research important today as it has been for the past twenty years

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-SV-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Salazar-Gonzalez, Jesus F; Salazar, Maria G; Tully, Damien C et al. (2016) Use of Dried Blood Spots to Elucidate Full-Length Transmitted/Founder HIV-1 Genomes. Pathog Immun 1:129-153
Abedini-Nassab, Roozbeh; Joh, Daniel Y; Van Heest, Melissa et al. (2016) Magnetophoretic Conductors and Diodes in a 3D Magnetic Field. Adv Funct Mater 26:4026-4034
Dalecki, Alex G; Malalasekera, Aruni P; Schaaf, Kaitlyn et al. (2016) Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity. Metallomics 8:412-21
Pettit, April C; Mendes, Adell; Jenkins, Cathy et al. (2016) Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment. J Acquir Immune Defic Syndr 72:572-8
Friedman, Gregory K; Moore, Blake P; Nan, Li et al. (2016) Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses. Neuro Oncol 18:227-35
Demark-Wahnefried, Wendy; Nix, Jeffery W; Hunter, Gary R et al. (2016) Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for BMC Cancer 16:61
Merlin, Jessica S; Tamhane, Ashutosh; Starrels, Joanna L et al. (2016) Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV. AIDS Behav 20:687-98
Khan, Shahzada; Woodruff, Erik M; Trapecar, Martin et al. (2016) Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. J Exp Med 213:2913-2929
Kumar, Ashish; Zhang, Jennifer; Tallaksen-Greene, Sara et al. (2016) Allelic series of Huntington's disease knock-in mice reveals expression discorrelates. Hum Mol Genet 25:1619-36
Qin, Hongwei; Buckley, Jessica A; Li, Xinru et al. (2016) Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration. J Neurosci 36:5144-59

Showing the most recent 10 out of 784 publications