Abstract

Mission: Apply social and behavioral science methods to the interdisciplinary investigation of HIV/AIDS to improve its understanding, prevention, and treatment and improve the quality of life of persons living with HIV/AIDS.
Aim 1. Increase the utility and efficiency of HIV/AIDS research by providing behavioral science research services and methods to CFAR Investigators (and other users).
Aim 2. Establish research partnerships between CFAR Investigators (and other users) and behavioral scientists to increase interdisciplinary HIV/AIDS.
Aim 3. Offer training and advocacy to students, new investigators, trainees, agencies, community, and consumers to increase behavioral science research knowledge, skills, and human subject protection in HIV/AIDS research. Added-value: The Core supported 202 users in 2007 compared to 39 users in 2006 - where 42% of users were CFAR investigators in 2007 versus 12.5% in 2006. Scientific discoveries and public health relevance include: Behavioral/epidemiological research involving discordant couples in Zambia led to important insights into HIV transmission;research on injection drug users in China led to HIV prevention policy changes;effective sexual risk reduction strategies among adolescents have been developed to prevent future HIV transmission;motivational readiness guide effective sexual risk reduction interventions;first behavioral treatment for injection drug use and HIV risk reduction effectively transported to Ukraine;and unique barriers to HIV/AIDS treatment were discovered among rural African American women.

Public Health Relevance

include: Behavioral/epidemiological research involving discordant couples in Zambia led to important insights into HIV transmission;research on injection drug users in China led to HIV prevention policy changes;effective sexual risk reduction strategies among adolescents have been developed to prevent future HIV transmission;motivational readiness guide effective sexual risk reduction interventions;first behavioral treatment for injection drug use and HIV risk reduction effectively transported to Ukraine;and unique barriers to HIV/AIDS treatment were discovered among rural African American women.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027767-25
Application #
8495872
Study Section
Special Emphasis Panel (ZAI1-SV-A)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
25
Fiscal Year
2013
Total Cost
$147,026
Indirect Cost
$46,667

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Smith, Samuel R; Schaaf, Kaitlyn; Rajabalee, Nusrah et al. (2018) The phosphatase PPM1A controls monocyte-to-macrophage differentiation. Sci Rep 8:902
Wang, Yong; Schafer, Cara C; Hough, Kenneth P et al. (2018) Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol 201:278-295
Jones, Robert B; Dorsett, Kaitlyn A; Hjelmeland, Anita B et al. (2018) The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling. J Biol Chem 293:5659-5667
Dionne-Odom, Jodie; Westfall, Andrew O; Van Der Pol, Barbara et al. (2018) Sexually Transmitted Infection Prevalence in Women With HIV: Is There a Role for Targeted Screening? Sex Transm Dis 45:762-769
Frugé, Andrew D; Van der Pol, William; Rogers, Laura Q et al. (2018) Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet :
Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R et al. (2018) Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework. Am J Epidemiol 187:316-325
Crenshaw, Brennetta J; Gu, Linlin; Sims, Brian et al. (2018) Exosome Biogenesis and Biological Function in Response to Viral Infections. Open Virol J 12:134-148
Trapecar, Martin; Khan, Shahzada; Cohn, Benjamin L et al. (2018) B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol 11:1158-1167
Sahay, Bikash; Bashant, Kathleen; Nelson, Nicole L J et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun 86:
Verma, Richa; Sahu, Rajnish; Dixit, Saurabh et al. (2018) The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic Front Immunol 9:2369

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