Mission: Apply social and behavioral science methods to the interdisciplinary investigation of HIV/AIDS to improve its understanding, prevention, and treatment and improve the quality of life of persons living with HIV/AIDS.
Aim 1. Increase the utility and efficiency of HIV/AIDS research by providing behavioral science research services and methods to CFAR Investigators (and other users).
Aim 2. Establish research partnerships between CFAR Investigators (and other users) and behavioral scientists to increase interdisciplinary HIV/AIDS.
Aim 3. Offer training and advocacy to students, new investigators, trainees, agencies, community, and consumers to increase behavioral science research knowledge, skills, and human subject protection in HIV/AIDS research. Added-value: The Core supported 202 users in 2007 compared to 39 users in 2006 - where 42% of users were CFAR investigators in 2007 versus 12.5% in 2006. Scientific discoveries and public health relevance include: Behavioral/epidemiological research involving discordant couples in Zambia led to important insights into HIV transmission;research on injection drug users in China led to HIV prevention policy changes;effective sexual risk reduction strategies among adolescents have been developed to prevent future HIV transmission;motivational readiness guide effective sexual risk reduction interventions;first behavioral treatment for injection drug use and HIV risk reduction effectively transported to Ukraine;and unique barriers to HIV/AIDS treatment were discovered among rural African American women.

Public Health Relevance

include: Behavioral/epidemiological research involving discordant couples in Zambia led to important insights into HIV transmission;research on injection drug users in China led to HIV prevention policy changes;effective sexual risk reduction strategies among adolescents have been developed to prevent future HIV transmission;motivational readiness guide effective sexual risk reduction interventions;first behavioral treatment for injection drug use and HIV risk reduction effectively transported to Ukraine;and unique barriers to HIV/AIDS treatment were discovered among rural African American women.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027767-25
Application #
8495872
Study Section
Special Emphasis Panel (ZAI1-SV-A)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
25
Fiscal Year
2013
Total Cost
$147,026
Indirect Cost
$46,667
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Bateman, Allen C; Chibwesha, Carla J; Parham, Groesbeck P (2015) Minimizing verification bias in cervical cancer screening of HIV-infected women. Int J Gynaecol Obstet 128:269-70
Miller, Michelle M; Akaronu, Nnenna; Thompson, Elizabeth M et al. (2015) Modulating DNA methylation in activated CD8+ T cells inhibits regulatory T cell-induced binding of Foxp3 to the CD8+ T Cell IL-2 promoter. J Immunol 194:990-8
Li, Jun; Hsu, Hui-Chen; Ding, Yana et al. (2014) Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis. Arthritis Rheumatol 66:2368-79
Mugavero, Michael J; Westfall, Andrew O; Cole, Stephen R et al. (2014) Beyond core indicators of retention in HIV care: missed clinic visits are independently associated with all-cause mortality. Clin Infect Dis 59:1471-9
Stevenson, Catherine; de la Rosa, Gonzalo; Anderson, Christopher S et al. (2014) Essential role of Elmo1 in Dock2-dependent lymphocyte migration. J Immunol 192:6062-70
Yuan, Furong; Yosef, Nejla; Lakshmana Reddy, Chetan et al. (2014) CCR2 gene deletion and pharmacologic blockade ameliorate a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. PLoS One 9:e90463
Parker, Ivana Kennedy; Roberts, Ladeidra Monet; Hansen, Laura et al. (2014) Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Ann Biomed Eng 42:1185-94
Huijbregts, Richard P H; Michel, Katherine G; Hel, Zdenek (2014) Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs. Contraception 90:123-9
Sarzotti-Kelsoe, Marcella; Daniell, Xiaoju; Todd, Christopher A et al. (2014) Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. J Immunol Methods 409:147-60
Li, Hao; Hsu, Hui-Chen; Wu, Qi et al. (2014) IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and ROR?t. Nat Commun 5:4259

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