Core 8: Developmental In order for scientific innovation in HIV research to continue to move forward, we must support our youngest and brightest scientists. The Developmental Core will support young scientists and innovation by serving as a mentoring, innovation and research integration platform that serves the CFAR members. Guided by the NIH HIV/AIDS Research initiatives implementation ofthe CFAR vision has been and remains key to uphold the dynamic and vibrant research environment that has made the UAB CFAR one ofthe most prolific contributors to HIV research in the last 25 years. This is achieved by (i) a strong emphasis on mentoring of junior investigators, (ii) the initiation of targeted research collaborations through pilot awards and (iii), in conjunction with UAB Departments, the recruitment of faculty that support the vision of the CFAR. The following aims of this application will achieve these goals:
Aim 1. Mentoring young UAB CFAR faculty members to compete and cope with the rigors of academic research The core provides targeted mentoring to junior faculty via faculty development programs, linkage with IRGs and assistance with grant writing and review.
Aim 2. Administration of the CFAR Developmental Grant Program We will continue to administer the highly successful CFAR Developmental Grant Program. As this program lends itself to steer ongoing HIV research efforts at UAB, the program will be aligned with the NIH HIV/AIDS Research initiatives and place an emphasis on young investigators.
Aim 3. Use of interdisciplinary research groups (IRGs) as a funding and mentoring mechanism We have initiated the creation of IRGs that would focus on the most pertinent areas of HIV research through a new funding mechanism and will continue to create up to two IRGs per year. We will evaluate the productivity of the IRG and assist in the conversion of the most successful IRGs into Scientific Working Groups (SWGs), thereby creating new programmatic areas within the UAB CFAR that operationalize its Scientific Agenda.
Aim 4. Recruitment of investigators who fit the CFAR Strategic Plan As in the past, we will work with different UAB Departments to jointly recruit faculty who will meet the strategic needs of both organizations. To this end, we will leverage existing University resources to assist with the recruitment of top quality investigators.
The Developmental Core (Core B) supports scientific innovation in HIV research by assisting collaboration and research among its CFAR members. Core B completes these goals by assisting interdisciplinary research groups (IRGs) comprised of investigators focused on scientific areas of mutual benefit, by prioritizing support of young CFAR investigators, and by recruiting faculty who fill the scientific needs of the UAB CFAR.
|Abedini-Nassab, Roozbeh; Joh, Daniel Y; Van Heest, Melissa et al. (2016) Magnetophoretic Conductors and Diodes in a 3D Magnetic Field. Adv Funct Mater 26:4026-4034|
|Salazar-Gonzalez, Jesus F; Salazar, Maria G; Tully, Damien C et al. (2016) Use of Dried Blood Spots to Elucidate Full-Length Transmitted/Founder HIV-1 Genomes. Pathog Immun 1:129-153|
|Pettit, April C; Mendes, Adell; Jenkins, Cathy et al. (2016) Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment. J Acquir Immune Defic Syndr 72:572-8|
|Dalecki, Alex G; Malalasekera, Aruni P; Schaaf, Kaitlyn et al. (2016) Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity. Metallomics 8:412-21|
|Demark-Wahnefried, Wendy; Nix, Jeffery W; Hunter, Gary R et al. (2016) Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for BMC Cancer 16:61|
|Friedman, Gregory K; Moore, Blake P; Nan, Li et al. (2016) Pediatric medulloblastoma xenografts including molecular subgroup 3 and CD133+ and CD15+ cells are sensitive to killing by oncolytic herpes simplex viruses. Neuro Oncol 18:227-35|
|Merlin, Jessica S; Tamhane, Ashutosh; Starrels, Joanna L et al. (2016) Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV. AIDS Behav 20:687-98|
|Khan, Shahzada; Woodruff, Erik M; Trapecar, Martin et al. (2016) Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. J Exp Med 213:2913-2929|
|Kumar, Ashish; Zhang, Jennifer; Tallaksen-Greene, Sara et al. (2016) Allelic series of Huntington's disease knock-in mice reveals expression discorrelates. Hum Mol Genet 25:1619-36|
|Qin, Hongwei; Buckley, Jessica A; Li, Xinru et al. (2016) Inhibition of the JAK/STAT Pathway Protects Against Î±-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration. J Neurosci 36:5144-59|
Showing the most recent 10 out of 784 publications