Core 8: Developmental In order for scientific innovation in HIV research to continue to move forward, we must support our youngest and brightest scientists. The Developmental Core will support young scientists and innovation by serving as a mentoring, innovation and research integration platform that serves the CFAR members. Guided by the NIH HIV/AIDS Research initiatives implementation ofthe CFAR vision has been and remains key to uphold the dynamic and vibrant research environment that has made the UAB CFAR one ofthe most prolific contributors to HIV research in the last 25 years. This is achieved by (i) a strong emphasis on mentoring of junior investigators, (ii) the initiation of targeted research collaborations through pilot awards and (iii), in conjunction with UAB Departments, the recruitment of faculty that support the vision of the CFAR. The following aims of this application will achieve these goals:
Aim 1. Mentoring young UAB CFAR faculty members to compete and cope with the rigors of academic research The core provides targeted mentoring to junior faculty via faculty development programs, linkage with IRGs and assistance with grant writing and review.
Aim 2. Administration of the CFAR Developmental Grant Program We will continue to administer the highly successful CFAR Developmental Grant Program. As this program lends itself to steer ongoing HIV research efforts at UAB, the program will be aligned with the NIH HIV/AIDS Research initiatives and place an emphasis on young investigators.
Aim 3. Use of interdisciplinary research groups (IRGs) as a funding and mentoring mechanism We have initiated the creation of IRGs that would focus on the most pertinent areas of HIV research through a new funding mechanism and will continue to create up to two IRGs per year. We will evaluate the productivity of the IRG and assist in the conversion of the most successful IRGs into Scientific Working Groups (SWGs), thereby creating new programmatic areas within the UAB CFAR that operationalize its Scientific Agenda.
Aim 4. Recruitment of investigators who fit the CFAR Strategic Plan As in the past, we will work with different UAB Departments to jointly recruit faculty who will meet the strategic needs of both organizations. To this end, we will leverage existing University resources to assist with the recruitment of top quality investigators.

Public Health Relevance

The Developmental Core (Core B) supports scientific innovation in HIV research by assisting collaboration and research among its CFAR members. Core B completes these goals by assisting interdisciplinary research groups (IRGs) comprised of investigators focused on scientific areas of mutual benefit, by prioritizing support of young CFAR investigators, and by recruiting faculty who fill the scientific needs of the UAB CFAR.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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University of Alabama Birmingham
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Kumar, Ranjit; Yi, Nengjun; Zhi, Degui et al. (2017) Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile. NPJ Biofilms Microbiomes 3:12
Rodriguez-Garcia, M; Shen, Z; Barr, F D et al. (2017) Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal Immunol 10:531-544
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390
Willig, Amanda L; Kramer, Philip A; Chacko, Balu K et al. (2017) Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women. Redox Biol 12:648-656
Zhang, Yong; Kwon, Dongjin; Pohl, Kilian M (2017) Computing group cardinality constraint solutions for logistic regression problems. Med Image Anal 35:58-69
Khass, Mohamed; Schelonka, Robert L; Liu, Cun Ren et al. (2017) Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ?D-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3. Autoimmunity 50:42-51
Crane, Heidi M; Nance, Robin M; Merrill, Joseph O et al. (2017) Not all non-drinkers with HIV are equal: demographic and clinical comparisons among current non-drinkers with and without a history of prior alcohol use disorders. AIDS Care 29:177-184
Saag, Michael S; Westfall, Andrew O; Cole, Stephen R et al. (2017) Brief Report: Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012. J Acquir Immune Defic Syndr 74:60-64
Robinson, Tanya O; Zhang, Mingce; Ochsenbauer, Christina et al. (2017) CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages. Virology 504:79-87
Zent, Clive S; Elliott, Michael R (2017) Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity. FEBS J 284:1021-1039

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