Core D: Biostatistics &Analysis The Biostatistics and Analysis Core will serve a critical role for the other CFAR Cores with three major areas of focus: 1) Biostatistics including laboratory science, phase 1, II, 111, and IV research;2) Health services research;3) Clinical and population (community) based epidemiological research.
The specific aims encompass the traditional role for a Biostatics and Analysis Core along with our expanding roles in the enhanced focus on clinical outcomes research and community outcomes research. Such leveraging of resources and synergy with other CFAR Cores will contribute to substantial growth in HIV infection research, accomplished through the following specific aims: Provide advice on conceptualization, design, logistics, and conduct analyses required for the specific aims of projects as requested by collaborators from the CFAR membership's individuals with an expanded emphasis on population/'community based behavioral research, outcomes research, and health care economics, especially in conjunction with Core J, the Behavioral and Community Science Core. Work with our data management colleagues in the Clinical Core C to provide expertise in data analyses for the research projects consistent with the CFAR priorities. Collaborate with investigators in the outputs and productivity ofthe CFAR through: interpretation of analyses and writing of manuscripts conducted in collaboration with the CFAR;Collaborate with project investigators to interpret new findings in the literature, evaluate their statistical bases, and determine whether such findings merit any alterations of the scientific course of the CFAR;Assist with the preparation of project reports and presentations;Assist in scientific review of projects, resource management and integrative datasets using distributed processing and facilitated data transfer;Contribute relevant statistical and methodological developments to the scientific community via publication and presentation. Assist in training efforts by providing and participating in seminars, small group discussion and mentoring junior investigators where appropriate.
In light of groundbreaking translational research to develop effective interventions for HIV infection in the modern era, numerous analytical challenges and opportunities exist ranging from genetics and basic science discoveries to the design of population based clinical trials, community intervention research and epidemiological studies. Working with the other Cores and anticipating the growth and development of new HIV initiatives, Core D has reconfigured its investigative team to meet to these challenges.
|Bateman, Allen C; Chibwesha, Carla J; Parham, Groesbeck P (2015) Minimizing verification bias in cervical cancer screening of HIV-infected women. Int J Gynaecol Obstet 128:269-70|
|Miller, Michelle M; Akaronu, Nnenna; Thompson, Elizabeth M et al. (2015) Modulating DNA methylation in activated CD8+ T cells inhibits regulatory T cell-induced binding of Foxp3 to the CD8+ T Cell IL-2 promoter. J Immunol 194:990-8|
|Li, Jun; Hsu, Hui-Chen; Ding, Yana et al. (2014) Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis. Arthritis Rheumatol 66:2368-79|
|Mugavero, Michael J; Westfall, Andrew O; Cole, Stephen R et al. (2014) Beyond core indicators of retention in HIV care: missed clinic visits are independently associated with all-cause mortality. Clin Infect Dis 59:1471-9|
|Stevenson, Catherine; de la Rosa, Gonzalo; Anderson, Christopher S et al. (2014) Essential role of Elmo1 in Dock2-dependent lymphocyte migration. J Immunol 192:6062-70|
|Yuan, Furong; Yosef, Nejla; Lakshmana Reddy, Chetan et al. (2014) CCR2 gene deletion and pharmacologic blockade ameliorate a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome. PLoS One 9:e90463|
|Parker, Ivana Kennedy; Roberts, Ladeidra Monet; Hansen, Laura et al. (2014) Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Ann Biomed Eng 42:1185-94|
|Huijbregts, Richard P H; Michel, Katherine G; Hel, Zdenek (2014) Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs. Contraception 90:123-9|
|Sarzotti-Kelsoe, Marcella; Daniell, Xiaoju; Todd, Christopher A et al. (2014) Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. J Immunol Methods 409:147-60|
|Li, Hao; Hsu, Hui-Chen; Wu, Qi et al. (2014) IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and ROR?t. Nat Commun 5:4259|
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