Since 1989 the mission of the Virology Core has evolved around two primary activities: (i) the provision of campus-wide laboratory infrastructure for BSL2+ research and (ii) the provision of services that facilitate the research adapted to the needs of our CFAR members. The Virology Core provides access for CFAR members to a fully equipped, laboratory infrastructure for BSL2+ research. Provision of access to this infrastructure starts with initial biosafety training and training in fundamental HIV methods. As CFAR members gain access to the BSL2+ facilities, the Virology Core monitors ongoing operation to assure biological safety compliance as mandated by NIH guidelines and UAB Biosafety regulations. Optimal operation is assured by continuous maintenance activities, which includes equipment and facility maintenance.
The specific aims of the Virology Core are as follows:
Aim 1 : Provision of access to state-of-the-art BSL2+ laboratory facilities. ? Provide and maintain BSL2+ laboratory infrastructure. ? Provide training in BSL2+ laboratory containment and personnel protection safety practices in accordance with HHS/CDC laboratory policies and practices for working safely with HIV. ? Provide training for the use of all laboratory equipment ensures safe and effective research activities within the BSL2+ laboratories. ? Monitoring ongoing operation to ensure compliance with biosafety assurance procedures.
Aim 2 : Provision of training for HIV-related research methods and assays developed at UAB. ? Provide training and consultation for the application of virologic methods, techniques and assays. ? Provide defined HIV/AIDS research reagents developed by UAB CFAR investigators.
Aim 3 : On-demand services for molecular cloning and protein expression/purification. ? Provide expertise and services for molecular cloning and protein expression. ? Provide convenient on-site access to commercially available research supplies Around this framework, and through execution of the specific aims by a dedicated professional staff, the Virology Core serves as an """"""""academic hub"""""""", facilitating discovery, stimulating interdisciplinary research, fostering new research opportunities and promoting collaborations and research directions. Our forward looking focus will strengthen and extend Virology Core services that represent high priority opportunities as they align with both CFAR investigator's scientific needs and the National HIV/AIDS Research Strategy.
The UAB CFAR is an academic leader in the global fight against HIV/AIDS. The Scientific Strategy of the UAB CFAR includes coordination of interdisciplinary research projects and programmatic initiatives. Through centralization of important virologic research resources and associated services, the Virology Core enhances the effectiveness and productivity of a large number of HIV/AIDS researchers within the UAB CFAR.
|Kumar, Ranjit; Yi, Nengjun; Zhi, Degui et al. (2017) Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile. NPJ Biofilms Microbiomes 3:12|
|Rodriguez-Garcia, M; Shen, Z; Barr, F D et al. (2017) Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal Immunol 10:531-544|
|Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390|
|Willig, Amanda L; Kramer, Philip A; Chacko, Balu K et al. (2017) Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women. Redox Biol 12:648-656|
|Zhang, Yong; Kwon, Dongjin; Pohl, Kilian M (2017) Computing group cardinality constraint solutions for logistic regression problems. Med Image Anal 35:58-69|
|Khass, Mohamed; Schelonka, Robert L; Liu, Cun Ren et al. (2017) Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ?D-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3. Autoimmunity 50:42-51|
|Crane, Heidi M; Nance, Robin M; Merrill, Joseph O et al. (2017) Not all non-drinkers with HIV are equal: demographic and clinical comparisons among current non-drinkers with and without a history of prior alcohol use disorders. AIDS Care 29:177-184|
|Robinson, Tanya O; Zhang, Mingce; Ochsenbauer, Christina et al. (2017) CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages. Virology 504:79-87|
|Saag, Michael S; Westfall, Andrew O; Cole, Stephen R et al. (2017) Brief Report: Factors Associated With the Selection of Initial Antiretroviral Therapy From 2009 to 2012. J Acquir Immune Defic Syndr 74:60-64|
|Pham, Thieng; Perry, Jacob L; Dosey, Timothy L et al. (2017) The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel. Sci Rep 7:43487|
Showing the most recent 10 out of 872 publications