The main intent of the UCLA CFAR Mucosal Immunology Core Laboratory (MICL) is to serve as an accessible and readily available resource for investigators seeking access to clinically-relevant human samples. The MICL offers a stream-lined process to foster multi-disciplinary interactions for further advances in HIV/AIDS, bridging basic, translational and clinical investigators in the area of HIV-related pathogenesis, treatment strategies and vaccine development. Especially for investigators without direct access to their own patient populations, the MICL provides Users with a coordinated, time-efficient and quality-enforced approach to acquire well-characterized human gastrointestinal (and other) mucosal tissue using our Core/MICL-specific. IRB-approved consent form to acquire samples, a unique MICL-based IRB-approved clinical trial registry for subject recruitment and an IRB-approved tissue bank for pilot studies starting with archived samples. To date, these projects have included acquiring human tissue/fluid/blood samples in pilot (and fully funded) studies of gene/stem cell therapy, nano-medicine approaches, mucosal immunization/tolerance, assessments of increased senescence in HIV-infected, impact of drugs of abuse, viral resistance and body compartmentalization as relates to virus, cells and target drugs. The MICL offers access to (i) a smoothly functioning small clinical trials unit with proven expertise in clinical management, subject recruitment and endoscopic procedures, (ii) a laboratory with a reputation of developing/optimizing novel mucosal assays and (iii) the ability to gain consultative input for protocols/grant applications so they are more firmly grounded in mucosal assessments and feasible, testable endpoints for pilot studies. The MICL assists Users with patient selection, tissue procurement, sample processing, and assistance in institutional review board submissions, refinements in hypothesis testing, detecting changes in the local versus systemic immune response and evaluating treatment responses at the tissue level.

Public Health Relevance

The MICL offers a critical, centralized, cost-effective and efficient resource for investigators seeking tissue/fluids from sexually-exposed mucosae for novel research efforts. These efforts are essential in better understanding HIV mucosal immunopathogenesis (prevention, therapeutics, eradication). With the recent paradigm shift with focus on tissue-impact of HIV, integrated efforts between bedside and bench can complement each other in far more constructive and interactive ways than has been evidenced in the past.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI028697-24
Application #
8520708
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
Project End
Budget Start
2013-03-05
Budget End
2014-02-28
Support Year
24
Fiscal Year
2013
Total Cost
$176,373
Indirect Cost
$35,373
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Das, Aritra; Li, Jianjun; Zhong, Fei et al. (2015) Factors associated with HIV and syphilis co-infection among men who have sex with men in seven Chinese cities. Int J STD AIDS 26:145-55
Shin, Sanghyuk S; Modongo, Chawangwa; Ncube, Ronald et al. (2015) Advanced immune suppression is associated with increased prevalence of mixed-strain Mycobacterium tuberculosis infections among persons at high risk for drug-resistant tuberculosis in Botswana. J Infect Dis 211:347-51
Lee, Sung-Jae; Li, Li; Lin, Chunqing et al. (2015) Challenges facing HIV-positive persons who use drugs and their families in Vietnam. AIDS Care 27:283-7
Holloway, Ian W; Padilla, Mark B; Willner, Lauren et al. (2015) Effects of minority stress processes on the mental health of Latino men who have sex with men and women: a qualitative study. Arch Sex Behav 44:2087-97
Epeldegui, Marta; Blom, Bianca; Uittenbogaart, Christel H (2015) BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells. Eur J Immunol 45:728-37
le Roux, Ingrid M; Rotheram-Borus, Mary Jane; Stein, Judith et al. (2014) The impact of paraprofessional home visitors on infants' growth and health at 18 months. Vulnerable Child Youth Stud 9:291-304
Martin, N T; Nakamura, K; Paila, U et al. (2014) Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks. Cell Death Dis 5:e1130
Preza, Gloria C; Tanner, Karen; Elliott, Julie et al. (2014) Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses 30:241-9
Remenyi, Roland; Qi, Hangfei; Su, Sheng-Yao et al. (2014) A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. MBio 5:e01469-14
Sullivan, Sheena G; Wu, Zunyou; Cao, Xiaobin et al. (2014) Continued drug use during methadone treatment in China: a retrospective analysis of 19,026 service users. J Subst Abuse Treat 47:86-92

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