CORE L: Clinical Research Facilitation Core. The UCLA CFAR Clinical Research Facilitation Core (Core L) provides support for investigators and their staff who are engaged in research involving human subjects with an overall goal to reduce the time between project funding and the initiation and completion of the research. The core has 2 specific aims: 1) To assist investigators with the regulatory approval aspects of biomedical, behavioral and basic translational patient-oriented research in HIV;2) To establish and maintain a continually-updated research participants'registry that will assist investigators with identifying and enrolling subjects into patient-oriented HIV research at UCLA. This core has created a streamlined process for IRB and other regulatory filing and established a v/ay to identify and contact potential research subjects, which reduces costs and the time needed to receive various institutional regulatory approvals and to identify potential subjects for their research. In addition new clinical and translational faculty as well as fellows and postdoctoral students receive training from this core in human subjects regulatory requirements, in proper IRB and other required submissions and how best to recruit for subjects from the diverse and often hard-to-reach populations of HIV-infected and at-risk individuals in the greater LA community. The core provides UCLA investigators, research trainees and staff access to resources that would otherwise not be available or which may be unaffordable to help expedite their research. The UCLA CFAR Clinical Research Facilitation Core also provides valuable recruitment and enrollment tools which help both existing and new faculty expedite their research and which serves as an attractive value added resource for the recruitment and retention of faculty working in HIV at UCLA. To accomplish these aims the Clinical Research Facilitation Core maintains a Regulatory Support arm, and within the last year, has designed and initiated the Research Study Volunteer Project (RSVP) arm, each of which provides services to UCLA CFAR investigators and trainees involved in HIV research who choose to avail themselves of these services. The RSVP program, initiated in late 2011, is in its subject recruitment and implementation phase. We intend to expand and make it more widely available with this competitive renewal.

Public Health Relevance

The CORE L Regulatory Support provides a centralized resource for assisting investigators in meeting the complex regulatory requirements for conducting patient-oriented research. The Research Study Volunteer Project (RSVP) serves as a resource for CFAR investigators to improve the efficiency of their research efforts by creating and maintaining a database of HIV-infected and uninfected individuals in the Los Angeles area who are interested and willing to be contacted for HIV-related research studies and/or are willing to have their self-reported medical information mined for research

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028697-25
Application #
8631029
Study Section
Special Emphasis Panel (ZAI1-UKS-A)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
25
Fiscal Year
2014
Total Cost
$348,728
Indirect Cost
$68,644
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chin, Chee Jia; Li, Suwen; Corselli, Mirko et al. (2018) Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports 10:436-446
Adachi, Kristina; Xu, Jiahong; Ank, Bonnie et al. (2018) Congenital CMV and HIV Perinatal Transmission. Pediatr Infect Dis J :
Bristow, Claire C; Klausner, Jeffrey D (2018) Using Treponemal Assay Signal Strength Cutoff Ratios To Predict Syphilis Infection. J Clin Microbiol 56:
Montecino-Rodriguez, Encarnacion; Casero, David; Fice, Michael et al. (2018) Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol 200:2046-2056
Sun, Jie; He, Xin; Zhu, Yinghui et al. (2018) SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. Cell Stem Cell 23:355-369.e9
Shannon, Chelsea L; Klausner, Jeffrey D (2018) The growing epidemic of sexually transmitted infections in adolescents: a neglected population. Curr Opin Pediatr 30:137-143
Bristow, Claire C; Shannon, Chelsea; Herbst de Cortina, Sasha et al. (2018) Use of Oral Fluid With a Rapid Treponemal Test for Syphilis Evaluation. Sex Transm Dis 45:e65-e67
Withers, Keenan; Bristow, Clare; Nguyen, Minh et al. (2018) A field evaluation of a rapid dual immunoassay for human immunodeficiency virus and syphilis antibodies, Hanoi, Vietnam. Int J STD AIDS :956462418802685
Beymer, Matthew R; DeVost, Michelle A; Weiss, Robert E et al. (2018) Does HIV pre-exposure prophylaxis use lead to a higher incidence of sexually transmitted infections? A case-crossover study of men who have sex with men in Los Angeles, California. Sex Transm Infect 94:457-462
Bristow, Claire C; Kojima, Noah; Lee, Sung-Jae et al. (2018) HIV and syphilis testing preferences among men who have sex with men and among transgender women in Lima, Peru. PLoS One 13:e0206204

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