This application constitutes a renewal on the part of the University of California Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage the AIDS research activities with a bottom-up approach to governance, allowing participation by all faculty in all of our programs. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross disciplinary collaborations. The UCLA CFAR consists of more than 200 investigators who are responsible for research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative and interdisciplinary research projects. The action plan for the first year of requested support is summarized as follows: The CFAR plans to continue supporting nine of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Humanized Mouse Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, a Clinical Research Facilitation Core and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short-and long-term goals, one core was eliminated and we developed an HIV+ and HIV- subject registry through our Clinical Research Facilitation Core. Inclusion of this resource will be highly beneficial to clinical, behavioral and basic science studies.

Public Health Relevance

Research into the pathogenesis, treatment and social aspects of HIV disease is needed to end this epidemic. Our program is designed to integrate clinical, behavioral and basic sciences and to provide valuable core services to facilitate AIDS research. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities particularly hard hit by this disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028697-28
Application #
9233993
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Program Officer
Namkung, Ann S
Project Start
1997-07-01
Project End
2018-02-28
Budget Start
2017-03-01
Budget End
2018-02-28
Support Year
28
Fiscal Year
2017
Total Cost
$2,147,427
Indirect Cost
$425,384
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Daniels, Joseph; Marlin, Robert; Medline, Alex et al. (2018) Getting HIV Self-Test Kits into the Home for Young African American MSM in Los Angeles: A Qualitative Report. J Assoc Nurses AIDS Care 29:115-119
Allan-Blitz, Lao-Tzu; Herrera, M Christina; Calvo, Gino M et al. (2018) Venue-Based HIV-Testing: An Effective Screening Strategy for High-Risk Populations in Lima, Peru. AIDS Behav :
Beymer, Matthew R; Holloway, Ian W; Grov, Christian (2018) Comparing Self-Reported Demographic and Sexual Behavioral Factors Among Men Who Have Sex with Men Recruited Through Mechanical Turk, Qualtrics, and a HIV/STI Clinic-Based Sample: Implications for Researchers and Providers. Arch Sex Behav 47:133-142
Bantjes, J; Tomlinson, M; Weiss, R E et al. (2018) Non-fatal suicidal behaviour, depression and poverty among young men living in low-resource communities in South Africa. BMC Public Health 18:1195
Fehrenbacher, Anne E; Chowdhury, Debasish; Jana, Smarajit et al. (2018) Consistent Condom Use by Married and Cohabiting Female Sex Workers in India: Investigating Relational Norms with Commercial Versus Intimate Partners. AIDS Behav :
Borrell, Luisa N (2018) Editorial: Critical Race Theory: Why Should We Care about Applying It in our Research? Ethn Dis 28:215-218
Shin, S S; Modongo, C; Zetola, N M et al. (2018) High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana. Int J Tuberc Lung Dis 22:366-370
Airhihenbuwa, Collins O; Ford, Chandra L (2018) Editorial: Critical Race Theory - We Are all Others. Ethn Dis 28:219-222
Chin, Chee Jia; Li, Suwen; Corselli, Mirko et al. (2018) Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports 10:436-446
Adachi, Kristina; Xu, Jiahong; Ank, Bonnie et al. (2018) Congenital CMV and HIV Perinatal Transmission. Pediatr Infect Dis J :

Showing the most recent 10 out of 942 publications