This application requests renewal of support for the fourth funding period (years 16-20) of the Baylor- UT Houston Center for AIDS Research (CFAR). Both institutional partners are located in the vibrant Texas Medical Center in Houston, Texas. Houston is the fourth largest city in the US with a very diverse population and is ranked 7th in the US (2007) for cumulative number of AIDS cases. This current funding period (2004-2009) has proven the value of the synergistic partnership between Baylor College of Medicine and The University of Texas Health Science Center, raising CFAR efforts in HIV/AIDS research in Houston to a new level. Our historically successful Developmental grants program continued to foster HIV/AIDS research, with a lifetime record (1994-2008) of invested CFAR funds resulting in over 18-fold leveraging as reflected by new external funding to grantees. A comprehensive strategic planning process guided the CFAR in the development of visionary and proactive plans for the next 5 years that capitalize on unique strengths and opportunities. CFAR goals are supported by the expertise and services of six scientific cores: Immunology, Virology, Clinical Research, Design &Analysis, Behavioral Sciences, and International Research. New to this application, we propose to support a Scientific Program on HIV Associated Malignancies that builds upon opportunities provided by the recent development of an NCI designated Cancer Center at Baylor. Also new are identified Opportunity Areas that create a mechanism for Core Directors to provide proactive leadership in areas with potential to positively impact HIV/AIDS research at the CFAR. One opportunity to be pursued is developing ties with the Southwest National Primate Research Center in San Antonio, Texas, to facilitate CFAR member research involving nonhuman primates. Maturation of infrastructure and human capacity at international sites provides exciting possibilities for collaborative research which will be exploited in the next funding period. We will provide inter-CFAR leadership to support an innovative educational program on infectious diseases developed for middle schools. The unique environment of the Texas Medical Center creates many opportunities for scientific, clinical, and educational collaborations, of which the CFAR takes full advantage.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UT Houston supports research on the pathogenesis, prevention, detection, and treatment of HIV infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The CFAR seeks renewal of support to continue its comprehensive efforts against HIV/AIDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-18
Application #
8320270
Study Section
Special Emphasis Panel (ZAI1-JBS-A (J1))
Program Officer
Namkung, Ann S
Project Start
1997-04-01
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$1,798,269
Indirect Cost
$528,661
Name
Baylor College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Chaboub, Lesley S; Manalo, Jeanne M; Lee, Hyun Kyoung et al. (2016) Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci 36:11904-11917
Bui, Thanh Cong; Tran, Ly Thi-Hai; Hor, Leng Bun et al. (2016) Intravaginal Practices in Female Sex Workers in Cambodia: A Qualitative Study. Arch Sex Behav 45:935-43
Shore, Amy N; Chang, Chi-Hsuan; Kwon, Oh-Joon et al. (2016) PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol 409:202-17
Pethő, Zoltán; Tanner, Mark R; Tajhya, Rajeev B et al. (2016) Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther 18:103
Kwon, Oh-Joon; Zhang, Li; Xin, Li (2016) Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells 34:191-202
Gundry, Michael C; Brunetti, Lorenzo; Lin, Angelique et al. (2016) Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep 17:1453-1461
Yang, Liubin; Rodriguez, Benjamin; Mayle, Allison et al. (2016) DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 29:922-34
Arya, Monisha; Patel, Sajani; Kumar, Disha et al. (2016) Why Physicians Don't Ask: Interpersonal and Intrapersonal Barriers to HIV Testing-Making a Case for a Patient-Initiated Campaign. J Int Assoc Provid AIDS Care 15:306-12
Toneff, M J; Sreekumar, A; Tinnirello, A et al. (2016) The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol 14:47
Feng, Zizhen; Yao, Yuan; Zhou, Chao et al. (2016) Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol 9:24

Showing the most recent 10 out of 579 publications