This application requests renewal of support for the fourth funding period (years 16-20) of the Baylor- UT Houston Center for AIDS Research (CFAR). Both institutional partners are located in the vibrant Texas Medical Center in Houston, Texas. Houston is the fourth largest city in the US with a very diverse population and is ranked 7th in the US (2007) for cumulative number of AIDS cases. This current funding period (2004-2009) has proven the value of the synergistic partnership between Baylor College of Medicine and The University of Texas Health Science Center, raising CFAR efforts in HIV/AIDS research in Houston to a new level. Our historically successful Developmental grants program continued to foster HIV/AIDS research, with a lifetime record (1994-2008) of invested CFAR funds resulting in over 18-fold leveraging as reflected by new external funding to grantees. A comprehensive strategic planning process guided the CFAR in the development of visionary and proactive plans for the next 5 years that capitalize on unique strengths and opportunities. CFAR goals are supported by the expertise and services of six scientific cores: Immunology, Virology, Clinical Research, Design &Analysis, Behavioral Sciences, and International Research. New to this application, we propose to support a Scientific Program on HIV Associated Malignancies that builds upon opportunities provided by the recent development of an NCI designated Cancer Center at Baylor. Also new are identified Opportunity Areas that create a mechanism for Core Directors to provide proactive leadership in areas with potential to positively impact HIV/AIDS research at the CFAR. One opportunity to be pursued is developing ties with the Southwest National Primate Research Center in San Antonio, Texas, to facilitate CFAR member research involving nonhuman primates. Maturation of infrastructure and human capacity at international sites provides exciting possibilities for collaborative research which will be exploited in the next funding period. We will provide inter-CFAR leadership to support an innovative educational program on infectious diseases developed for middle schools. The unique environment of the Texas Medical Center creates many opportunities for scientific, clinical, and educational collaborations, of which the CFAR takes full advantage.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UT Houston supports research on the pathogenesis, prevention, detection, and treatment of HIV infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The CFAR seeks renewal of support to continue its comprehensive efforts against HIV/AIDS.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-JBS-A (J1))
Program Officer
Namkung, Ann S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Schools of Medicine
United States
Zip Code
Lam, Sharon; Sung, Julia; Cruz, Conrad et al. (2015) Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther 23:387-95
Gordon, Alasdair J E; Satory, Dominik; Wang, Mengyu et al. (2014) Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity. Nucleic Acids Res 42:12015-26
Cerne, Jasmina Ziva; Hartig, Sean Michael; Hamilton, Mark Patrick et al. (2014) Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci 55:2130-9
Blackmore, Julia K; Karmakar, Sudipan; Gu, Guowei et al. (2014) The SMRT coregulator enhances growth of estrogen receptor-?-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis. Endocrinology 155:3251-61
Singh, Ravi K; Xia, Zheng; Bland, Christopher S et al. (2014) Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. Mol Cell 55:592-603
Fongkaew, Warunee; Viseskul, Nongkran; Suksatit, Benjamas et al. (2014) Verifying quantitative stigma and medication adherence scales using qualitative methods among Thai youth living with HIV/AIDS. J Int Assoc Provid AIDS Care 13:69-77
Nguyen, Dan; Hsu, Jean W; Jahoor, Farook et al. (2014) Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab 99:169-77
Chen, Jiyuan; Xia, Yunfeng; Lin, Xia et al. (2014) Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis. Lab Invest 94:545-56
Ross, Michael W; Nyoni, Joyce; Ahaneku, Hycienth O et al. (2014) High HIV seroprevalence, rectal STIs and risky sexual behaviour in men who have sex with men in Dar es Salaam and Tanga, Tanzania. BMJ Open 4:e006175
Santiago, Felix W; Covaleda, Lina M; Sanchez-Aparicio, Maria T et al. (2014) Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses. J Virol 88:4572-85

Showing the most recent 10 out of 248 publications