The Baylor-UTHouston CFAR Immunology Core is designed to provide state-of-the-art flow cytometric capabilities, expertise for non-flow cytometry immunological assays, and technical training desired by members of the CFAR. A major goal Is to support research of high-priority CFAR initiatives that foster interdisciplinary research in areas of opportunity. The Core is organized into two separate but complementary laboratories, the Cytometry Laboratory (located at Baylor College of Medicine) and the Clinical Immunology Laboratory (located at UTHouston Medical School). Routine flow cytometry and cell sorting is conducted at reduced cost to CFAR members at the Cytometry Laboratory. The Clinical Immunology Laboratory provides other immunology services, including development and characterization of new assays such as ELISA and ELISPOT assays to measure biomarkers. The highly successful Immunology Core is directed by Dr. Dorothy E. Lewis, who has over 30 years of flow and immunologic experience and an outstanding track-record of bringing together interdisciplinary investigators. The CFAR Cytometry Laboratory at Baylor is managed by Joel Sederstrom, and the CFAR Clinical Immunology Laboratory at UTHouston by Jacob Couturier. The Core is supervised by an Oversight Committee. Future opportunity areas to be pursued by the Core include development of BSL2+ cell sorting capability, development of immune assays, and provision of advanced training in immunological methods. The Core Director has responsibility for day-to-day running of the Core laboratories;priorities for usage are prescribed in a standardized manner;a charge-back system is implemented where appropriate. This Core has been highly utilized and appreciated in our previous funding periods and it is anticipated that investigators at Baylor and UTHouston will benefit from its expanded services. Its support is essential for the continued success of the Baylor-UTHouston CFAR.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UTHouston supports research on the pathogenesis, prevention, detection, and treatment of HIV infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The Immunology Core provides expertise on studies of the immune system in HIV-infected patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-18
Application #
8382335
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$130,902
Indirect Cost
$36,079
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Temereanca, Aura; Oprea, Cristiana; Wertheim, Joel O et al. (2017) HIV transmission clusters among injecting drug users in Romania. Romanian biotechnological letters 22:12307-12315
Kadmon, Claudine S; Landers, Cameron T; Li, Haiyan S et al. (2017) MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol 56:7-15
Yeh, Szu-Ying; Huang, Wei-Hsiang; Wang, Wei et al. (2017) Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron 94:294-303.e4
Lietman, Caressa D; Lim, Joohyun; Grafe, Ingo et al. (2017) Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone. J Bone Miner Res 32:1354-1367
Vernetti, Lawrence; Gough, Albert; Baetz, Nicholas et al. (2017) Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep 7:42296
He, Huan; Xue, Jing; Wang, Weiming et al. (2017) Efficient Transduction of Human and Rhesus Macaque Primary T Cells by a Modified Human Immunodeficiency Virus Type 1-Based Lentiviral Vector. Hum Gene Ther 28:271-285
Yang, Lina; Liu, Li; Gao, Hong et al. (2017) The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis. J Hematol Oncol 10:159
Lo, Yuan-Hung; Chung, Eunah; Li, Zhaohui et al. (2017) Transcriptional Regulation by ATOH1 and its Target SPDEF inĀ theĀ Intestine. Cell Mol Gastroenterol Hepatol 3:51-71
Kaiser, Philipp; Joshi, Sunil K; Kim, Peggy et al. (2017) Assays for precise quantification of total (including short) and elongated HIV-1 transcripts. J Virol Methods 242:1-8
Huo, Yanling; Patel, Kunjal; Scott, Gwendolyn B et al. (2017) Lymphocyte subsets in HIV-exposed uninfected infants and HIV-unexposed uninfected infants. J Allergy Clin Immunol 140:605-608.e3

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