The Baylor-UTHouston CFAR Clinical Research Core has maintained a proactive approach to facilitating interdisciplinary HIV/AIDS translational research that has produced over 70 peer-reviewed publications of Baylor-UTHouston CFAR investigators as well as numerous abstract presentations and publications. The Co-Directors are Dr. William T. Shearer (Pediatric Component) and Dr. Roberto C. Arduino (Adult Component). The goals of the Core are to: (1) Provide integrated access to pediatric and adult patient HIV-infected populations and clinical materials;(2) Facilitate novel research, targeted research projects, and scientific programs in critical areas of HIV/AIDS research;(3) Establish community outreach and educational programs to expand CFAR research opportunities;and (4) Assist investigators with interpretation of HIV study data. The sources of well-characterized patient populations and clinical materials are the Pediatric HIV Research Center at Texas Children's Hospital and the Houston AIDS Research Team site at Thomas Street Health Center (Baylor and UTHouston) where adult patients are seen. More than 100 children and 3000 adults are followed;NIH-funded HIV research programs support clinical studies on these patients (IMPAACT, PHACS, INSIGHT and ACTG). The Veterans Affairs Medical Center is another source of HIV-infected adults (over 700 patients). Core services include providing information on patient populations and assisting with procurement of specimens. A Core Oversight Committee reviews and prioritizes requests (concept sheets) for access to patients or specimens. The Core collects, processes, and stores patient research materials for approved studies. The Core will assist investigators in gaining access to the PHACS national database and its centralized specimen repository. Locally, specimens from selected adult patients are banked for research studies. The Core provides crucial support to new efforts to target translational research into areas that are gaps at our CFAR and that encourage interactions among CFAR cores and CFAR members at Baylor and UTHouston. Several recent examples are described in which the Core fostered innovative collaborative studies. The Core works with community groups, sponsors clinical conferences, and disseminates information to promote CFAR research opportunities. Outcomes measures will be used to assess the success of the Core each year.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UTHouston supports research on the pathogenesis, prevention, detection, and treatment of HIV Infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The Clinical Research Core provides expertise on clinical trials and access to patient samples.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-JBS-A)
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Lam, Sharon; Sung, Julia; Cruz, Conrad et al. (2015) Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther 23:387-95
Gordon, Alasdair J E; Satory, Dominik; Wang, Mengyu et al. (2014) Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity. Nucleic Acids Res 42:12015-26
Cerne, Jasmina Ziva; Hartig, Sean Michael; Hamilton, Mark Patrick et al. (2014) Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci 55:2130-9
Blackmore, Julia K; Karmakar, Sudipan; Gu, Guowei et al. (2014) The SMRT coregulator enhances growth of estrogen receptor-?-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis. Endocrinology 155:3251-61
Singh, Ravi K; Xia, Zheng; Bland, Christopher S et al. (2014) Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis. Mol Cell 55:592-603
Fongkaew, Warunee; Viseskul, Nongkran; Suksatit, Benjamas et al. (2014) Verifying quantitative stigma and medication adherence scales using qualitative methods among Thai youth living with HIV/AIDS. J Int Assoc Provid AIDS Care 13:69-77
Nguyen, Dan; Hsu, Jean W; Jahoor, Farook et al. (2014) Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab 99:169-77
Chen, Jiyuan; Xia, Yunfeng; Lin, Xia et al. (2014) Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis. Lab Invest 94:545-56
Ross, Michael W; Nyoni, Joyce; Ahaneku, Hycienth O et al. (2014) High HIV seroprevalence, rectal STIs and risky sexual behaviour in men who have sex with men in Dar es Salaam and Tanga, Tanzania. BMJ Open 4:e006175
Santiago, Felix W; Covaleda, Lina M; Sanchez-Aparicio, Maria T et al. (2014) Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses. J Virol 88:4572-85

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