The purpose of the International Research Core is to promote and facilitate translational HIV/AIDS research by Baylor-UTHouston CFAR members in international settings. Over the past 10 years, the Baylor International Pediatric AIDS Initiative (BIPAI), supported in part by the International Research Core, has grown from a small, laboratory-based program focused in Romania to encompass the world's largest network of pediatric and family HIV treatment and research centers with over 30,000 HIV-infected patients in care. These centers are linked with one another, and together they serve as a resource capable of facilitating collaborative HIV/AIDS research across nine distinct international settings in Romania, Botswana, Lesotho, Malawi, Swaziland, Uganda, Tanzania, Burkina Faso, and Kenya. The International Research Core has been extraordinarily efficient and productive to date. The partnership with the Stefan Nicolau Institute of Virology in Bucharest has been a particular source of pride;our support for this relationship is reflected in our request for continued allocation of a substantial proportion of CFAR International Research Core funds to this partner. The CFAR International Research Core has contributed greatly to the success of the NIH-funded AIDS International Research and Training Program scholars. Other projects (such as the BANA 2 trial in Gaborone, Botswana) have been catalyzed by CFAR input and contributions. The CFAR International Research Core is now poised for exponential growth, as nearly limitless opportunities for epidemiological, operational, and clinical research can be realized through the newly implemented electronic medical records system. This electronic medical records system currently includes data on 30,000 patients in seven sites. This new tool has the potential to galvanize both retrospective and prospective research among existing core users and will attract additional new users to the core.

Public Health Relevance

The Center for AIDS Research (CFAR) at Baylor-UTHouston supports research on the pathogenesis, prevention, detection, and treatment of HIV infection and AIDS. The CFAR has been an essential catalyst for HIV/AIDS research in the Houston area. The State of Texas ranks fourth in the total number of AIDS cases in the United States. The International Research Core provides infrastructure and capacity for international research at a network of sites in Africa and Romania.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036211-19
Application #
8513237
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
19
Fiscal Year
2013
Total Cost
$190,137
Indirect Cost
$54,405
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Martini-Stoica, Heidi; Cole, Allysa L; Swartzlander, Daniel B et al. (2018) TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med 215:2355-2377
Kogiso, Mari; Qi, Lin; Braun, Frank K et al. (2018) Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models. Clin Cancer Res 24:2159-2170
Xiao, Yangyan; de Paiva, Cintia S; Yu, Zhiyuan et al. (2018) Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol 30:457-470
Yosef, Nejla; Vadakkan, Tegy J; Park, June-Hee et al. (2018) The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages. Dev Biol 442:138-154
Kho, Jordan; Tian, Xiaoyu; Wong, Wing-Tak et al. (2018) Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet 103:276-287
Grzeskowiak, Caitlin L; Kundu, Samrat T; Mo, Xiulei et al. (2018) In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nat Commun 9:2732
Zaheer, Mahira; Wang, Changjun; Bian, Fang et al. (2018) Protective role of commensal bacteria in Sjögren Syndrome. J Autoimmun 93:45-56
Lu, Lianghao; Wen, Yefei; Yao, Yuan et al. (2018) Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics 8:2189-2201
Xiong, Wei; Chen, Yuhui; Kang, Xi et al. (2018) Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells. Mol Ther 26:963-975
Zou, Winnie Y; Blutt, Sarah E; Zeng, Xi-Lei et al. (2018) Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep 22:1003-1015

Showing the most recent 10 out of 690 publications