UCSD has made a strong commitment to AIDS research, as reflected by the high caliber of its faculty conducting both basic and clinical research related to HIV, and by recent plans to establish and AIDS Research Institute as an Organized Research Unit (ORU). The goals of a CFAR at UCSD are in accord with the goals envisioned for the AIDS Research Institute, which are to provide mechanisms to generate improved core research facilities, to foster interactions among researchers, to provide support for new investigators and feasibility studies, and to provide educational and training opportunities in the many areas related to HIV infection. Dr. Wong-Staal will serve as P.I. and Director of the UCSD CFAR. She will be assisted by Dr. Douglas Richman, Deputy Director, in overseeing the performance of the CFAR. Dr. Wong-Staal and Dr. Richman have complementary areas of expertise, and their cooperation should strengthen he interaction of basic and clinical AIDS researcher at UCSD. There will be three basic science cores: Molecular and two clinical cores: Primary Virus Isolation and Specimen Banking Core Data and Analysis Core. The thematic area of this CFAR application is 'Molecular Approaches to AIDS Therapy and Prevention'. Current AIDS-related activities at UCSD span basic studies on viral regulation, mechanisms of pathogenesis, preclinical development of therapy and vaccine strategies and clinical studies that impact on opportunistic infections, neurobiology and psychiatry and clinical treatment of AIDS. In addition to R01 support to individual investigators, there are coordinated efforts that include the AIDS Clinical Trial Units (ACTU) for adult and pediatric patients, a National Co-operative Vaccine Discovery Group and the NIH Postdoctoral AIDS Research Training Grant. The multidisciplinary research goals of the CFAR are several fold: to conduct basic research in the areas of molecular pathogenesis and immunopathogenesis of AIDS; to utilize insight from the basic studies to develop preclinical studies on therapy and prevention; to design Phase I/II clinical trials based on promising preclinical data; and to modify existing treatment regimens based on basic research and preclinical data. Accomplishment of these goals will be greatly facilitated from the proposed CFAR research support and developmental cores.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (SRC (70))
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
Zip Code
Morales, Mario; Rafful, Claudia; Gaines, Tommi L et al. (2018) Factors associated with extrajudicial arrest for syringe possession: results of a department-wide survey of municipal police in Tijuana, Mexico. BMC Int Health Hum Rights 18:36
Rhodes, Tim (2018) The becoming of methadone in Kenya: How an intervention's implementation constitutes recovery potential. Soc Sci Med 201:71-79
Christensen-Quick, Aaron; Chaillon, Antoine; Yek, Christina et al. (2018) Influenza Vaccination Can Broadly Activate the HIV Reservoir During Antiretroviral Therapy. J Acquir Immune Defic Syndr 79:e104-e107
Ben Hamida, Amen; Rafful, Claudia; Jain, Sonia et al. (2018) Non-injection Drug Use and Injection Initiation Assistance among People Who Inject Drugs in Tijuana, Mexico. J Urban Health 95:83-90
Groessl, Erik J; Ganiats, Theodore G; Hillery, Naomi et al. (2018) Cost analysis of rapid diagnostics for drug-resistant tuberculosis. BMC Infect Dis 18:102
Dillon, Stephanie M; Guo, Kejun; Austin, Gregory L et al. (2018) A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis. AIDS 32:1599-1611
Goldenberg, Shira M; Rocha Jiménez, Teresita; Brouwer, Kimberly C et al. (2018) Influence of indoor work environments on health, safety, and human rights among migrant sex workers at the Guatemala-Mexico Border: a call for occupational health and safety interventions. BMC Int Health Hum Rights 18:9
Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2018) Impact of Public Safety Policies on Human Immunodeficiency Virus Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis 66:758-764
Dinesha, T R; Boobalan, J; Sivamalar, S et al. (2018) Occult HBV infection in HIV-infected adults and evaluation of pooled NAT for HBV. J Viral Hepat 25:718-723
Fraser, Hannah; Zibbell, Jon; Hoerger, Thomas et al. (2018) Scaling-up HCV prevention and treatment interventions in rural United States-model projections for tackling an increasing epidemic. Addiction 113:173-182

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