Overview - The UCSD Center for AIDS Research (CFAR) engages, synergizes and serves investigators at UCSD (including the Veterans Medical Research Foundation of the San Diego VA Healthcare System), The Scripps Research Institute, the Salk Institute, and the La Jolla Institute for Allergy and Immunology. Since 1994, the CFAR has enhanced HIV/AIDS activities at the participating institutions and the San Diego community by 1) encouraging young faculty and investigators new to HIV/AIDS research through Developmental Grant Awards;2) providing expert advice and services in a number of specialized research areas through the CFAR Cores, and 3) fostering research interactions and community wide education through mentoring, training. Scientific Focus Groups, education, and outreach programs.
The specific aims of the UCSD CFAR are to a) provide development and implementation of innovative HIV research and the foundation and framework for highly productive collaborations across disciplines, investigators, and our four member institutions, b) provide training, inspiration, mentoring, and expert guidance (TIME) to trainees and junior and international investigators, c) create scientific cores that extend the scientific reach of CFAR investigators, d) capitalize on our international expertise, proximity to Mexico and MEPI programs to create locally sustainable HIV research programs in targeted resource limited settings, e) foster collaborations across CFARs for NIH-funded programs and initiatives, and f) develop a strategic plan for the growth of the CFAR and to flexibly adapt to a constantly evolving research environment. Since our renewal in 2007, these efforts are yielding a productive, enthusiastic and growing group of investigators. As the synergy between our investigators and member institutions increases, we have identified the need to expand our infrastructure to address new and expanding opportunities. We have added new faculty members and expanded scientific interactions with local institutions. The revised and improved CFAR is comprised of nine Cores: Administrative, Developmental, Flow Cytometry, Genomics and Sequencing, Clinical Investigation and Biostatistics, Protein Expression and Proteomics, International, Translational Virology, and Bioinformatics and Information Technologies. We continue to be guided by our External Advisory and Executive Committees, as well as the CFAR Director and Co-Directors, Core Directors, Scientific Focus Groups and our membership.

Public Health Relevance

The UCSD CFAR supports basic, clinical and translational research programs at UCSD and at our member institutions. In addition to our active, productive and groundbreaking research, we have a remarkable program for fostering the development of junior faculty and investigators new to HIV research.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-UKS-A (J1))
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Namkung, Ann S
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University of California San Diego
Schools of Medicine
La Jolla
United States
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Heaton, Robert K; Franklin Jr, Donald R; Deutsch, Reena et al. (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473-80
Hepler, N Lance; Scheffler, Konrad; Weaver, Steven et al. (2014) IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform. PLoS Comput Biol 10:e1003842
Szumowski, Suzannah C; Botts, Michael R; Popovich, John J et al. (2014) The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans. Proc Natl Acad Sci U S A 111:8215-20
Murrell, Ben; Murrell, Daniel; Murrell, Hugh (2014) R2-equitability is satisfiable. Proc Natl Acad Sci U S A 111:E2160
Grant, Igor; Franklin Jr, Donald R; Deutsch, Reena et al. (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055-62
Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten et al. (2014) Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers. Immunity 40:669-80
Cachay, Edward R (2014) The forgotten component in the staging and management of HIV/hepatitis C virus-coinfected patients. Clin Infect Dis 59:320-1
Jeong, Su Jin; Kim, Min Hyung; Song, Je Eun et al. (2014) Short communication: prospective comparison of qualitative versus quantitative polymerase chain reaction for monitoring virologic treatment failure in HIV-infected patients. AIDS Res Hum Retroviruses 30:827-9
Wang, Cathy X; Sather, Blythe D; Wang, Xuefeng et al. (2014) Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Blood 124:913-23
Scheffler, Konrad; Murrell, Ben; Kosakovsky Pond, Sergei L (2014) On the validity of evolutionary models with site-specific parameters. PLoS One 9:e94534

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