Core E - The principal objective of the Genomics and Sequencing (GS) Core of the Center for AIDS research (CFAR) at the University of California San Diego (UCSD) is to facilitate the research of HIV/AIDS investigators by providing cost-effective access to cutting-edge genomics and sequencing technologies. The GS Core will help investigators realize the enormous potential of these approaches to assist basic and applied research into the role of host and viral genes in HIV infection and pathogenesis, leading to new insights and treatments. Support for developmental projects and investigators new to HIV research is an area of special emphasis.
The specific aims of the GS Core are: (1) to develop and provide molecular tools and resources to HIV researchers for the determination of host and viral mechanisms of pathogenesis, (2) to guide HIV researchers in the value, use, and interpretation of genetic information and gene expression data, and (3) to facilitate education and training in genomics and sequencing technologies for CFAR investigators, students, staff, and other researchers. The GS Core will achieve these aims by providing: (1) assays for gene expression, viral detection and quantitation for research purposes, genetic variation, tools for functional genomics (e.g., siRNA expressing vectors), sequencing and/or deep sequencing of virus, host, transcriptome, or small RNAs, and provision of useful reagents to researchers, (2) analysis of gene expression and genetic variation, help with open source and proprietary tools for alignment and comparison of sequences, and collaboration with the Bioinformatics and Information Technologies (BIT) Core in molecular phylogeny studies, application-specific high throughput sequencing (HTS) pipelines, or more advanced data analysis, and (3) seminars, workshops, and individual training for graduate students and fellows, web resources, and mentoring of undergraduate independent study students. The GS Core will serve as an important resource for basic and translational HIV-related research, as best exemplified by 129 publications and 211 investigators supported by the combined services of the Genomics and Molecular Biology Cores since the last renewal. All evidence indicates the GS Core will be a valuable, productive, and popular basic science core for the UCSD CFAR.

Public Health Relevance

The Genomics and Sequencing (GS) Core of the Center for AIDS Research at UCSD provides HIV/AIDS researchers with access to the latest genomics technologies and sequencing applications for their research. The services performed by the GS Core provide information on the host and viral mechanisms of HIV associated disease. This in turn will lead to new treatments and interventions for HIV-infected individuals

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI036214-19A1
Application #
8520776
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
1994-04-01
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
19
Fiscal Year
2013
Total Cost
$470,621
Indirect Cost
$69,145
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Choi, Jun Yong; Chaillon, Antoine; Oh, Jin Ok et al. (2016) HIV migration between blood plasma and cellular subsets before and after HIV therapy. J Med Virol 88:606-13
Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5
Seifert, Marva; Georghiou, Sophia B; Catanzaro, Donald et al. (2016) MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis. J Clin Microbiol 54:912-8
Gianella, Sara; Kosakovsky Pond, Sergei L; Oliveira, Michelli F et al. (2016) Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol 2:vew020
Hoenigl, Martin; Chaillon, Antoine; Moore, David J et al. (2016) Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men. J Acquir Immune Defic Syndr 71:551-7
Karris, Maile Y; Umlauf, Anya; Vaida, Florin et al. (2016) A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore) 95:e5315
Smith, Laramie R; Patterson, Thomas L; Magis-Rodriguez, Carlos et al. (2016) Engagement in the HIV Care Continuum among Key Populations in Tijuana, Mexico. AIDS Behav 20:1017-25
Cáceres, Carlos F; Borquez, Annick; Klausner, Jeffrey D et al. (2016) Implementation of pre-exposure prophylaxis for human immunodeficiency virus infection: progress and emerging issues in research and policy. J Int AIDS Soc 19:21108
Freeman, Michael L; Lederman, Michael M; Gianella, Sara (2016) Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13:10-9
Toth, Mate; Flandreau, Elizabeth I; Deslauriers, Jessica et al. (2016) Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology 41:1681-90

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