Core G - The Clinical Investigation and Biostatistics (CB) Core supports and enables studies of the pathogenesis, treatment, and prevention of HIV disease and its complications. The Core functions as a central access point for basic, clinical, and translational investigators by providing expertise in clinical study design, study implementation, patient recruitment, clinical evaluations for research, and specimen and data collection. Importantly, the Core provides biostatistical consultation for study design, grant preparation, power considerations and statistical analysis of study results as well as assistance with manuscript preparation. The CFAR web portal allows users to submit requests to the CB Core in a uniform, easy-to-use, and readily available format that ensures rapid response to requested services. A key innovation of the CB Core is the availability of prospectively collected, high quality, real-time clinical data, from the 3000 patients in current clinical care at the Owen Clinic, which is linked to a specimen repository and patient-based outcome measures (i.e., quality of life, adherence). The data and specimens allow for identification of and access to subjects and specimens that meet specific criteria for interventional, epidemiologic, behavioral, or basic science projects. The Core interacts with other CFAR cores to enable research requiring laboratory and clinical expertise, fosters multidisciplinary research among basic, clinical, and behavioral scientists, and teaches and mentors junior investigators in the principles of clinical investigation. CFAR funding permits the CB Core to offer its services to new and junior investigators without charge in most cases. Quality-assured data sets, with key data elements that have been reviewed for consistent definitions and accuracy, are provided free to the CFAR academic community. The resources from the CB Core have been further expanded and leveraged by collaboration with seven additional CFARs across the country to form the CFAR Network of Integrated Clinical Systems (CNICS).
The specific aims of the CB Core are: to support clinical investigation and translational research;to encourage, mentor and train the next generation of HIV clinical investigators;and to provide education about and access to HIV-related research opportunities and CFAR research findings to all HIV-infected individuals, including women and underrepresented minorities in the CFAR community.

Public Health Relevance

The Clinical Investigation and Biostatistics (CB) Core promotes and enables research aimed at important questions concerning the pathogenesis, treatment, and prevention of HIV disease and its complications. The Core functions as a central access point for basic, clinical and translational investigators by providing key resources including expertise in study design and implementation, statistical analysis, patient recruitment, research clinical evaluation and specimen and data collection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI036214-19A1
Application #
8520777
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
1994-04-01
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
19
Fiscal Year
2013
Total Cost
$192,409
Indirect Cost
$30,557
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5
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Freeman, Michael L; Lederman, Michael M; Gianella, Sara (2016) Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13:10-9
Toth, Mate; Flandreau, Elizabeth I; Deslauriers, Jessica et al. (2016) Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology 41:1681-90

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