Core K - Current HIV research often requires reliable links between clinical and basic science investigators. These links include characterization and access to clinical specimens, laboratory based assays designed for clinical specimens, interpretation and management of generated data, and training in these areas. The Translational Virology (TV) Core of the UCSD CFAR is designed to be this reliable and cost-effective link. The TV Core accomplishes this goal for a wide range of HIV research-related activities involving: junior and senior investigators, established and burgeoning programs, clinical and basic science investigators, domestic and International efforts, NIH and other funders, etc. Over the past 4 years, the TV Core has provided services to 67 Investigators, contributed to 56 publications, helped 11 investigators obtain new or competing research awards and trained 48 individuals in safe laboratory procedures for working with HIV and PCR methodologies. Specifically, the TV Core provides services through four defined units that work closely with other CFAR Cores, as outlined: (1) Specimen Unit: obtains, processes, tracks, ships and cryostores samples, (primary collaborating Core: Clinical Investigation and Biostatistics) (2) Assay Unit: develops and provides a wide-range of clinically-relevant assays (HIV genotyping, viral loads, antibody and nucleic acid detection, etc.). (primary collaborating Core: Genomics and Sequencing) (3) Quality Control Unit: provides quality control procedures for domestic and International CFAR-affiliated investigators, and analytical support for generated data, (primary collaborating Core: Bioinformatics and Information Technologies) (4) Training Unit: provides training and certification in BL2 and BL3 safety and procedures, specimen processing, PCR, genotyping techniques, and laboratory quality assurance, (primary collaborating Cores: Developmental and International

Public Health Relevance

The Translational Virology (TV) Core provides essential Infrastructure and services to support new and ongoing HIV research through the UCSD CFAR. Specifically, the TV Core provides research support in clinical specimen management, relevant assays, analysis and quality assurance of assay data, and lab training. These services support the HIV research needed to better the lives of people living with HIV and for the public health as a whole.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1-UKS-A (J1))
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University of California San Diego
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Choi, Jun Yong; Chaillon, Antoine; Oh, Jin Ok et al. (2016) HIV migration between blood plasma and cellular subsets before and after HIV therapy. J Med Virol 88:606-13
Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5
Seifert, Marva; Georghiou, Sophia B; Catanzaro, Donald et al. (2016) MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis. J Clin Microbiol 54:912-8
Gianella, Sara; Kosakovsky Pond, Sergei L; Oliveira, Michelli F et al. (2016) Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol 2:vew020
Hoenigl, Martin; Chaillon, Antoine; Moore, David J et al. (2016) Clear Links Between Starting Methamphetamine and Increasing Sexual Risk Behavior: A Cohort Study Among Men Who Have Sex With Men. J Acquir Immune Defic Syndr 71:551-7
Karris, Maile Y; Umlauf, Anya; Vaida, Florin et al. (2016) A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore) 95:e5315
Smith, Laramie R; Patterson, Thomas L; Magis-Rodriguez, Carlos et al. (2016) Engagement in the HIV Care Continuum among Key Populations in Tijuana, Mexico. AIDS Behav 20:1017-25
Cáceres, Carlos F; Borquez, Annick; Klausner, Jeffrey D et al. (2016) Implementation of pre-exposure prophylaxis for human immunodeficiency virus infection: progress and emerging issues in research and policy. J Int AIDS Soc 19:21108
Freeman, Michael L; Lederman, Michael M; Gianella, Sara (2016) Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection. Curr HIV/AIDS Rep 13:10-9
Toth, Mate; Flandreau, Elizabeth I; Deslauriers, Jessica et al. (2016) Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology 41:1681-90

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